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Summary Expression Gene Literature (680) GO Terms (29) Nucleotides (122) Proteins (46) Interactants (456) Wiki
XB-GENEPAGE-491845
Gene Symbol:
chek1

Gene Name:
checkpoint kinase 1

Synonyms:
Chk1 , XChk1 ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negative...[+]



Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-491846 XB-GENE-17335159 XB-GENE-866102
Gene Symbol chek1 chek1.L chek1.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038224
108696394
398191
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine chek1 chek1.L chek1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CHEK1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Chek1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Chek1 Ensembl
zebrafish
ZFIN, AGR chek1 ZFIN Ensembl
chicken
GEISHA CHEK1 Ensembl
fruit fly
worm
Publications
First The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts., J Cell Biol 1998              
Most Recent Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system., Cell Cycle 2020  
All View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 4 terms 22 terms
PANTHER chek1
KEGG Pathways K02216 K02216
KOG [D] Checkpoint kinase and related serine/threonine protein kinases
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks chek1
Antibodies Chek1 Ab1 Chek1 Ab1
Morpholinos chek1 MO1 chek1 MO1 chek1 MO1
ORFs chek1.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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