Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (18) GO Terms (16) Nucleotides (204) Proteins (35) Interactants (389) Wiki
XB-GENEPAGE-5759105
Gene Symbol:
vcl

Gene Name:
vinculin

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
cytoskeletal protein

Protein Function :
Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane.


InterPro :
Argonaute hook dom , Nucleotide-bd a/b plait sf , TNRC6A RRM , TNRC6 PABC-bd [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
dilated cardiomyopathy 1W

OMIM:
CARDIOMYOPATHY, DILATED, 1W; CMD1W [+]

External Links:
 
Xenbase Gene ID XB-GENE-5759106 XB-GENE-17331397 XB-GENE-5759162
Gene Symbol vcl vcl.L vcl.S
Chromosome Chr07 Scaffold19
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100036705
373770
mRNA RefSeq NCBI Nucleotide
Protein RefSeq NCBI Protein
Genomic
 tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine vcl vcl.L vcl.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards VCL OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Vcl MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Vcl Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR vcla vclb ZFIN Ensembl
chicken
GEISHA VCL Ensembl
fruit fly
worm
Publications
First Cytoskeletal components of the vertebrate neuromuscular junction: vinculin, alpha-actinin, and filamin., J Cell Biol 1983            
Most Recent Grp94 regulates the recruitment of aneural AChR clusters for the assembly of postsynaptic specializations by modulating ADF/cofilin activity and turnover., eNeuro 2020  
All View All Papers 2 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 11 terms 0 term 7 terms
PANTHER vcl
KEGG Pathways K05700
KOG [W] Alpha-catenin
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks vcl
Antibodies Vcl Ab1 , Vcl Ab2 , Vcl Ab3 Vcl Ab2 , Vcl Ab3 Vcl Ab1 , Vcl Ab2 , Vcl Ab3
Morpholinos vcl MO1 vcl MO1 vcl MO1
Clones Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.14.0
Major funding for Xenbase is provided by grant P41 HD064556