shh Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (255)

Nucleotides (74)

Interactants (518)

XB-GENEPAGE-488038

Gene Symbol: shh Gene Name: sonic hedgehog Synonyms: hedgehog, Xhh, sonic hedgehog, X-SHH, xshh, vhh-1 Add Xenopus synonyms Gene Function: intercellular signaling, early embryo patterning Interactants: gli3(54) , gli1(37) , ptch1(35) , bmp4(34) , gli2(29) , chrd(26) , nodal(25) View All	1/3

XB-GENE-488039

XB-GENE-864913

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002932498\|PREDICTED: Xenopus (Silurana) tropicalis sonic hedgehog protein-like (LOC100487601), mRNA CCCTGCTTGCGCTTATTGCAATCGCAGCTTCTCATTTGCGCTTTAATTGCTGTGTCGCCTCTAAACCCCGATGTGTTCTGCTAGCGGGGACCTGCACACTGGGCTTTCTACACCTGCCTTGCTAGGGATCGGTGGCTAGTGGGGCCAGCCGGGAGGTACAAGGACACCCCAGTGCTCCAGCCAGTAGGGAGGCTGCAGCTCCACATCCTCCGAGCCTTTGATGTAATTGGCTTCGCTCGGACGAGATGCTGGTTGTGACTCGAATTCTGCTGCTGGGCTTCATCTGTACTCTGGTGGCCCCCCCTGGGCTGGCATGTGGACCTGGCAGAGGCATTGGCAAAAGGAGGCACCCTAAAAAACTCACCCCTTTAGCCTACAAGCAGTTCATCCCCAACGTGGCTGAGAAGACCCTGGGGGCCAGTGGTCGATACGAAGGAAAGATTACAAGGAACTCGGATCGATTTAAAGAGTTAACCCCCAATTATAACCCTGATATTATTTTTAAAGACGAGGAGAACACCGGAGCAGACCGACTCATGACTCAGAGATGTAAGGACAAGCTGAACGCCTTGGCGATCTCAGTGATGAACCAGTGGCCGGGGGTGAAGCTGCGGGTCACGGAGGGTTGGGATGAGGATGGGCACCACTCGGAGGAGTCGCTGCATTACGAGGGGAGAGCAGTGGACATTACCACGTCGGACCGGGACCGCAGTAAATACGGGATGCTGGCCAGGCTGGCGGTGGAAGCCGGGTTCGACTGGGTCTATTTTGAGTCCAAGGCTCACATCCACTGCTCGGTCAAAGCAGGAGGTGTGAAACTTCAGTCTCTGCTCACAGAGTCAGACATGCATGGCAAACATTCAAGAACAAATATACTGGAAGAAGAAAAACTGCCCAGATCCGAGTCGACGAGGCTCTCACAGTTTAGGGGGTGTGAAACTGTCCCTCTGTGGGCCCCCCTTCACTAA	Refseq >NM_001088313\|Xenopus laevis sonic hedgehog (shh), mRNA CGAGCAGAGATTGCCCATAATTACTGTCTCGTCTCTACACCCCCATGTGTTCTGTGAGCGGGGAGCTGCACCCTGGACTTTCTGCACCTGCCTTGCTTGGGATCGGTGGCTAGAGGGGTCGGCGAGGAGGCACAAGGTTGCTGGAAGCAGCAGCGAAGGAGAACATCCTCTGAGCCTTTGATGTAATTGGCTTCGCTCGGACGAGATGCTGGTTGCGAACTCGAATCTCTGTTGGCTGCTGAGCTTCATCTGCACCCTGGTGACCCCCCCTGGGCTGGCATGTGGACCTGGCCGAGGCATTGGCAAGAGGAGACACCCCAAAAAACTCACCCCTCTCGCCTATAAGCAGTTCATCCCCAACGTGGCGGAGAAGACCCTGGGGGCCAGCGGCAGATACGAAGGAAAGATTACAAGGAACTCGGATTGCTTTAAAGAATTAACCCCCAATTATAACCCAGATATTATGTTTAAAGACGAGGAGAGCACCGGGGCGGACCGGCTCATGACTCAGAGATGTAAAGACAAACTGAACGCACTCGCGATCTCCGTGATGAACCAGTGGCCGGGGGTGAAGCTGCGGGTGACGGAGGGGTGGGATGAGGACGGGCACCACTTGGAGGAGTCGCTACATTATGAGGGGAGGGCAGTGGACATCACTACGTCGGACCGGGACCGCAGTAAATACGGAATGTTGGGCCGACTGGCGGTGGAGGCCGGGTTCGACTGGGTCTATTACGAGTCCAAAGCTCATATTCACTGTTCGGTCAAAGCAGAGAACTCAGTGGCGGCCAAGTCTGGCGGGTGCTTCCCTGCTGGTGCCAGGGTGATGGTGGAATTTGGTGGCACCAAAGCGGTGAAAGACCTGCGACCAGGGGACCGCGTTCTCTCCTCCGACCCCCAAGGGAATCTGCTCTACAGCGACTTCCTCATGTTCATCGACCAGGAGCGTGACGTCAAGAAGCTCTTTTACGTCATCGAAACGTCTCAGAGAAAAATTCGGTTGACCGCGGCCCATCTACTTTTTGTGGCCCAGACCAAGGTCAACGGCACCAGGTCGTTCAAGTCTGTCTTTGCCAGCAACATCCAACCAGGAGATCTCATTTATACAGCAGAATCCCAAGACCATGACCTTGAAGGGCGGGGAAAGTGGAGAAGGTTGATCTTGAGGGAGGACACTGGAGCTTATGCGCCTCTAACTGCCCATGGGACTGTGGTTATAGACCAGGTATTGGCCTCCTGCTATGCAGTCATTGAGGAACACACCTGGGCACACCTCGCATTTGCGCCACTGAGGTTTGGCATGAGCCTCTCCTCTTATATTTACCCCAGAGACTCCAGTCCTCCATCAGGCCTTCAGCCTCACCACCAAGTTGACCTTCAGTCTCACCATCAAGTTGATCTTCAGTCTCACCACCAAGTTGACCTTCAGTCTCACCACCAACTTGAAGGCATCCACTGGTACTCCCAGCTACTGTATCAGATAGGGACTTGGCTTTTGGACAGTAGCTCCCTGCACCCACTGGGCATGGCAACGAAATCCAGTTGA
Protein		NCBI Protein >XP_002932544\|PREDICTED: sonic hedgehog protein-like [Xenopus (Silurana) tropicalis] MLVVTRILLLGFICTLVAPPGLACGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSDRFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYFESKAHIHCSVKAGGVKLQSLLTESDMHGKHSRTNILEEEKLPRSESTRLSQFRGCETVPLWAPLH	Refseq >NP_001081782\|sonic hedgehog protein precursor [Xenopus laevis] MLVANSNLCWLLSFICTLVTPPGLACGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSDCFKELTPNYNPDIMFKDEESTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHLEESLHYEGRAVDITTSDRDRSKYGMLGRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPAGARVMVEFGGTKAVKDLRPGDRVLSSDPQGNLLYSDFLMFIDQERDVKKLFYVIETSQRKIRLTAAHLLFVAQTKVNGTRSFKSVFASNIQPGDLIYTAESQDHDLEGRGKWRRLILREDTGAYAPLTAHGTVVIDQVLASCYAVIEEHTWAHLAFAPLRFGMSLSSYIYPRDSSPPSGLQPHHQVDLQSHHQVDLQSHHQVDLQSHHQLEGIHWYSQLLYQIGTWLLDSSSLHPLGMATKSS UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.47115 [+] Str.58639	Xl.866
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		50 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SHH	OMIM:120200 OMIM:142945 OMIM:147250 OMIM:174500 OMIM:611638
mouse		MGI	Shh	All(30) Targeted, knock Out(4) Targeted, other(14) Radiation Induced(1) Chemically Induced(8) Spontaneous(1)
zebrafish		ZFIN ZFIN	shha shhb	36 Lines(s) 9 Lines(s)

Publications
First:		Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. [Cell 1994]
Most recent:		The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo. [Dev Biol 2013]
		View All Papers 30 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		cell communication cell-cell signaling multicellular organismal development
Cellular Component:
EC:
KOG:		[T] Sonic hedgehog and related proteins

Reagents		tropicalis	laevis
Clones		EXRC - 2 clone(s)	EXRC - 1 clone(s)
		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.40140.2.S1_at [+] Str.40140.1.S1_at Str.40140.1.S1_a_at Str.46406.1.A1_x_at Str.46406.1.A1_at Str.47115.1.A1_at	Xl.866.1.S2_at
Affymetrix 2.0			Xl2.866.1.S2_at

Symbol legend[+]