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Summary Expression Gene Literature (2434) GO Terms (12) Nucleotides (111) Proteins (42) Interactants (1633) Wiki
XB-GENEPAGE-487723
Gene Symbol:
nog

Gene Name:
noggin

Synonyms:
nog-A , noggin 1 , noggin , nog1 , noggin-1 , Noggin1 ( Add synonyms , Nomenclature history )

Gene Function:
extracellular BMP antagonist

Protein Function :
Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface recepto...[+]


InterPro :
NADP OxRdtase dom sf , Aldo/keto reductase , Aldo/ket reductase CS , NADP OxRdtase dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
proximal symphalangism [+]

OMIM:
SYMPHALANGISM, PROXIMAL, 1A; SYM1A [+]

External Links:
GEO Series :
GSE64551, GSE83784.
1/7
 
Xenbase Gene ID XB-GENE-487724 XB-GENE-864891 XB-GENE-17332089
Gene Symbol nog nog.L nog.S
Chromosome Chr10 chr9_10L Scaffold27
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493191
373646
108704141
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nog nog.L nog.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards NOG OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Nog MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Nog Ensembl
zebrafish
ZFIN, AGR nog1 ZFIN Ensembl
chicken
GEISHA NOG Ensembl
fruit fly
worm
Publications
First Dissecting Wnt signalling pathways and Wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis., Dev Suppl 1992  
Most Recent Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins., Gene Expr Patterns 2020                          
All View All Papers 84 paper(s) referencing morpholinos 13 paper(s) referencing OMIMs 12 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 6 terms 0 term
PANTHER nog
KEGG Pathways K04658 K04658
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nog
Antibodies Nog Ab1 Nog Ab1
Morpholinos nog MO1 , nog MO2 nog MO1 , nog MO2 nog MO1 , nog MO2
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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