Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (29) GO Terms (2) Nucleotides (162) Proteins (21) Interactants (387) Wiki
XB-GENEPAGE-487774
Gene Symbol:
frat1

Gene Name:
frequently rearranged in advanced T-cell lymphomas 1

Synonyms:
gbp , gsk binding protein ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
Binds GSK-3 and prevents GSK-3-dependent phosphorylation. Regulates the stability of beta-catenin in embryos. Maternal GBP is required for dorsal-ventral axis formation.


InterPro :
GSK3-bd

Interactants:
Loading ...

Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-487775 XB-GENE-17342041 XB-GENE-865735
Gene Symbol frat1 frat1.L frat1.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 100491326
398043
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine frat1 frat1.L frat1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FRAT1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Frat1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Frat1 Ensembl
zebrafish
chicken
fruit fly
worm
Publications
First GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis., Cell 1998  
Most Recent Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation., Nat Commun 2020              
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 0 term 0 term 2 terms
PANTHER frat1
KEGG Pathways K03096 K03096
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks frat1
ORFs frat1.S ORF1
Clones Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info