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Summary Expression Gene Literature (11) GO Terms (20) Nucleotides (96) Proteins (35) Interactants (250) Wiki
XB-GENEPAGE-5959107
Gene Symbol:
lgr4

Gene Name:
leucine-rich repeat containing G protein-coupled receptor 4

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
glycoprotein hormone receptor

Protein Function :
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates wi...[+]



Interactants:
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Diseases: 


OMIM:
BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 17; BMND17

External Links:
 
Xenbase Gene ID XB-GENE-5959108 XB-GENE-17346282 XB-GENE-5959148
Gene Symbol lgr4 lgr4.L lgr4.S
Chromosome Chr04 chr4L chr4S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100144922
108713818
734948
mRNA RefSeq NCBI Nucleotide RefSeq
Protein RefSeq Swiss-Prot Swiss-Prot NCBI Protein RefSeq
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine lgr4 lgr4.L lgr4.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards LGR4 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Lgr4 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Lgr4 Ensembl
zebrafish
lgr4 Ensembl
chicken
GEISHA LGR4 Ensembl
fruit fly
FLYBASE Lgr4 Ensembl
worm
Publications
First Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis., PLoS One 2010                      
Most Recent RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6., Nature 2018    
All View All Papers 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 17 terms 3 terms 11 terms
PANTHER lgr4
KEGG Pathways K04309 K04309 K04309
KOG [T] Glycoprotein hormone receptor
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks lgr4
Morpholinos lgr4 MO1 , lgr4 MO2 , lgr4 MO3 lgr4 MO1 , lgr4 MO2 , lgr4 MO3 lgr4 MO1 , lgr4 MO2 , lgr4 MO3
Clones Horizon Source BioScience Horizon Horizon Source BioScience

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