Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (97) GO Terms (27) Nucleotides (432) Proteins (49) Interactants (1279) Wiki
XB-GENEPAGE-487829
Gene Symbol:
hes4

Gene Name:
hes family bHLH transcription factor 4

Synonyms:
Xhairy2 , hairy2 , hairy2b , Xhairy2b , hairy2a , XHairy2a , hes4a , hes4b , H2 , hes4-a , hes4-b ( Add synonyms , Nomenclature history )

Gene Function:
helix-loop-helix transcription factor/transcriptional repressor

Protein Function :
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field ...[+]



Interactants:
Loading ...

Diseases: 


External Links:
1/9
 
Xenbase Gene ID XB-GENE-487830 XB-GENE-865740 XB-GENE-6256031
Gene Symbol hes4 hes4.L hes4.S
Chromosome Chr07 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 394465
398258
398579
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine hes4 hes4.L hes4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards HES4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
rat
zebrafish
chicken
GEISHA HES4 Ensembl
fruit fly
worm
Publications
First Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate., Genes Dev 1994          
Most Recent Nucleotide receptor P2RY4 is required for head formation via induction and maintenance of head organizer in Xenopus laevis., Dev Growth Differ 2019                        
All View All Papers 18 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 25 terms 18 terms 13 terms
PANTHER hes4
KEGG Pathways K06054 K06054 K06054
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks hes4
Morpholinos hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5
ORFs hes4.L ORF1 hes4.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556