Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (404) GO Terms (8) Nucleotides (77) Proteins (13) Interactants (2193) Wiki
XB-GENEPAGE-488038

Gene Symbol: shh

Gene Name: sonic hedgehog

Synonyms: hedgehog , Xhh , sonic hedgehog , X-SHH , xshh , vhh-1 ( Add Xenopus synonyms , Nomenclature history )

Gene Function: intercellular signaling, early embryo patterning

Protein Function :
Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the ful...[+]

Interactants: Loading ...
Disease Ontology: holoprosencephaly 3 [+]

OMIM Diseases: SCHIZENCEPHALY [+]

1/10
 
Xenbase Gene ID XB-GENE-488039 XB-GENE-864913 XB-GENE-17341047
Gene Symbol shh shh.L shh.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein TrEMBL RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine shh shh.L shh.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SHH OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Shh MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR ZFIN, AGR shha shhb ZFIN Ensembl
chicken
GEISHA SHH Ensembl
fruit fly
worm
WORMBASE
Publications
First Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord., Cell 1994    
Most Recent Hematopoiesis: from start to immune reconstitution potential., Stem Cell Res Ther null  
All View All Papers 48 paper(s) referencing morpholinos 10 paper(s) referencing OMIMs 18 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 8 terms 0 term 0 term
PANTHER shh
KEGG Pathways K11988
KOG [T] Sonic hedgehog and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones EXRC - 1 clone(s)    
Dharmacon Dharmacon Dharmacon
Morpholino shh MO1 , shh MO2 shh MO1 , shh MO2 shh MO1 , shh MO2
Affymetrix 1.0 Str.40140.2.S1_at [+] Xl.866.1.S2_at
Affymetrix 2.0 Xl2.866.1.S2_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.3


Major funding for Xenbase is provided by grant P41 HD064556