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Summary Expression Gene Literature (221) GO Terms (8) Nucleotides (94) Proteins (28) Interactants (576) Wiki
XB-GENEPAGE- 487965

Gene Symbol: nkx2-5

Gene Name: NK2 homeobox 5

Synonyms: tinman , csx , XNkx-2.5 , Nkx-2.5 , nkx2.5 , XNkx2-5 , nkx-2.5 , AR2 , nkx2-5-a , nkx2-5-b
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor with role in cardiac development

Protein Function:


Interactants: YYY

OMIM Disease Associations: TETRALOGY OF FALLOT; TOF [+]
1/6
 
Xenbase Gene ID XB-GENE-487966 XB-GENE-6464336 XB-GENE-865753
Gene Symbol nkx2-5 nkx2-5.L nkx2-5.S
Chromosome scaffold_3 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.38922 Xl.48440 Xl.22859
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 197 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine nkx2-5 nkx2-5.L nkx2-5.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NKX2-5 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Nkx2-5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN nkx2.5 ZFIN Ensembl
chicken
GEISHA NKX2-5 Ensembl
fruit fly
worm
WORMBASE
Publications
First: XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. [Dev Biol 1994]
Most recent: The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. [Dev Biol 2017]
View All Papers 37 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 8 terms 8 terms
EC
PANTHER nkx2-5
KEGG Pathways K09345 K09345 K09345
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s) EXRC - 1 clone(s) EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Transgene Tg(nkx2.5:GFP) Tg(nkx2.5:GFP) Tg(nkx2.5:GFP)
Morpholino nkx2-5 MO1 nkx2-5 MO1 nkx2-5 MO1
Affymetrix 1.0 Str.38922.1.A1_at Xl.1093.1.S1_at [+]
Affymetrix 2.0 Xl2.48440.1.S1_s_at Xl2.1093.1.S1_at [+]

Symbol legend[+]

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