Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (2) GO Terms (11) Nucleotides (55) Proteins (19) Interactants (428) Wiki
XB-GENEPAGE- 493996

Gene Symbol: vhl

Gene Name: von Hippel-Lindau tumor suppressor

Synonyms: vhl1
Add Xenopus synonyms , Nomenclature history


Gene Function: E3 ubiquitin ligase

Protein Function:


Interactants: YYY

OMIM Disease Associations: PHEOCHROMOCYTOMA PHEOCHROMOCYTOMA, SUSCEPTIBILITY TO [+]
 
Xenbase Gene ID XB-GENE-493997 XB-GENE-17344358 XB-GENE-6487931
Gene Symbol vhl vhl.L vhl.S
Chromosome scaffold_4 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 9.1 JBrowse 9.1 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA Refseq
Protein Refseq TrEMBL TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
GBrowse
tropicalis genome v7.1 gene model
GBrowse
laevis genome v9.1 gene model
GBrowse
laevis genome v9.1 gene model
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.26933 Xl.46865
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Images 4 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine vhl vhl.L vhl.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tegg131f10      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards VHL OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Vhl MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN vhl ZFIN Ensembl
chicken
GEISHA VHL Ensembl
fruit fly
FLYBASE Vhl Ensembl
worm
WORMBASE
Publications
First: Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. [PLoS Genet 2006]
Most recent: Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. [Nat Cell Biol 2008]
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 0 term 0 term
EC
PANTHER vhl
KEGG Pathways K03871 K03871
KOG [O] E3 ubiquitin ligase, VHL component (von Hippel-Lindau tumor suppressor in humans)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino vhl MO1 vhl MO1 vhl MO1
Affymetrix 1.0 Str.26933.1.S1_at
Affymetrix 2.0 Xl2.46865.1.S1_at

Symbol legend[+]

My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556