Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (68) GO Terms (21) Nucleotides (94) Proteins (30) Interactants (503) Wiki
XB-GENEPAGE-492511
Gene Symbol:
kit

Gene Name:
KIT proto-oncogene receptor tyrosine kinase

Synonyms:
c-kit , krk1 , pbt , scfr , xkl-1 , kit-a , kit-b ( Add synonyms , Nomenclature history )

Gene Function:
serine/threonine kinase

Protein Function :
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintena...[+]


InterPro :
Protein kinase ATP BS , Kinase-like dom sf , Prot kinase dom , Ig-like fold [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
testicular cancer [+]

OMIM:
LEUKEMIA, ACUTE MYELOID; AML [+]

External Links:
1/3
 
Xenbase Gene ID XB-GENE-492512 XB-GENE-6253062 XB-GENE-6252691
Gene Symbol kit kit.L kit.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100216090
373579
373772
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine kit kit.L kit.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards KIT OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Kit MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Kit Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR kita kitb ZFIN Ensembl
chicken
GEISHA KIT Ensembl
fruit fly
worm
Publications
First Mechanism of chromatin assembly in Xenopus oocytes., J Mol Biol 1986  
Most Recent Cardiac telocytes exist in the adult Xenopus tropicalis heart., J Cell Mol Med 2020                              
All View All Papers 8 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 8 terms 10 terms
PANTHER kit
KEGG Pathways K05091 K05091 K05091
KOG [T] Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks kit
Antibodies Kit Ab1 Kit Ab1 Kit Ab1
ORFs kit.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556