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Summary Expression Gene Literature (415) GO Terms (13) Nucleotides (93) Proteins (24) Interactants (2206) Wiki
Gene Symbol: shh

Gene Name: sonic hedgehog

Synonyms: hedgehog , Xhh , X-SHH , xshh , vhh-1 ( Add synonyms , Nomenclature history )

Gene Function: intercellular signaling, early embryo patterning

Protein Function :
The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into tw...[+]

Interactants: Loading ...
Diseases:  Disease Ontology: holoprosencephaly 3 [+]


External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-488039 XB-GENE-864913 XB-GENE-17341047
Gene Symbol shh shh.L shh.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100487601
mRNA NCBI Nucleotide RefSeq NCBI Nucleotide
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot NCBI Protein
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine shh shh.L shh.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards SHH OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR Shh MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
ZFIN, AGR ZFIN, AGR shha shhb ZFIN Ensembl
fruit fly
First Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord., Cell 1994    
Most Recent Hematopoiesis: from start to immune reconstitution potential., Stem Cell Res Ther null  
All View All Papers 49 paper(s) referencing morpholinos 11 paper(s) referencing OMIMs 19 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 9 terms 0 term
KEGG Pathways K11988
KOG [T] Sonic hedgehog and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks shh
Morpholinos shh MO1 , shh MO2 shh MO1 , shh MO2 shh MO1 , shh MO2
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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