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Summary Expression Gene Literature (424) GO Terms (16) Nucleotides (95) Proteins (27) Interactants (2241) Wiki
XB-GENEPAGE-488038
Gene Symbol:
shh

Gene Name:
sonic hedgehog

Synonyms:
hedgehog , Xhh , X-SHH , xshh , vhh-1 ( Add synonyms , Nomenclature history )

Gene Function:
intercellular signaling, early embryo patterning

Protein Function :
Intercellular signal essential for a variety of patterning events during development.


InterPro :
Ig sub2 , FN3 dom , Ig I-set , Contactin-5 [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
holoprosencephaly 3 [+]

OMIM:
SCHIZENCEPHALY [+]

External Links:
1/10
 
Xenbase Gene ID XB-GENE-488039 XB-GENE-864913 XB-GENE-17341047
Gene Symbol shh shh.L shh.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100487601
398047
108719826
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine shh shh.L shh.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards SHH OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Shh MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Shh Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR shha shhb ZFIN Ensembl
chicken
GEISHA SHH Ensembl
fruit fly
worm
Publications
First Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord., Cell 1994    
Most Recent Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience., Neuron 2021  
All View All Papers 49 paper(s) referencing morpholinos 14 paper(s) referencing OMIMs 25 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 9 terms 10 terms 8 terms
PANTHER shh
KEGG Pathways K11988 K11988
KOG [T] Sonic hedgehog and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks shh
Morpholinos (on-target & off-target) shh MO1 , shh MO2 shh MO1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info