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Summary Expression Gene Literature (100) GO Terms (31) Nucleotides (434) Proteins (54) Interactants (1295) Wiki
XB-GENEPAGE-487829
Gene Symbol:
hes4

Gene Name:
hes family bHLH transcription factor 4

Synonyms:
Xhairy2 , hairy2 , hairy2b , Xhairy2b , hairy2a , XHairy2a , hes4a , hes4b , H2 , hes4-a , hes4-b ( Add synonyms , Nomenclature history )

Gene Function:
helix-loop-helix transcription factor/transcriptional repressor

Protein Function :
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Plays a role in the patterning of tissue boundaries. Promotes floor plate development and prechordal plate development. Required for ...[+]


InterPro :
Peptidase C19 UCH , Papain-like cys pep sf , USP CS , USP dom [+]

Interactants:
Loading ...

Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-487830 XB-GENE-865740 XB-GENE-6256031
Gene Symbol hes4 hes4.L hes4.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 394465
398258
398579
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hes4 hes4.L hes4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards HES4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
rat
zebrafish
chicken
GEISHA HES4 Ensembl
fruit fly
worm
Publications
First Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate., Genes Dev 1994          
Most Recent Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage., Biol Open 2021                  
All View All Papers 18 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 28 terms 19 terms 13 terms
PANTHER hes4
KEGG Pathways K06054 K06054 K06054
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hes4
Morpholinos (on-target & off-target) hes4 MO1 , hes4 MO2 , hes4 MO4 , hes4 MO5
ORFs hes4.L ORF1 hes4.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info