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Summary Expression Gene Literature (40) GO Terms (28) Nucleotides (254) Proteins (38) Interactants (474) Wiki
XB-GENEPAGE-489916
Gene Symbol:
cxcr4

Gene Name:
C-X-C motif chemokine receptor 4

Synonyms:
xcxcr4 , fb22 , hm89 , lap3 , lcr1 , npyr , cd184 , lestr , npy3r , npyrl , hsy3rr , npyy3r , cxcr4-a , cxcr4-b ( Add synonyms , Nomenclature history )

Gene Function:
G protein-coupled receptor

Protein Function :
Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular level of calcium ions. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cel...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
WHIM syndrome

OMIM:
WHIM SYNDROME; WHIMS

External Links:
1/2
 
Xenbase Gene ID XB-GENE-489917 XB-GENE-489921 XB-GENE-6256540
Gene Symbol cxcr4 cxcr4.L cxcr4.S
Chromosome Chr9 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038176
100192360
380373
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine cxcr4 cxcr4.L cxcr4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards CXCR4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Cxcr4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Cxcr4 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR cxcr4b cxcr4a ZFIN Ensembl
chicken
GEISHA CXCR4 Ensembl
fruit fly
Publications
First Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis., J Neuroimmunol 1998  
Most Recent In vivo Neural Crest Cell Migration Is Controlled by "Mixotaxis"., Front Physiol 2020      
All View All Papers 8 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 24 terms 15 terms 15 terms
PANTHER cxcr4
KEGG Pathways K04189 K04189 K04189
KOG [T] G protein-coupled receptor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks cxcr4
Morpholinos cxcr4 MO2 , cxcr4 MO4 cxcr4 MO4 cxcr4 MO2 , cxcr4 MO4
ORFs cxcr4.L ORF1 cxcr4.S ORF1 , cxcr4.S ORF2
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info