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Summary Expression Gene Literature (437) GO Terms (6) Nucleotides (222) Proteins (53) Interactants (804) Wiki
XB-GENEPAGE-493519
Gene Symbol:
axin2

Gene Name:
axin 2 (conductin, axil)

Synonyms:
axil , xarp ( Add synonyms , Nomenclature history )

Gene Function:
G protein signaling regulator

Protein Function :
Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.


InterPro :
HERPUD1/2 , Ubiquitin-like domsf , Ubiquitin-like dom , EF-hand-dom pair [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
tooth agenesis [+]

OMIM:
COLORECTAL CANCER; CRC [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-6449828 XB-GENE-6252887 XB-GENE-6253409
Gene Symbol axin2 axin2.L axin2.S
Chromosome Chr7 chr7L chr7S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100380149
373619
447702
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine axin2 axin2.L axin2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards AXIN2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Axin2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Axin2 Ensembl
zebrafish
ZFIN, AGR axin2 ZFIN Ensembl
chicken
GEISHA AXIN2 Ensembl
fruit fly
worm
Publications
First Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos., Mol Cell Biol 1998  
Most Recent The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020                                                                                                
All View All Papers 9 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 2 terms 6 terms 3 terms
PANTHER axin2
KEGG Pathways K04385 K04385 K04385
KOG [T] G protein signaling regulators
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks axin2
ORFs axin2.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list