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Summary Expression Gene Literature (3) GO Terms (8) Nucleotides (106) Proteins (23) Interactants (15) Wiki
XB-GENEPAGE- 5910468

Gene Symbol: cfap298

Gene Name: cilia and flagella associated protein 298

Synonyms: kur , kurly , c21orf59
Add Xenopus synonyms , Nomenclature history


Gene Function: This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function.

Protein Function :
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:26904945). Seems to be important for initiation rather than maintenance of cilium motility. Required for ...[+]


Interactants: Loading ...

Disease Ontology:
   PRIMARY CILIARY DYSKINESIA 26

OMIM Diseases:
   CILIARY DYSKINESIA, PRIMARY, 26; CILD26
 

Xenbase Gene ID XB-GENE-5910469 XB-GENE-5910499 XB-GENE-17342827
Gene Symbol cfap298 cfap298.L cfap298.S
Chromosome Chr02 chr2L chr2S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.53349 Xl.4468
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine cfap298 cfap298.L cfap298.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards CFAP298 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Cfap298 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR cfap298 ZFIN Ensembl
chicken
fruit fly
worm
WORMBASE
Publications
First: Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants. [Dev Biol 2008]
Most recent: c21orf59/kurly Controls Both Cilia Motility and Polarization. [Cell Rep 2016]
View All Papers 1 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 5 terms 3 terms 0 term
PANTHER cfap298
KEGG Pathways
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Morpholino c21orf59 MO1 , c21orf59 MO2 , c21orf59 MO3 c21orf59 MO1 , c21orf59 MO2 , c21orf59 MO3 c21orf59 MO1 , c21orf59 MO2 , c21orf59 MO3
ORF cfap298.L ORF1
Affymetrix 1.0 Str.11895.1.S1_at Xl.4468.1.S1_at
Affymetrix 2.0 Xl2.4468.1.S1_at

Symbol legend[+]
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