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Summary Expression Gene Literature (88) GO Terms (20) Nucleotides (416) Proteins (37) Interactants (729) Wiki
XB-GENEPAGE- 487829

Gene Symbol: hes4

Gene Name: hes family bHLH transcription factor 4

Synonyms: Xhairy2 , hairy2 , hairy2b , Xhairy2b , hairy2a , XHairy2a , hes4a , hes4b , H2 , hes4-a , hes4-b
Add Xenopus synonyms , Nomenclature history


Gene Function: helix-loop-helix transcription factor/transcriptional repressor

Protein Function:
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field ...[+]


Interactants: YYY

OMIM Disease Associations:
1/7
 
Xenbase Gene ID XB-GENE-487830 XB-GENE-865740 XB-GENE-6256031
Gene Symbol hes4 hes4.L hes4.S
Chromosome scaffold_7 chr7L chr7S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.6018 [+] Xl.1764 Xl.86822 Xl.1764
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 149 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine hes4 hes4.L hes4.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards HES4 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, IMPC Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN
chicken
GEISHA HES4 Ensembl
fruit fly
worm
WORMBASE
Publications
First: Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. [Genes Dev 1994]
Most recent: Six1 and Eya1 both promote and arrest neuronal differentiation by activating multiple Notch pathway genes. [Dev Biol 2017]
View All Papers 18 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 18 terms 14 terms
EC
PANTHER hes4
KEGG Pathways K06054 K06054 K06054
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones     EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5 hes4 MO1 , hes4 MO2 , hes4 MO3 , hes4 MO4 , hes4 MO5
ORF hes4 ORF1 hes4 ORF2
Affymetrix 1.0 Str.43383.1.A1_at [+] Xl.1764.1.S1_at Xl.25977.1.S1_x_at [+]
Affymetrix 2.0 Xl2.1764.1.S1_at Xl2.25977.3.A1_at [+]

Symbol legend[+]

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