Gene Symbol: smad4.2 [provisional] Gene Name: SMAD family member 4, gene 2 [provisional] Synonyms: XSmad4alpha, xsmad4, jip, dpc4, madh4, smad10 Add Xenopus synonyms Gene Function: TGFbeta receptor signaling protein SMAD and related proteins Interactants: smad4.1(89) , tgfb1(62) , smad2(59) , smad1(35) , smad3(29) , foxh1(16) , mix1(12) View All

Molecules		tropicalis	laevis a		laevis b
Gene		JGI XT Genome 4.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene		Entrez Gene
mRNA		NCBI Nucleotide >XM_002944012|PREDICTED: Xenopus (Silurana) tropicalis SMAD family member 4, gene 2 (smad4.2), mRNA TTCACATTGGGAAGGGGGTGCAGCTTGAGTGTCGGGGAGAGGGCGACGTGTGGATGAGGTGCCTCAGTGACCACGCGGTGTTCGTGCAGAGTTATTACCTGGACAGGGAGGCGGGGCGAGCGCCGGGGGACGCCGTGCACAAGATTTACCCGGGCGCCTACATTAAGGTGTTCGACTTGCGTCAGTGCCACCGACAGATGCAGCAACAGGCGGCTACGGCTCAAGCAGCGGCGGCGGCCCAAGCGGCGGCCGTGGCCGGCACAATACCCGGCCCTGGGTCAGTGGGTGGCATCGCCCCTGCTGTCAGCCTGTCTGCTGCCGCCGGCATCGGGGTGGACGACCTGCGGCGCCTCTGTATCTTGCGCCTGAGTTTCGTCAAGGGGTGGGGCCCCGATTACCCCCGGCAGAGCATCAAGCAGACCCCCTGCTGGATAGAGGTCCACCTTCACCGTGCCCTGCAGCTTCTGGATGAAGTTCTCCATACGTTGCCAATGGCCGACCCCAGCTCCGTCAACTAACCAATGGCAGACCCCGAGCTCTCGTCAGCCAGCCAATGGCAGACCGGCTTCCAAGGCCCGGGTGAGACGTGACCAAGAACGAGCCAATCAGGATTCATCAGATTTTTAGCTCAAGAACAACCTTTGCTATAGACTTGTGGTCTCGGCTGAACCATTGGGCACGGGGGGAACCGCTAACCTCCCCTTGGATCTTCCCGCTGATGGGTGGAACCCGTCGGACTGTAGTTGGGCTGATCCGGGCCCCGAGGCGCAGAACCTTGGGGTGACAGAGAGGAACTGTGTTTTTATGGCTTAAATGTCCCTTATTTTTTTGGTCAGAAGATTTATTTTTGGTCTGATATTTAGCACTTGGCTCTTTGGTGCCTGGAGGACACCCCCCCAGCTGTTTCCCTGGCGTTTAAAGGGTAAATAAAATGCAGATAGTATAAATGCTTTTTTTTAATGTGCCGTTTAAAATGATGTGGCTACCTCAGCCCCCCCCTCCCCCCTCTGCCTGGGCTCCTCTCTCACTGCCCCCCCAGCCATTTTGCCCCCCCATTCCCGCCCCATTGGTACTAACACGTGGCCTTTGCTGCTTTTCCAATGCTTGGGATTTGTTTGTTTTTTTAGCAGCAACCACATTTATTTGTTTTGTATTGTGGTATCATTTCCAGGCCAAATGTGCTACCGAACAGCAGCGCCGTGTGTGCAGCCCAAAGGGTTCCCATTATACAGAACCTGCCCAATAGCTTCCGACGTATTCTAAATAAAATATTTATGTACTGTTACTTATAA	Refseq >NM_001090918|Xenopus laevis SMAD family member 4, gene 2 (smad4.2-a), mRNA GTCGACGTCAGGGGCGGGGAGAGAGTGTGAGGGAAAGAGAGAGAAGAGACAGTCAGGGGATTGGGATAGAGTGAGAGGGAGACAGTCAGGGATTGTGTATGAGGGAGAAGAGACTTGGGCAGTGAGAGAATGAGGGAGTAGGATATCAGGGAGTGGGATAGAGTGAGAGGAGAGTGAGAGGAGAGTGAGATGGAGACAGTGGGGCCCATAGAGACATAATAGGAATGAGGGAGAGCACTGGGGGAATAGGAGACACTTCCTGTACTTGTAGGTTGGTAGGGACAGTTCTGACTGAGCAGTAATGGCTCCTCCTGATAGAGACTGAGTGAGAGGAGCTGCCACACACGAGATCCCGGCCATGTCTCTGACCCCTCCTAACAGCAGTGATGCCTGTCTCAGCATCGTACACAGTCTCATGTGCCACCGGCAGGGGGGGGAGAACGAGGGCTTTGCCAAGAGAGCCATTGAGAGTCTCGTCAAGAAACTGAAGGAGAAGAAAGACGAGCTGGACTCCCTCATCACTGCCATTACTACTAATGGAGTGCACCCCAGCAAGTGCGTTACCATCCAGCGAACCTTGGACGGGAGGCTTCAGGTAGCCGGCCGTAAAGGTTTCCCACATGTGATCTACGCTCGTTTGTGGCGCTGGCCGGACCTGCACAAGAATGAGCTGAAACACGTTAAGTTCTGCCAGTTCGCCTTCGACCTGAAGTACGACAGCGTGTGCGTGAACCCCTATCACTACGAGCGGGTGGTTTCTCCCGGCATTGGTCTGAGTATCCCTAGCACTGTGACCACCCCATGCCGGTCAGTAAAAGAGGAGTATGTCCATGAGTGTGAAATGGATGCATCTTCATGTCTCCCAGCATCCCAGGAACTTCCGCCAGCCATCAAACATGCCTCCCTTCCACCAATGCCTCCTACAGAGTCCTACAGGCAGCCACTGCCCCCACTCACCCTACCCAAGAGCCCCCAGACTGCTATCAGCATGTATCCCAACATGCCCCTCTCTCCCTCTGTGGCTCCTGGTTGCCCTCTCATACCTATGCATGGTGAGGGGTTACTACAGATAGCTCCATCCCATCCCCAGCAAATGTTGTCCATATCTCCGCCTTCCACACCGAGCCAGAACTCCCAGCAGAATGGTTATTCTTCCCCCCCAAAGCAGCCTTTCCATGCTTCTTGGACAGGGAGCAGCACAGCTGTATATACCCCGAACCCTGGGGTACAGCAGAACGGAAGAGGAAACCAGCAACCTCCACTTCACCACCCAAACAACTACTGGCCCCTTCACCAGAGCTCCCCTCAGTATCAGCACCCCGTGTCAAACCACCCAGGCCCAGAGTTCTGGTGCTCCGTTGCCTATTTCGAGATGGATGTTCAGGTTGGGGAGATATTTAAAGTCCCATCTAACTGTCCCGTGGTCACGGTGGATGGATATGTGGACCCCTCTGGTGGGGATCGGTTTTGCCTTGGTCAGCTTTCTAACGTGCATCGCACAGACACTAGTGAGCGTGCAAGGCTTCACATCGGGAAGGGAGTGCAGCTTGAGTGTCGGGGCGAGGGAGACGTATGGATGAGGTGCCTCAGTGATCACGCCGTGTTTGTTCAGAGTTATTACTTGGACAGGGAAGCAGGGCGAGCGCCGGGAGATGCAGTCCACAAGATTTATCCGGGCGCCTACATTAAGGTGTTTGACTTGCGACAGTGTCACCGGCAGATGCAGCAGCAGGCGGCTACGGCTCAAGCAGCGGCTGCAGCCCAAGCGGCGGCTGTGGCCGGCGCAATCCCTGGTCCCGGGTCAGTGGGGGGCATCGCTCCTGCTGTCAGTCTTTCTGCTGCGGCCGGTATCGGGGTGGACGACCTACGGCGCCTCTGTATCTTGCGCCTTAGTTTTGTGAAGGGCTGGGGCCCTGATTACCCTCGGCAGAGCATCAAGCAGACTCCCTGCTGGATCGAGGTCCATCTTCACCGTGCGCTGCAGCTTCTTGATGAAGTTCTCCATACTTTGCCAATGGCAGACCCCAGTTCTGTCAACTAACCAAGACCCCGAGGTCTGTCAGATTGCCAGTGGCAGACTAACTGTCAACTACCAAAGCCAGGATGAGACAAGACTCCTAATTAAGACTCATCCAGTCCAAAGTGAGCCAATCAGGATTCATCCAATCATATGTTAAGCAAAGACAAATGTTTGCCATAGACCTTCCAGTCCTTTGGAGACCCGGCCAATACATTGGGCACACGCCCCCTTGGATCTTCCTGCTGATTGGTGGAACCAGTAGGATGGAGGCACAGAACTCCCCCGAGTGGAGCTACACAGGACATGTGACTTTGGGTGAAGTAGATGAACTGTGTTTTTATAGCTGAAATGCATTAAATGTTCCTTATTTTTTTGGTCAGAAGATTATTTTTGGTCTGATATTTGGCTTTTTAGTGCCGGGACGGACTCCCAACATTTCCCTGACGTTCAAAGGCTAAATAAATGCAGATATATAAATGCTTTTTGTATGTGCCAGTTAAAATGATGTGGCTACCTCAGTTCCTTTAGCCCCCCATTCCCCCTCCCTTCCCCCTCCATTGGTACTAACACGTCTAACAGACAAGCAGGATCTGCTGGTTTACACGGCACACACATGTTCTACGCTGCTTTCCAAAGCCTGGGGAGATATTTGGTGTATTTTGATGTCTGTTTTCGGCGAGCGCATTTTTATTTTTTGTTGTGGTATCACTTCTAGGCCAAATGTGTACAGATAAAACCAAAAACCACAGCCGTGTGTAAAAAAGGTTTCTTTTCACATATTAAGAACCTGTCAAATGGCTTCTGATGTATTCTAAATAAAATATTTATGTACTGTTAAAAAAAAAAAAAAAAAAAAAAAAGTCGAC		Refseq >NM_001090989|Xenopus laevis SMAD family member 4, gene 2 (smad4.2-b), mRNA GAGCATGTATTTAAATGAATCACTTAGCAGCATATCATTGTTTAACAGAAGGAAGGGCTAAAGTTGTAATGTAGCTGGATCTAAATTAGCATGAATTACTCCTATTAGTAATGTTAGTCTGGTGGGGGAGGGGAGATGGGCTGCACCTGGATCCACGCTGAGAATTGAGCTGTGCCACTGAGCATGCTCTGGCTTTTTGTACCACTAATTGGTTCAGTCCAATAAACCCCATGGAGGTGTAACAACAAGGGCAAAAGATGGCGTTTGCCAGCCTAGAGCTCGCCCTGCACCGAGTGCCCCCCGCCCGGTGTGGAGATGAGGAGATCTACGGGGAAGGCTTGTCTGAGGGGGAGATCCCGGCCATGTCTCTGACCCCTCCTAACAGCAGTGATGCCTGTCTCAGCATCGTACACAGTCTCATGTGCCACCGGCAGGGGGGGGAGAACGAGGGCTTTGCCAAGAGAGCCATTGAGAGTCTCGTCAAGAAACTGAAGGAGAAGAAAGACGAGCTGGACTCCCTCATCACTGCCATTACTACTAATGGAGTGCACCCCAGCAAGTGCGTTACCATCCAGCGAACCTTGGACGGGAGGCTTCAGGTAGCCGGCCGTAAAGGTTTCCCACATGTGATCTACGCTCGTTTGTGGCACTGGCCGGACCTGCACAAGAATGAGCTGAAACACGTTAAGTTCTGCCAGTTCGCCTTCGACCTGAAGTACGACAGCGTGTGCGTGAACCCCTATCACTACGAGCGGGTGGTTTCTCCCGGCATTGGTCTGAGTATCCCTAGCACTGTGACCACCCCATGCCGGTCAGTAAAAGAGGAGTATGTCCATGAGTGTGAAATGGATGCATCTTCATGTCTCCCAGCATCCCAGGAACTTCCGCCAGCCATCAAACATGCCTCCCTTCCACCAATGCCTCCTACAGAGTCCTACAGGCAGCCACTGCCCCCACTCACCCTACCCAAGAGCCCCCAGACTGCTATCAGCATGTATCCCAACATGCCCCTCTCTCCCTCTGTGGCTCCTGGTTGCCCTCTCATACCTATGCATGGTGAGGGGTTACTACAGATAGCTCCATCCCATCCCCAGCAAATGTTGTCCATATCTCCGCCTTCCACACCGAGCCAGAACTCCCAGCAGAATGGTTATTCTTCCCCCCCAAAGCAGCCTTTCCATGCTTCTTGGACAGGGAGCAGCACAGCTGTATATACCCCGAACCCTGGGGTACAGCAGAACGGAAAAGGAAACCAGCAACCTCCACTTCACCACGCCAACAACTACTGGCCCCTTCACCAGAGCTCCCCTCAGTATCAGCACCCCGTGTCAAACCACCCAGGCCCAGAGTTCTGGTGCTCCGTTGCCTATTTCGAGATGGATGTTCAGGTTGGGGAGATATTTAAAGTCCCATCTAACTGTCCCGTGGTCACGGTGGATGGATATGTGGACCCCTCTGGTGGGGATCGGTTTTGCCTTGGTCAGCTTTCTAACGTGCATCGCACAGACACTAGTGAGCGTGCAAGGCTTCACATCGGGAAGGGAGTGCAGCTTGAGTGTCGGGGCGAGGGAGACGTATGGATGAGGTGCCTCAGTGATCACGCCGTGTTTGTTCAGAGTTATTACTTGGACAGGGAAGCAGGGCGAGCGCCGGGAGATGCAGTCCACAAGATTTATCCAGGCGCCTACATTAAGGTGTTTGACTTGCGACAGTGTCACCGGCAGATGCAGCAGCAGGCGGCTACGGCTCAAGCAGCGGCTGCAGCCCAAGCGGCGGCTGTGGCCGGCGCAATCCCTGGTCCCGGGTCGGTGGGGGGCATCGCTCCTGCTGTCAGTCTTTCTGCTGCGGCCGGTATCGGGGTGGACGACCTACGGCGCCTCTGTATCTTGCGCCTTAGTTTTGTGAAGGGCTGGGGCCCTGATTACCCTCGGCAGAGCATCAAGCAGACTCCCTGCTGGATCGAGGTCCATCTTCACCGTGCGCTGCAGCTTCTTGATGAAGTTCTCCATACTTTGCCAATGGCAGACCCCAGTTCTGTCAACTAACCAAGACCCCGAGGTCTGTCAGATTGCCAGTGGCAGACTAACTGTCAACTACCAAAGCCAGGATGAGACAAGACTCCTAATTAAGACTCATCCAGTCCAAAGTGAGCCAATCAGGATTCATCCAATCATATGTTAAGCAAAGACAAATGTTTGCCATAGACCTTCCAGTCCTTTGGAGACCCGGCCAATACATTGGGCACACGGATACCTGACGCCCCCTTGGTCCTTCCTGCTGATTGGTGGAACCAGTAGGATGGAGGCACAGAACTCCCCCGAGTGGAGATACACAGGACATGTGACTTTGGGTGAAGTAGATGAACTGTGTTTTTATAGCTGAAATGCATTAAATGTTCCTTATTTTTTTGGTCAGAAGATTATTTTTGGTCTGATATTTGGCTTTTTAGTGCCGGGACGGACTCCCAACATTTCCCTGACGTTCAAAGGCTAAATAAATGCAGATATATAAATGCTTTTTGTATGTGCCAGTTAAAATGATGTGGCTACCTCAGTTCCTTTAGCCCCCCATTCCCCCTCCATTGGTACTAACACGTCTAACAGACAAGCAGGATCTGCTGGTTTACACGGCACACACATGTTTTACGCTGCTTTCCAAAGCCTGGGGAGATATTTGGTGTATTTTGATGTCTGTTTTCGGCGAGCGCATTTTTATTTTTTGTTGTGGTATCACTTCTAGGCCAAATGTGTACAGATAAAACCAAAAACCACAGCCGTGTGTGCAAAGGTTTCTTTTCACATATTAAGAACCTGTCAAATGGCTTCTGATGTATTCTAAATAAAATATTTATGTACTGTTGCCTATAAAAAAAAAAAACG
Protein		NCBI Protein >XP_002944058|PREDICTED: mothers against decapentaplegic homolog 4 [Xenopus (Silurana) tropicalis] MRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGTIPGPGSVGGIAPAVSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKQTPCWIEVHLHRALQLLDEVLHTLPMADPSSVN	Refseq >NP_001084387|SMAD family member 4, gene 2 [Xenopus laevis] MSLTPPNSSDACLSIVHSLMCHRQGGENEGFAKRAIESLVKKLKEKKDELDSLITAITTNGVHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKFCQFAFDLKYDSVCVNPYHYERVVSPGIGLSIPSTVTTPCRSVKEEYVHECEMDASSCLPASQELPPAIKHASLPPMPPTESYRQPLPPLTLPKSPQTAISMYPNMPLSPSVAPGCPLIPMHGEGLLQIAPSHPQQMLSISPPSTPSQNSQQNGYSSPPKQPFHASWTGSSTAVYTPNPGVQQNGRGNQQPPLHHPNNYWPLHQSSPQYQHPVSNHPGPEFWCSVAYFEMDVQVGEIFKVPSNCPVVTVDGYVDPSGGDRFCLGQLSNVHRTDTSERARLHIGKGVQLECRGEGDVWMRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGAIPGPGSVGGIAPAVSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKQTPCWIEVHLHRALQLLDEVLHTLPMADPSSVN		Refseq >NP_001084458|SMAD family member 4, gene 2 [Xenopus laevis] MAFASLELALHRVPPARCGDEEIYGEGLSEGEIPAMSLTPPNSSDACLSIVHSLMCHRQGGENEGFAKRAIESLVKKLKEKKDELDSLITAITTNGVHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWHWPDLHKNELKHVKFCQFAFDLKYDSVCVNPYHYERVVSPGIGLSIPSTVTTPCRSVKEEYVHECEMDASSCLPASQELPPAIKHASLPPMPPTESYRQPLPPLTLPKSPQTAISMYPNMPLSPSVAPGCPLIPMHGEGLLQIAPSHPQQMLSISPPSTPSQNSQQNGYSSPPKQPFHASWTGSSTAVYTPNPGVQQNGKGNQQPPLHHANNYWPLHQSSPQYQHPVSNHPGPEFWCSVAYFEMDVQVGEIFKVPSNCPVVTVDGYVDPSGGDRFCLGQLSNVHRTDTSERARLHIGKGVQLECRGEGDVWMRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGAIPGPGSVGGIAPAVSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKQTPCWIEVHLHRALQLLDEVLHTLPMADPSSVN

Genomic		tropicalis
Genome Browser		Xenbase JGI Ensembl UCSC			Xenbase
Synteny		Metazome

Expression		tropicalis	laevis a		laevis b
UniGene		Str.4458	Xl.886		Xl.35419
Unigene EST Profile		EST Profile	EST Profile		EST Profile
GEO data			GEO		GEO
Images		4 expression image(s) for tropicalis and laevis

Phenotype		tropicalis	laevis a		laevis b
Smith Morpholino Screen		tegg032k01

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SMAD4	OMIM:174900 OMIM:175050
mouse		MGI	Smad4	All(20) Targeted, knock Out(9) Targeted, other(6) Chemically Induced(4) Spontaneous(1)
zebrafish		ZFIN	smad4

Publications
First:		A human Mad protein acting as a BMP-regulated transcriptional activator. [Nature 1996]
Most recent:		Brain-specific promoter/exon I.f of the cyp19a1 (aromatase) gene in Xenopus laevis. [J Steroid Biochem Mol Biol 2012]
		View All Papers 10 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		intracellular
EC:
KOG:		[TK] TGFbeta receptor signaling protein SMAD and related proteins

Reagents		tropicalis	laevis a		laevis b
Clones			EXRC - 2 clone(s)
		open biosystems	open biosystems		open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes		geneservice/RZPD imagenes
Affymetrix 1.0		Str.4458.1.S1_at	Xl.886.2.S1_a_at
Affymetrix 2.0			Xl2.886.1.S1_s_at

Symbol legend[+]

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