Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (10) GO Terms (14) Nucleotides (379) Proteins (30) Interactants (133) Wiki
XB-GENEPAGE-487619
Gene Symbol:
mcl1

Gene Name:
MCL1, BCL2 family apoptosis regulator

Synonyms:
mcl-1 , mcl1l , mcl1s , bcl2l3 ( Add synonyms , Nomenclature history )

Gene Function:
apoptosis regulator

Protein Function :



Interactants:
Loading ...

Diseases: 


External Links:
1/2
 
Xenbase Gene ID XB-GENE-487620 XB-GENE-6008975 XB-GENE-17344737
Gene Symbol mcl1 mcl1.L mcl1.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100038211
100192362
108700339
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein Uniprot NCBI Protein RefSeq  More.. NCBI Protein TrEMBL
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mcl1 mcl1.L mcl1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards MCL1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mcl1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mcl1 Ensembl
zebrafish
chicken
GEISHA MCL1 Ensembl
fruit fly
Publications
First Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak., J Cell Biol 2007                
Most Recent Mcl1 protein levels and Caspase-7 executioner protease control axial organizer cells survival., Dev Dyn 2020                
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 7 terms 7 terms
PANTHER mcl1
KEGG Pathways K02539 K02539 K02539
KOG [T] Anti-apoptotic Bcl-2 family proteins, prevent opening of mitochondrial porin channel
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mcl1
Clones Horizon Source BioScience Horizon Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info