Gene Symbol: cdkn1a Gene Name: cyclin-dependent kinase inhibitor 1A (p21, Cip1) Synonyms: p16Xic2, p21, cip1 Add Xenopus synonyms Gene Function: cell cycle regulator Interactants: ins(30) , mapk1(23) , cdk2(21) , cdk1(17) , pcna(14) , pold1(14) , ccnb1.2(12) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002935777|PREDICTED: Xenopus (Silurana) tropicalis cyclin-dependent kinase inhibitor 1A (p21, Cip1), transcript variant 1 (cdkn1a), mRNA TTCGCTCGGGTTGTTTGTTGTGCCATCCCCGTGGATATTGCGCTGCTGTTTGCCAGACATATGAAAACAAATGAAAGAGAAAATGCAGTCAGCCATAGCCATCCTCAAGCAAGCATCTGGAAATAAGGAAAAGGCTTGTCGAATGCTTTTTGAAGCTGTGGACCATGAACAGCTAAAAACTGAATTTCATGAACTTATGCAGAGATCCAACGAGGAAGCAAAAGCTAAATGGAACTTTGACTTTGTCACTGAAACTCCTCTTGAAGGGCAATATGATTGGGAGAAGGTAGAAGACAAAACCTTGAATTGCAATTCGCAGGAAAGTGAAAAAGAAAACCAGTGCCAAGATGTAGCCGCAGAGATGTGTAACATTAACCAATCCCATAAAGCTTCCCAGAATTGTGAAAGCAGCGATTCAGGCAAAAGGAAACAAAAGCTGATCACAGATTTTTATCCTGTCAAGCGGAGATGTTCACCTAAACCCAGCCCCCGCGATTGATCACTATGCTGTTTGTGAGGTCCTTTCTTTGGACCTGAACAAATTTTCATTTCTCAGTTTAAGGTGTCAGAACGCTGGATTTTCATGCTCTTATACAAAACCTGGACTTTAATGGACATTACATAGACTCCAGAGAACTTCAAAATCCTCACAGATTGTACCTCACTATTACTTTAATAATTTAAACAACCGGAAGAAGAGATAAGCATTAGCTTTAGTGGTGTATGTTTGCTGAGTTTCTAGTTGTTGCAAAATACTTTTTTTGTAATTCTAAATAGTAAAACACTGCGGTTTTATAGATATATGTATATAAATGATACTAAGTTAATGAAAATGGCTAATATTTAGAAGTTTGCAACAGATTTTGACAAGATTCAGAGCAATATTCAGTAATGCACTAAAATGTTAGTCCATGTGTGCAGGCCACTTTGCTTTAGCACTCAGCATCATACCTTGGGGCTTTTTAAAGGGGACCATACACTGGATAATACTCTTCAGTATCCTACCAATCAGCCCTCTGGCTGAATTGGCGGCTACCATATGAGTGGCCATTTACATGTATGGCTGCCATACTAGTGTTCCATTTGTTTAATTAAACAATTGAAATAGCAGGAAGTGAAGAGGAGCTACAAATTTTCTTTACTCCTTCATCTATTGATGCATATTGCATCAGCAGATGAACAGATCAATATGTCAGAATAATATATCTGGGCATGTAAAGCCAGCTTAACTGTGCTAACACTGATATCTTTAAAATACTACCACCTGGAGGGTGGGTGGACATCATTTTCACGTCCAGTTGTTAAATGTTTTTCTTGCACTTACAGAGTTATTGTTTATTATAGCTATAAACAAACACAGAATAGGTTCTAAACACCTTAAGATATCCTAGATTGGGCTGCTAAGATACTGATCCTGTGCCATACCAACAAGAAGGCATCCAAGTATAATGCTCTAGAACAGCAGTTCCCACACTATAGGGCTGTCCCTCATAGGGGGGCTGGAGCAATGGAGCCATTAACGGAAAGATTTTAGATATTCTTGGAATAATGGCTGAGTTACTGAAAGCAAGGGTATTTCCTAATCTCTGTAACCTTGGTTTGGGATAAGGGGATCCCAGACCATATATTGAACTTCAAAAGGCAACTTGAACTTAATACCTATGAAAACCAATAGAAAGAAATCATTGTGGAAAATTCTAAATATGTCTACAGAGTAAGGACAGATTTTTTTGGACACCCCCTAGTATACTAGTGTTATTTATTACACCTTTAACACTGAACATTTTTAGAAGGAAATGTAACAATCATGTCATAAACCCTGCACAATTAAGGTTTCCAGCAATACATCCTCTACTAATCAGACTGGGATAATTGGCAATAGCGTCGAGCTCAGTGTAGAATGGAGCAATATCTGTTTAAGTTTTGTTTGGGGCATGTGCTAATATAAGGGAAAGGGATATTTTTATTTTAAAATATTTTAATTTATCTATGTGTATGTGTTAAATTTGTTGAATTGTTCTTATTTTATTAATATATAAAGTTCCCTTAAAATATTGCCAAAATGCTTGTAAATCGCATTTTTCAGAAAAGGGTGGAGCTGTTTTTCACCTAAAAAAGAACCATGTCATGTAGACTTTAGTAATCAAAATAGGTAATATAATAGTGCCTGTTTGTAAGCAGCAGACCAATAAATACTTCCTGTTGCTTGGTTATTATGGTTTACTAGACTTGGAACAATTTTGCACTTGTCACTCCTTCATCTGCTAAAGGGTTTTAGTTAACACTTTAAAGGGGACATATTGTGTGAGAAACAATATTGTGCGCATGAATTGTACTCACCTAATTATATAAGGAATGTGCTTTAAAAAGTAGTGTTTCGGGATGGTTTATTTGACATTTCTCCAAAACCCCA	Refseq >NM_001094464|Xenopus laevis cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a), mRNA CAGGCAAACGAAAACAAAAGCTGATCACAGAGAAAATGCAGTCTGCCTTAGCCATCCCCAAGCAAGCATCTGGGAATAAGGAAAAGTCTTGCAGAATGCTTTTTGGCCCCGTAGACCATGAACAGCTAAGAGCAGACTTTGATGAATTTATGCAGAAATCCAACGAGGAAGCAAAAGCTAAATGGAACTTTGGCTTTGCCACTGAAACACCCCTTGAAGGGCAATATGATTGGGTAAAGGTAGAAAACAACACCTTGAATGGCAGCTCTCAGGAAAGTCAAAAAGAAAACCAGTGCCAAGATGTAGCCACAGAGAGATGTAACATTAGCCCATCCTCTAAAGCGTTCCAGAATTGTGAAAGCAGCGATTCAGGCAAACGAAAACAAAAGCTGATCACAGATTTTTATCCTGTCAAGCGGAGATGTTCACCCGTGCCCAGCCTCCATGATTAATCACCATGCTGTTTACAAAGTCCTTCCTTTAGATATGAACAAAGTTTCATTTCTCAGATTCAAAGTGTAGGAACGTTGGATTTTCATGCTCTTATACAATACCTGGACTTTTATGGACATTGCATAGACTCCAGAGAACTACAAAACCCTTGTACCTCGCTATTACTTTAATAATTTAAACAGCCTGAGGAAGAGAAGAGCATTAGAATTAGAGGCGTGTAAAGGAAATGTGTTCTCAGTTTCTAGTTATTGCAAAATACTTTTTTTATTTTAAATAGTAAAACACTGCATTTTTATAGATATATGTATATAAATGAAACTTAAGTAAATTAATGAAAACGGTTAATATTTTGAAGTTTGCAACAGGTTTTCAGAGCAATATTCAAAAGTGCACTAAACTTATAGCACAGTTTTCTGTTTAAATTCATTCATTTGAAAATTACCATTTTGCCATATGTGCAACTTACTTTGCTTTCTGCACGTAGCATCATCCTTGGAGATTTTTAAATGGGACCATACAATAGGCCAGCTTAAATTAAAGTGAGAAAAAAGTTAATCACGTAAAAAGTCATGGACGAGATTCAATTTGTGATGCAATTCAGGTCAGAAAACATCTCACGGNTTATCACGTGAAAACTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >XP_002935823|PREDICTED: cyclin-dependent kinase inhibitor 1 isoform 1 [Xenopus (Silurana) tropicalis] MKEKMQSAIAILKQASGNKEKACRMLFEAVDHEQLKTEFHELMQRSNEEAKAKWNFDFVTETPLEGQYDWEKVEDKTLNCNSQESEKENQCQDVAAEMCNINQSHKASQNCESSDSGKRKQKLITDFYPVKRRCSPKPSPRD	Refseq >NP_001087933|cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Xenopus laevis] MQSALAIPKQASGNKEKSCRMLFGPVDHEQLRADFDEFMQKSNEEAKAKWNFGFATETPLEGQYDWVKVENNTLNGSSQESQKENQCQDVATERCNISPSSKAFQNCESSDSGKRKQKLITDFYPVKRRCSPVPSLHD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.16692	Xl.80306 [+] Xl.15415
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	CDKN1A
mouse		MGI	Cdkn1a	All(6) Targeted, knock Out(3) Targeted, other(2)
zebrafish		ZFIN	cdkn1a	10 Lines(s)

Publications
First:		ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae. [Nature 1983]
Most recent:		Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation. [Cell Div 2013]
		View All Papers 5 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		cyclin-dependent protein kinase inhibitor activity
Biological:		cell cycle arrest
Cellular Component:		nucleus
EC:
KOG:		[T] Cyclin-dependent kinase inhibitor

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.16692.1.S1_at
Affymetrix 2.0			Xl2.15415.1.S1_at

Symbol legend[+]

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