Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (199) GO Terms (26) Nucleotides (376) Proteins (64) Interactants (179) Wiki
XB-GENEPAGE-494199
Gene Symbol:
grin1

Gene Name:
glutamate ionotropic receptor NMDA type subunit 1

Synonyms:
NR1 , nmda1 , nmdar1 ( Add synonyms , Nomenclature history )

Gene Function:
glutamate receptor channel component

Protein Function :
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requi...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal dominant non-syndromic intellectual disability 8

OMIM:
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-494200 XB-GENE-866327 XB-GENE-17335935
Gene Symbol grin1 grin1.L grin1.S
Chromosome scaffold_347 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.1
CDS Gene model Gene model
Entrez Gene 780048
397953
mRNA RefSeq RefSeq
Protein RefSeq RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine grin1 grin1.L grin1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GRIN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Grin1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Grin1 Ensembl
zebrafish
chicken
GEISHA GRIN1 Ensembl
fruit fly
worm
Publications
First Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs., Nature 1992  
Most Recent De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases., Hum Mutat 2019  
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 22 terms 11 terms 0 term
PANTHER grin1
KEGG Pathways K05208 K05208
KOG [PET] NMDA selective glutamate-gated ion channel receptor subunit GRIN1
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks grin1
Antibodies Grin1 Ab1 Grin1 Ab1 Grin1 Ab1
Morpholinos grin1 MO1 , grin1 MO2 grin1 MO1 , grin1 MO2 grin1 MO1 , grin1 MO2
ORFs grin1 ORF1
Clones Horizon Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556