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Summary Expression Gene Literature (229) GO Terms (15) Nucleotides (97) Proteins (29) Interactants (764) Wiki
XB-GENEPAGE- 487965

Gene Symbol: nkx2-5

Gene Name: NK2 homeobox 5

Synonyms: tinman , csx , XNkx-2.5 , Nkx-2.5 , nkx2.5 , XNkx2-5 , nkx-2.5 , AR2 , nkx2-5-a , nkx2-5-b
Add Xenopus synonyms , Nomenclature history


Gene Function: homeodomain transcription factor with role in cardiac development

Protein Function :


Interactants: Loading ...

Disease Ontology:
   ATRIAL HEART SEPTAL DEFECT 7 [+]

OMIM Diseases:
   CONOTRUNCAL HEART MALFORMATIONS; CTHM [+]
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Xenbase Gene ID XB-GENE-487966 XB-GENE-6464336 XB-GENE-865753
Gene Symbol nkx2-5 nkx2-5.L nkx2-5.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL TrEMBL Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.38922 Xl.48440 Xl.22859
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 205 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine nkx2-5 nkx2-5.L nkx2-5.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NKX2-5 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Nkx2-5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR nkx2.5 ZFIN Ensembl
chicken
GEISHA NKX2-5 Ensembl
fruit fly
worm
WORMBASE
Publications
First: XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. [Dev Biol 1994]
Most recent: Evaluation of the toxic effects of celecoxib on Xenopus embryo development. [Biochem Biophys Res Commun 2018]
View All Papers 37 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 15 terms 8 terms 8 terms
PANTHER nkx2-5
KEGG Pathways K09345 K09345 K09345
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s) EXRC - 1 clone(s) EXRC - 1 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Transgene Tg(nkx2.5:GFP) Tg(nkx2.5:GFP) Tg(nkx2.5:GFP)
Morpholino nkx2-5 MO1 nkx2-5 MO1 nkx2-5 MO1
Affymetrix 1.0 Str.38922.1.A1_at Xl.1093.1.S1_at [+]
Affymetrix 2.0 Xl2.48440.1.S1_s_at Xl2.1093.1.S1_at [+]

Symbol legend[+]
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