tgfb1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (465)

Nucleotides (63)

Interactants (448)

XB-GENEPAGE-488110

Gene Symbol: tgfb1 Gene Name: transforming growth factor, beta 1 Synonyms: tgfb5, TGF-beta5, ced, lap, dpd1, tgfb, tgfbeta, tgf-beta, tgf-beta 5, tgf beta Add Xenopus synonyms Gene Function: growth factor Interactants: nodal(93) , smad2(82) , bmp4(73) , smad4.2(62) , smad4.1(59) , gdf1(53) , smad1(40) View All

XB-GENE-488111

XB-GENE-865765

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002939387\|PREDICTED: Xenopus (Silurana) tropicalis transforming growth factor beta-1-like (LOC100498430), mRNA CAAATTACATTTAGAGGGGGGGAGTTGACTGCATACAAGGCACATATTCTATAAGCTCTGGAAGCCAACCAGGATCTCCCACACTGCTCAATGCCACTGCTTCATGAAGACGGGACAGCAACTTTCAGAACTGCTTTCAGCTTTTCTCACCAAGAGACCGTTCCATCTCTTTAACATAGTCACACAGTGTTCCAGTTGTAATTATGTTTTCATTTAATGGTGGCAGCAAAACCTCTCCTCTTTATTTTTAGGCCGGCACATGGTACTCTGAGCACAGCACATACAATGAATTAGGGCGTTTAAACTGACTGTAAGTCAATCTGAGCTGGTGCTGAGACTGCTGAAGGACATATAAATAAAAGGAAGCCATCCTAAAAACCTACAATCCAGAGCTACTTGACTTTTGTCGTGGAACACTGCATTATGGAGGTTCTTTGGATGCTGCCGGTGCTGTTGGTGCTGCATCTTTCCACTTTAACTATGTCCATGTCTACCTGTAAGACTGTGGATATGGAAGAAGTCAGAAAGAGAAGAATTGAAGCCATCAGGGGGCAAATTCTCAGCAAACTAAAACTGGACAGAACACCAGATGTAGACAGTGAGAACATGACAGTGCCGAGTGAAGCCATCTCCCTTTACAATAGCACCTTGGAGGTGATCAGAGAAAGAGCAGCCAAAGAAGAAGCTCCTGTGTGGCAAGAGCACAACATACAGGATTATTACGCAAAACAAGTTCACAGGTTCGAAAGCATAAATGAACTGAAAGAAAATGAATTTTTGTTTACATTTAATGCATCACATGTGAGGGAAAATGTGGGAATGAAGTCTCTCCTGCACCATGCTGAGCTGCGCATGTACAGAAAGAAGCAGACAGATAAAAATGTGGAACAAAGGATGGAACTCTATGCGGGTAATGGAACTGATTACTCAGGATACCTGGATAGCAAGTTCTTTACTGCAGTAACAGATGATGAGTGGGTGTCATTTGATGTTACAAAGACTGTGAATGAATGGCTGAACCATGCAGAGGAAAATGAAGAATTCAGGTTGAAACCTGCCTGCAAATGTTCAATAACTACACACAGCAAGGTTATAAGTATAGAAGGGTTTTCTATTTTGCGGGGAGACTTGATGAATTTGGGTGGTGATGACCTCAAGAAACCCTACCTCTTGATCACGTCAATGCCAGCAGAGCGAATTGACACTGTCTCACACTCACGGAGAAAGCGTGGGGTTGGACAGGAGTATTGCTTTGGAAATAGTGGGCCAAACTGCTGTGTGAAACCGCTTTACATAAATTTCCGGAAGGATCTAGGCTGGAAGTGGATCCATGAGCCTAAGGGATATGAAGCAAATTATTGTTTAGGAAATTGTCCTTACATCTGGAGCACAGATACTCAGTACAGCAAGGTGCTATCACTTTATAATCAGAACAACCCTGGTGCATCTATCTCTCCCTGCTGTGTTCCTGATGTCCTGGAGCCACTACCAATCATTTATTATGTTGGCCGCAATGCCAAGGTGGAGCAGCTTTCTAACATGGTGGTAAGGTCTTGCCACTGCAGCTGAGAAAAGCTTGGGGGCAGAAAGCAAAGCAAAGACATGGTACAGAATCCTAACAAACCACCTTACTGCTGCCAGTTGCCAACATGGATACCATGAAGTCAAGTCATGAAGATCAAGGAACCCTTTGATTTTACATATGCAAGGCACAAATGCCGAAAGCAGTTAGAAACAACGCAACCCACACATGGATTTAGGATTCATCTACAACAATACACCCTTGGTTACAATATCTGTGTTTCTGGACTTCACTGTTCAGTTACTGTATCGATTTTTTAGCACCCCACTACAGCTTTTATGAAAGTGCTTCCCTGCCAAAGGTTATGGACATATACCAAGTTTTGGCAAAGGCAAAATCTTGGTTCAGGGTAAAATAACTCATCTGAAGCATCCAGTCCATGTAAAGGGGTTTTATATACAGTTACGGCAGAGAAATAAGCAGTACTCCCCTTGATAAATAAACCGAAGGCCATTTTACAAGGGACAGAAAAAAACACAACCCCATTCTAGAGTATCTTTGGTGCCTATTGCATTATCGTTCAACAAATTAAAGAGTGATCCTTATTCAATAGATGCTGCCTTTCAGGTCACAACACAAAAATGCCTTACAGTATAGATTAATACATTTAATGCTGAGCACAGATTAGAGAATCTCAACTCTTTATAGATTGTATATTTATTAACATAAATAATTGCTAAATAAATAAAAGCTCGAGCATGTCTTAAGGTATATTGACAAAAAAAAATATTAAAAACTGTTTTTGGTAAAACATGGGTGTTCATCCATGTTCATATCAACTCTCCCAACTTGTAGAGCTATCAATATGTTAAAAAGAAACAAAAGGCATTTATTTACAAAGCCAGAATACAGGAATCAATCAGAAAAAGGAACCTATCGCTGCAGCCTCAGCTACAGGGCAGACCTGTAGGACAAAACTGGATGAAATACAGAATACAGAGTGCCACGTACAGGTACCCACTGAACAAAGAAGGAGCTAATAATTCCTGTTTAAAAGGAGAAGTTTTTTTTTTTACCTTTTTAAACTGTATTATTTTATAGTTTTTTTTTATATTTAAAATATTTTGTTTTAATGAGGAAAAATAAAAAGAGGTACATAAATA	Refseq >NM_001087861\|Xenopus laevis transforming growth factor, beta 1 (tgfb1), mRNA CCTTTAAGTTACAGCACACAGGAGGAAGCCAAGAGGGGGGGGTGGTGAGAATCATGTTTTAGCAAGCAGGGTTACAAGGGCCGTCAAATTACATTTAGAGGGGGGAGTTGACTGCATACAAGGCACATATTCTATAAGCTCTAGAAGTCAACCCGGATCTCTCACACTGCTCAATGCAACTGCTTCATGAAGACAGGACAGCAACTTTCAAAACTGCTTTCAGCTTTTCTCACCAAGAGACCGTTCCATCCCTTTAACATAAACACACAGTGTTCCAGTTGTAATTATGTTTTCGTTTAATGGTGGCAGCAAAACCTCTCCTCGTTTCTAAGTTGGCACATGGTACTCTGAGCACAGCACATATACAATGAATTGGGGCTGCTTAAACTGACTGGAAGTGAATCTGAGCTGGTGCTGAGACTGTTGAAGGACATAAAAGTAAAAGGAAACTATTCTAAAAACCTAAAGCCAGAAACTTGAATTTTGTTGTGGAACACTGCATCATGGAGGTTCTGTGGATGCTGCTGGTGCTATTGGTCCTGCATCTTTCCAGTTTAGCTATGTCCTTGTCTACCTGTAAGGCTGTGGATATGGAAGAAGTCAGGAAGAGGAGAATTGAAGCCATCAGGGGCCAAATTCTCAGCAAGCTAAAACTGGACAAAACACCAGATGTAGACAGCGAGAAGATGACAGTGCCCAGTGAAGCCATCTTCCTTTACAATAGCACCTTGGAGGTGATCAGAGAAAAAGCAACCAGAGAAGAAGAACATGTAGGGCATGATCAGAACATACAGGACTATTATGCAAAACAAGTTTACCGATTTGAAAGCATAACCGAACTGGAAGACCATGAATTTAAGTTTAAATTTAATGCTTCGCATGTGAGGGAGAATGTAGGTATGAACTCTCTTCTGCACCATGCTGAGCTGCGCATGTACAAGAAGCAGACAGATAAAAACATGGATCAAAGGATGGAACTATTCTGGAAATACCAGGAAAATGGGACCACTCACTCAAGATACCTGGAGAGCAAGTACATTACTCCAGTAACAGATGATGAGTGGATGTCATTTGATGTTACAAAGACTGTGAATGAATGGCTGAAACGTGCAGAGGAAAATGAACAATTCGGGTTGCAGCCTGCCTGCAAATGTCCCACCCCACAGGCCAAAGATATAGACATAGAAGGATTTCCTGCTTTACGTGGAGACTTGGCGAGTTTGAGTTCCAAAGAAAACACGAAACCCTACCTGATGATCACTTCGATGCCAGCTGAGCGTATTGACACAGTTACAAGCTCACGGAAAAAGCGAGGGGTTGGACAGGAGTATTGCTTTGGGAACAATGGGCCAAACTGCTGTGTGAAACCTCTTTACATAAATTTTCGGAAGGATCTAGGCTGGAAGTGGATCCATGAGCCTAAGGGATATGAAGCAAATTATTGTTTAGGAAATTGTCCTTACATCTGGAGCATGGATACTCAGTACAGCAAGGTGCTATCACTTTATAATCAGAACAATCCCGGTGCATCTATATCTCCCTGCTGTGTTCCTGATGTCTTGGAGCCACTGCCAATCATTTATTATGTTGGCCGCACTGCTAAAGTAGAGCAGCTCTCTAATATGGTGGTAAGGTCTTGCAACTGCAGCTGAGAAGAGCTTGGGGGCAGAAAGCAAAGCAAAGACATGGTACAGAACCCACAAACCACCTTACTGCTTTAACCAGTGTCGAAGAAGGAGACCATGTTGTCAAGTCATGAGGATCGATGAACCCGTTAATTCTACATCTGAAAAGAGCAAATGCTGAAAGCAGTTACTAACTTCACAGCCCACACATGGATTTAGGATTCTTCTACAGCAATACACCTTTGGTTACAATATCTGTATTCCTGCACTTCGCACCTCAGTTACTGTATCAAGTTTTTAGCTCTCTGCTACAGCTTTTATGAAAGTGCTTCCTTGCCAAAGGTTATGGACAAATCTTAAGTTTTGGCAACAGCAAAATCTGGGTTCAAGGTAAAGTCACTCATCTGAAAGCATCCAGTCCATCTAAAGGGGTTTTACATGGACTGGATAATACAGTTGTTATGGCAGAAAAATAAGGGATGTACCCCATGATAAATAAACAGAAGGCCAGCTAACAAGAGACAGACAAAAAAGGCAGAAACCCCTTCTAGAATTTGTTTGGTGGCTATTCCATTATTTTTATGGCAAGCTAAAGACTAATCCACATTCAAAAAATGCTGACAAGAATGCCTTACAGAGAAGTTAACCCACTCAATGCTGAGCACAGATTGGAGAATCACAAGGCTCTTTATAGATTGTGTATTTATTAACATATATAATTGCCACATAAAAGCTCAAGCATTTCGTATTAGACATATTAATGATAAAAAAATATTCACAACTGTTTTTGATAAAACATGGGGGTTCCCATGTTCATTTCTACTATCCCAACTTGTAGAGCTGTGAATGTGTTTAAAAGGAAACAAAGACAATGATTTACAAATCCAGAATATAGGATCATCAGAAAAGAAACATATGACTCTGCTGCAGGACTGACCTGTCAGATATAACCGGATGAAATACAGAAAGCCATGTGCAGGTACCCACTGAACAAAGAAGGGGCTAATAATTCCTGTTTAAATGAGAAGGGTTTTTTTTTTACCTTTTTAAATGGTCTTATTTTATATAGTTTTTTTTTTAATATTTAAAAGGTTTTGTTTTAATGAGGAAAAATAAAAAAGGTACATAC
Protein		NCBI Protein >XP_002939433\|PREDICTED: transforming growth factor beta-1-like [Xenopus (Silurana) tropicalis] MEVLWMLPVLLVLHLSTLTMSMSTCKTVDMEEVRKRRIEAIRGQILSKLKLDRTPDVDSENMTVPSEAISLYNSTLEVIRERAAKEEAPVWQEHNIQDYYAKQVHRFESINELKENEFLFTFNASHVRENVGMKSLLHHAELRMYRKKQTDKNVEQRMELYAGNGTDYSGYLDSKFFTAVTDDEWVSFDVTKTVNEWLNHAEENEEFRLKPACKCSITTHSKVISIEGFSILRGDLMNLGGDDLKKPYLLITSMPAERIDTVSHSRRKRGVGQEYCFGNSGPNCCVKPLYINFRKDLGWKWIHEPKGYEANYCLGNCPYIWSTDTQYSKVLSLYNQNNPGASISPCCVPDVLEPLPIIYYVGRNAKVEQLSNMVVRSCHCS	Refseq >NP_001081330\|transforming growth factor beta-1 precursor [Xenopus laevis] MEVLWMLLVLLVLHLSSLAMSLSTCKAVDMEEVRKRRIEAIRGQILSKLKLDKTPDVDSEKMTVPSEAIFLYNSTLEVIREKATREEEHVGHDQNIQDYYAKQVYRFESITELEDHEFKFKFNASHVRENVGMNSLLHHAELRMYKKQTDKNMDQRMELFWKYQENGTTHSRYLESKYITPVTDDEWMSFDVTKTVNEWLKRAEENEQFGLQPACKCPTPQAKDIDIEGFPALRGDLASLSSKENTKPYLMITSMPAERIDTVTSSRKKRGVGQEYCFGNNGPNCCVKPLYINFRKDLGWKWIHEPKGYEANYCLGNCPYIWSMDTQYSKVLSLYNQNNPGASISPCCVPDVLEPLPIIYYVGRTAKVEQLSNMVVRSCNCS UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.71279	Xl.861 [+] Xl.73811
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	TGFB1	OMIM:131300 OMIM:219700
mouse		MGI	Tgfb1	All(11) Targeted, knock Out(2) Targeted, other(8)
zebrafish		ZFIN	tgfb1a

Publications
First:		Time courses of late after-potentials following tetanus or single shock in skeletal muscle fibers. [Pflugers Arch 1982]
Most recent:		[Using of the luciferase reporter constructs for investigation of the capacity of Noggin2 protein to inhibit cell signaling pathways in early Xenopus laevis embryos]. [Bioorg Khim 2012]
		View All Papers 28 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		growth factor activity transforming growth factor beta receptor binding
Biological:		cell growth growth
Cellular Component:
EC:
KOG:		[T] Transforming growth factor beta, bone morphogenetic protein and related proteins

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.40392.1.S1_at [+] Str.40392.2.A1_x_at Str.40392.2.A1_at	Xl.861.1.S1_at
Affymetrix 2.0			Xl2.861.1.S1_at

Symbol legend[+]