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Summary Expression Gene Literature (236) GO Terms (20) Nucleotides (95) Proteins (35) Interactants (896) Wiki
XB-GENEPAGE-487965
Gene Symbol: nkx2-5

Gene Name: NK2 homeobox 5

Synonyms: tinman , csx , XNkx-2.5 , Nkx-2.5 , nkx2.5 , XNkx2-5 , nkx-2.5 , AR2 , nkx2-5-a , nkx2-5-b ( Add synonyms , Nomenclature history )

Gene Function: homeodomain transcription factor with role in cardiac development

Protein Function :
Implicated in commitment to and/or differentiation of the myocardial lineage. May regulate the expression of genes involved in cardiogenesis and play a role in the formation of gut and the pharyngeal r...[+]


Interactants: Loading ...
Disease Ontology: atrial heart septal defect 7 [+]

OMIM Diseases: CONOTRUNCAL HEART MALFORMATIONS; CTHM [+]

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Xenbase Gene ID XB-GENE-487966 XB-GENE-6464336 XB-GENE-865753
Gene Symbol nkx2-5 nkx2-5.L nkx2-5.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene: 100144646
Entrez Gene: 100337581
Entrez Gene: 379882
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL TrEMBL RefSeq TrEMBL TrEMBL RefSeq TrEMBL TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine nkx2-5 nkx2-5.L nkx2-5.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NKX2-5 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Nkx2-5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR nkx2.5 ZFIN Ensembl
chicken
GEISHA NKX2-5 Ensembl
fruit fly
worm
WORMBASE
Publications
First XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development., Dev Biol 1994    
Most Recent The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis., Dev Biol 2019                                    
All View All Papers 40 paper(s) referencing morpholinos 6 paper(s) referencing OMIMs 8 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 18 terms 8 terms 11 terms
PANTHER nkx2-5
KEGG Pathways K09345 K09345 K09345
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Horizon Horizon Horizon
Transgene Tg(nkx2.5:GFP) Tg(nkx2.5:GFP) Tg(nkx2.5:GFP)
Morpholino nkx2-5 MO1 nkx2-5 MO1 nkx2-5 MO1
Affymetrix 1.0 Str.38922.1.A1_at Xl.1093.1.S1_at [+]
Affymetrix 2.0 Xl2.48440.1.S1_s_at Xl2.1093.1.S1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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