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Summary Expression Gene Literature (446) GO Terms (10) Nucleotides (94) Proteins (28) Interactants (958) Wiki
XB-GENEPAGE- 487723

Gene Symbol: nog

Gene Name: noggin

Synonyms: nog-A , noggin 1 , noggin , nog1 , noggin-1 , Noggin1
Add Xenopus synonyms , Nomenclature history


Gene Function: extracellular BMP antagonist

Protein Function:
Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors. Capable of inducing dorsal development in embryos. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA. None of these molecules causes dorsal mesoderm formation when expressed alone.

Interactants: bmp4 (162) , chrd.1 (155) , t (126) , otx2 (107) , gsc (100) , ncam1 (98) , actl6a (96) View All

OMIM Disease Associations: SYMPHALANGISM, PROXIMAL, 1A; SYM1A [+]
1/7
 
Xenbase Gene ID XB-GENE-487724 XB-GENE-864891 XB-GENE-17332089
Genome X. tropicalis X. laevis L X. laevis S
Gene Symbol nog nog.L nog.S
Chromosome Chr10 chr9_10L Scaffold27
Molecules tropicalis laevis .L laevis.S
Gene GBrowse 8.0 GBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 GBrowse 7.2 GBrowse 6.0 GBrowse 9.1
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis .L laevis.S
Genome Browser
GBrowse
tropicalis genome v8.0 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis .L laevis.S
Ensembl Ensembl
UniGene Str.29004 Xl.834
RNA-seq profile: Owens, Blitz et al. 2016 nog
Images 32 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis .L laevis.S
XenMine nog nog.L nog.S
Phenotype tropicalis laevis .L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NOG OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Nog MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN nog1 ZFIN Ensembl
chicken
GEISHA NOG Ensembl
fruit fly
worm
WORMBASE
Publications
First: Dissecting Wnt signalling pathways and Wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis. [Dev Suppl 1992]
Most recent: Tbx2 regulates anterior neural specification by repressing FGF signaling pathway. [Dev Biol 2017]
View All Papers 82 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis .L laevis.S
GO 7 terms 7 terms 0 term
EC
PANTHER nog
KEGG K04658 K04658
KOG
Reagents tropicalis laevis .L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones   EXRC - 2 clone(s)  
GE Dharmacon GE Dharmacon GE Dharmacon
geneservice/RZPD imagenes geneservice/RZPD imagenes
Antibody Nog Ab1 Nog Ab1
Morpholino nog MO1 nog MO1 nog MO1
Affymetrix 1.0 Str.29004.1.S1_at Xl.834.1.S1_at
Affymetrix 2.0 Xl2.834.1.A1_at

Symbol legend[+]

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