Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (122) GO Terms (9) Nucleotides (120) Proteins (12) Interactants (557) Wiki
XB-GENEPAGE- 5995151

Gene Symbol: smad4.2

Gene Name: SMAD family member 4, gene 2

Synonyms: xsmad4 , jip , dpc4 , madh4 , smad10 , XSmad4b , XSmad4beta , Smad4b , Smad4beta , smad4.2-a , smad4.2-b
Add Xenopus synonyms , Nomenclature history

Gene Function: TGFbeta receptor signaling protein SMAD and related proteins

Protein Function :


Interactants: Loading ...

Disease Ontology:
   JUVENILE POLYPOSIS SYNDROME [+]

OMIM Diseases:
   PANCREATIC CANCER [+]
 

Xenbase Gene ID XB-GENE-5995152 XB-GENE-6256010 XB-GENE-5995204
Gene Symbol smad4.2 smad4.2.L smad4.2.S
Chromosome scaffold_6425 chr8L chr8S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq Refseq
Protein TrEMBL TrEMBL Refseq TrEMBL Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus PANTHER
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.4458 Xl.35419 Xl.886
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 9 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine smad4.2 smad4.2.L smad4.2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen tegg032k01      
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards SMAD4 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Smad4 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR smad4a ZFIN Ensembl
chicken
GEISHA SMAD4 Ensembl
fruit fly
worm
WORMBASE
Publications
First: A human Mad protein acting as a BMP-regulated transcriptional activator. [Nature 1996]
Most recent: Eomesodermin-At Dawn of Cell Fate Decisions During Early Embryogenesis. [Curr Top Dev Biol 2017]
View All Papers 19 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 7 terms 7 terms 7 terms
PANTHER smad4.2
KEGG Pathways K04501 K04501
KOG [TK] TGFbeta receptor signaling protein SMAD and related proteins
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones     EXRC - 2 clone(s)
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Antibody Smad4 Ab1 Smad4 Ab1 Smad4 Ab1
Morpholino smad4.2 MO1 , smad4.2 MO2 , smad4.2 MO3 smad4.2 MO1 , smad4.2 MO2 , smad4.2 MO3 smad4.2 MO1 , smad4.2 MO2 , smad4.2 MO3
ORF smad4.2.S ORF1
Affymetrix 1.0 Str.4458.1.S1_at Xl.886.2.S1_a_at
Affymetrix 2.0 Xl2.886.1.S1_s_at

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.2
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556