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XB-GENEPAGE-
487829
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Gene Symbol: hes4
Gene Name: hes family bHLH transcription factor 4 Synonyms: Xhairy2 , hairy2 , hairy2b , Xhairy2b , hairy2a , XHairy2a , hes4a , hes4b , H2 , hes4-a , hes4-b Add Xenopus synonyms , Nomenclature history Gene Function: helix-loop-helix transcription factor/transcriptional repressor Protein Function  :
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Plays a role in the patterning of tissue boundaries. Promotes floor plate development and prechordal plate development. Required for ...[+]
Interactants: Loading ... 
OMIM Disease Associations: |
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1/7 | Xenbase Gene ID | XB-GENE-487830 | XB-GENE-865740 | XB-GENE-6256031 | ||||||
| Gene Symbol | hes4 | hes4.L | hes4.S | ||||||
| Chromosome | Chr07 | chr7L | chr7S | ||||||
| Molecules | tropicalis | laevis.L | laevis.S | ||||||
| Gene |
Genomic sequence
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Genomic sequence
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Genomic sequence
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| CDS |
Gene model
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Entrez Gene
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Entrez Gene
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Entrez Gene
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| mRNA |
Refseq
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Refseq
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Refseq
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| Protein
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Refseq
Swiss-Prot
TrEMBL
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Refseq
Swiss-Prot
TrEMBL
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Refseq
Swiss-Prot
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| Genomic | tropicalis | laevis.L | laevis.S | ||||||
| Genome Browser |
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| Links |
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| Genomic Synteny | Genomicus | ||||||||
| Expression | tropicalis | laevis.L | laevis.S | ||||||
| Ensembl | Ensembl | ||||||||
| UniGene | Str.6018 [+] | Xl.1764 Xl.86822 | Xl.1764 | ||||||
| RNA-Seq profile | Stage profile: |
Stage profile:
Tissue heatmap:
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| Experimental regulation |
Regulation heatmap:
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| Images | 156 expression image(s) for tropicalis and laevis | ||||||||
| Data Mining | tropicalis | laevis.L | laevis.S | ||||||
| XenMine | hes4 | hes4.L | hes4.S | ||||||
| Phenotype | tropicalis | laevis.L | laevis.S | ||||||
| Smith Morpholino Screen | |||||||||
| Orthology |
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| Publications | |||||||||
| First: |
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. [Genes Dev 1994]
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| Most recent: | C8orf46 homolog encodes a novel protein Vexin that is required for neurogenesis in Xenopus laevis. [Dev Biol 2018] | ||||||||
| View All Papers 18 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs | |||||||||
| Functional Ontologies | tropicalis | laevis.L | laevis.S | ||||||
| GO | 19 terms | 18 terms | 14 terms | ||||||
| PANTHER | hes4 | ||||||||
| KEGG Pathways | K06054 | K06054 | K06054 | ||||||
| KOG |
[K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
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| Reagents | tropicalis | laevis.L | laevis.S | ||||||
| CRISPR / TALEN | CRISPR tools | CRISPR tools | CRISPR tools | ||||||
| Clones | EXRC - 1 clone(s) | ||||||||
| GE Dharmacon | GE Dharmacon | GE Dharmacon | |||||||
| Source BioScience | Source BioScience | Source BioScience | |||||||
| Morpholino | hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 | hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 | hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 | ||||||
| ORF | hes4 ORF1 | hes4 ORF2 | |||||||
| Affymetrix 1.0 | Str.43383.1.A1_at [+] | Xl.1764.1.S1_at | Xl.25977.1.S1_x_at [+] | ||||||
| Affymetrix 2.0 | Xl2.1764.1.S1_at | Xl2.25977.3.A1_at [+] | |||||||
Symbol legend[+]
