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Summary Expression Gene Literature (8) GO Terms (9) Nucleotides (287) Proteins (33) Interactants (175) Wiki
XB-GENEPAGE- 493882

Gene Symbol: wdr5

Gene Name: WD repeat domain 5

Synonyms: xwdr5 , swd3 , big-3 , wdr5-a , wdr5-b
Add Xenopus synonyms , Nomenclature history


Gene Function: WD40 repeat-containing protein

Protein Function:
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation a...[+]


Interactants: YYY

OMIM Disease Associations:
 
Xenbase Gene ID XB-GENE-493883 XB-GENE-6255108 XB-GENE-866297
Gene Symbol wdr5 wdr5.L wdr5.S
Chromosome scaffold_8 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.29154 [+] Xl.48374 Xl.12820
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 6 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine wdr5 wdr5.L wdr5.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards WDR5 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Wdr5 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN wdr5 ZFIN Ensembl
chicken
GEISHA WDR5 Ensembl
fruit fly
worm
WORMBASE
Publications
First: WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. [Cell 2005]
Most recent: The MLL/Setd1b methyltransferase is required for the Spemann''s organizer gene activation in Xenopus. [Mech Dev 2016]
View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 9 terms 0 term 0 term
EC 1-alkyl-2-acetylglycerophosphocholine esterase
PANTHER wdr5
KEGG Pathways K14963 K14963 K14963
KOG [R] WD40 repeat-containing protein
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Morpholino wdr5 MO1 , wdr5 MO2 , wdr5 MO3 wdr5 MO1 , wdr5 MO2 , wdr5 MO3 wdr5 MO1 , wdr5 MO2 , wdr5 MO3
ORF wdr5 ORF1
Affymetrix 1.0 StrJgi.1994.1.S1_at [+]
Affymetrix 2.0 Xl2.48374.1.S1_at Xl2.12820.1.S1_at

Symbol legend[+]

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