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XB-GENEPAGE-493519
Gene Symbol:
axin2
Gene Name: axin 2 (conductin, axil)
Synonyms:
axil
,
xarp
( Gene Function: G protein signaling regulator Protein Function
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Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.
Interactants:
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Diseases: Disease Ontology:
tooth agenesis
OMIM:
COLORECTAL CANCER; CRC
External Links:
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Xenbase Gene ID | XB-GENE-6449828 | XB-GENE-6252887 | XB-GENE-6253409 | |||||
Gene Symbol | axin2 | axin2.L | axin2.S | Chromosome | Chr7 | chr7L | chr7S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100380149
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373619
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447702
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser) |
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Embryonic Protein Expression | Stage profile:![]() |
Stage profile:![]() |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | axin2 | axin2.L | axin2.S | |||||
Orthology |
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human |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos., Mol Cell Biol 1998 |
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Most Recent |
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer., Elife 2020 ![]() |
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All | View All Papers 9 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 2 terms | 6 terms | 3 terms | |||||
PANTHER | axin2 | |||||||
KEGG Pathways | K04385 | K04385 | K04385 | |||||
KOG |
[T] G protein signaling regulators
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | axin2 | |||||||
ORFs | axin2.S ORF1 | |||||||
Clones | EXRC Horizon Source BioScience | Horizon Source BioScience | Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
Symbol legend:



