Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (14) GO Terms (3) Nucleotides (38) Proteins (21) Interactants (174) Wiki
XB-GENEPAGE-487754
Gene Symbol:
casp8

Gene Name:
caspase 8

Synonyms:
xCaspase-8 , caspase-8 , xcaspase 8 , caspase 8 ( Add synonyms , Nomenclature history )

Gene Function:
apoptotic cysteine protease

Protein Function :


InterPro :
FLASH , Villin/Gelsolin , Villin headpiece , ADF-H/Gelsolin-like dom sf [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
autoimmune lymphoproliferative syndrome type 2B [+]

OMIM:
HEPATOCELLULAR CARCINOMA [+]

External Links:
 
Xenbase Gene ID XB-GENE-487755 XB-GENE-865733 XB-GENE-17342609
Gene Symbol casp8 casp8.L casp8.S
Chromosome Chr9 chr9_10L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100495471
373559
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine casp8 casp8.L casp8.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards CASP8 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Casp8 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Casp8 Ensembl
zebrafish
ZFIN, AGR casp8 ZFIN Ensembl
chicken
GEISHA CASP8 Ensembl
fruit fly
Publications
First Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c., J Biol Chem 1998  
Most Recent Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage., Biochim Biophys Acta 2016                                  
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 0 term 3 terms 0 term
PANTHER casp8
KEGG Pathways K04398
KOG [D] Caspase, apoptotic cysteine protease
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks casp8
Clones Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info