Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (229) GO Terms (0) Nucleotides (76) Proteins (16) Interactants (758) Wiki
Gene Symbol: h2ac21

Gene Name: H2A clustered histone 21

Synonyms: h2a , XH2AX , H2AX , hist2h2ab ( Add synonyms , Nomenclature history )

Gene Function: Histone 2A

Protein Function :
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA...[+]

Interactants: Loading ...
Diseases:  External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
Xenbase Gene ID XB-GENE-5719327 XB-GENE-22066267 XB-GENE-22066269
Gene Symbol h2ac21 h2ac21.L h2ac21.S
Chromosome Chr09
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1
CDS Gene model
Entrez Gene 594911
mRNA RefSeq
Protein RefSeq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine h2ac21 h2ac21.L h2ac21.S
MOD Entrez Gene Genetic Phenotypes Gene Expression
OMIM:Gene, HGNC, GeneCards H2AC21 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
MGI, AGR H2ac21 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
fruit fly
First Reiteration frequency of the histone genes in the genome of the amphibian, Xenopus laevis., Eur J Biochem 1976  
Most Recent Modeling Bainbridge-Ropers Syndrome in Xenopus laevis Embryos., Front Physiol 2020            
All View All Papers 2 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term 0 term
PANTHER h2ac21
KEGG Pathways
KOG [B] Histone 2A
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks h2ac21
Morpholinos hist2h2ab MO1 hist2h2ab MO1 hist2h2ab MO1
Clones Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.13.1
Major funding for Xenbase is provided by grant P41 HD064556