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Summary Expression Gene Literature (47) GO Terms (22) Nucleotides (192) Proteins (40) Interactants (572) Wiki
Gene Symbol: hes1

Gene Name: hes family bHLH transcription factor 1

Synonyms: hairy1 , Xhairy1 , hes-1 , hes1-a , hes1-b ( Add synonyms , Nomenclature history )

Gene Function: helix-loop-helix transcription factor/transcriptional repressor

Protein Function :
Transcriptional repressor of a subset of early mesodermal genes including myod1 and t/bra. Binds DNA on N-box motifs: 5'-CACNAG-3'. Acts as a negative regulator of myogenesis, mediating Notch signaling...[+]

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-487995 XB-GENE-865756 XB-GENE-6256448
Gene Symbol hes1 hes1.L hes1.S
Chromosome Chr05 chr5L chr5S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 496617
mRNA RefSeq RefSeq RefSeq
Protein RefSeq TrEMBL Swiss-Prot RefSeq Swiss-Prot TrEMBL RefSeq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine hes1 hes1.L hes1.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards HES1 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Hes1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR her6 ZFIN Ensembl
fruit fly
First Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons., Cell Tissue Res 1998  
Most Recent Recovery of the Xenopus laevis heart from ROS-induced stress utilizes conserved pathways of cardiac regeneration., Dev Growth Differ 2019                
All View All Papers 8 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 20 terms 13 terms 12 terms
KEGG Pathways K06054 K06054 K06054
KOG [K] Transcriptional repressors of the hairy/E(spl) family (contains HLH)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks hes1
Morpholinos hes1 MO1 hes1 MO1 hes1 MO1
ORFs hes1.L ORF1 hes1.S ORF1 , hes1.S ORF2
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.13.0

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