Gene Symbol: diaph1 [provisional] Gene Name: diaphanous homolog 1 [provisional] Synonyms: drf1, dia1, dfna1, lfhl1, diap1 Add Xenopus synonyms Gene Function: RhoA GTPase effector DIA/Diaphanous Interactants: cdc7(6) , dbf4(5) , dbf4b(5) , antxr1(3) , atr(3) , chek1(2) , clspn(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		NCBI Nucleotide >CR761764|Xenopus tropicalis finished cDNA, clone TGas117k20 AAGCAGCTTGTTCGCTTGAGCCGCTGTCCAGCAAGGCCCGGGGTTATAGCGACAGCATGGAACCGCCAGCCGGTGGAGGCGGATATGGAGGGGGACCCCCGCCACCTTCCAAGGGCAACAAGGAGAAGAAGAAGCCGAAGGGCCAAGATGAAGGTGGAGATGGCAAGTCCAAGAAATTTCTTGAACGATTTACCAGTATACGGATGAAGAAAGAAAAGGAAAAGCCTTATCCATCACACAGAAACTCCACCAACTTCCCAGATAACTCAAACCCCCTCCAAACCTTGCAGGAACTCGAAGATGATGTTGTGCTTCAGCTGTTTGAAAAAATGCTGGATGATATGAACCTCAATCCTGAGAAGCAGCAACCGCTACGAGAAAAGGATATAATGATAAAAAGAGAGATGGTTTCCCAATATCTTCACACATCCAAAGCTGGCATGAGCAAAAAGGAGAGTTCTCGTTCTGCATTAATGTACATTCAAGACTTAAAATCCGGACTAGGAGACAATTCCCTCCTTTTGTGCTTAGAGTCACTAAGAGTATCTTTAAATAACAATCCTGTCAGCTGGGTGCAGAATTTTGGTGCAGAGGGTCTTTCGTGCCTTTTAGAAATTCTCAAAAGAATACAGGATGAGCAAGCATCCTTGCGGGATGTTAGAAGCGAGCATGAGATCATCAGATGTCTGAAAGCTTTTATGAATAACAATTTTGGAATTAAGGCAATGCTGGGCACAGAAGATGGCATTTTGCTGTTAGCGAGAGCAGTAGATCGATCTGTCCCTGCAATGATGATTGATTCCTTGAAGCTGCTTTCTGCCCTGTGCATCCTGCCACAACCAGAGGACATGCATGAGCGTGTTCTAGAAGCCCTTACGGAGAGAGCAGAGATGGAGGAAATGGAACGATTTAAACCTCTTCTGGATGGGTTAAACATTGCAAGTCCTGTGGCCTTGAAGGTGAGCTGTATGCAGCTAATCAATGCAGTGATCAGCCAAGGAGAAGAGCTTGATTACAGAGTTCACATCCGAAGTGAATTGATGCGCTCGGGACTGGCCAAACTCCTAAAGGAACTACGTAATACAGAAAATGAAGACCTGAAGGTACAACTTGGTATTTTTGATGAGCATTCTGAACTTGATTCTGATGACTTGCGAGGACGTTTGGACGACATCCGCATTGAAATGGATGACTTCAGTGACGTCTTCCAAGTTCTTCTGAACACTGTCAAGGACTCCTCTGCAGAACCATTATTTCTTTCCATCCTGCAGCATCTTCTTCTAATTAGAAATGATTATGATGCCAGGCCGCAGTACTATAAACTGATAGATGAAGTTATATCACAGATAATCCTTCAAAAAAATGGGGCTGATCCAGATTTCAAATGCAAGCATGTAAACATAGAAATCGAAAATCTGATAGATCATTTTATCGACAAAAAAAAAAAAAAAAAA
Protein		NCBI Protein >CAJ81540|diaphanous homolog 1 (Drosophila) [Xenopus tropicalis] MEPPAGGGGYGGGPPPPSKGNKEKKKPKGQDEGGDGKSKKFLERFTSIRMKKEKEKPYPSHRNSTNFPDNSNPLQTLQELEDDVVLQLFEKMLDDMNLNPEKQQPLREKDIMIKREMVSQYLHTSKAGMSKKESSRSALMYIQDLKSGLGDNSLLLCLESLRVSLNNNPVSWVQNFGAEGLSCLLEILKRIQDEQASLRDVRSEHEIIRCLKAFMNNNFGIKAMLGTEDGILLLARAVDRSVPAMMIDSLKLLSALCILPQPEDMHERVLEALTERAEMEEMERFKPLLDGLNIASPVALKVSCMQLINAVISQGEELDYRVHIRSELMRSGLAKLLKELRNTENEDLKVQLGIFDEHSELDSDDLRGRLDDIRIEMDDFSDVFQVLLNTVKDSSAEPLFLSILQHLLLIRNDYDARPQYYKLIDEVISQIILQKNGADPDFKCKHVNIEIENLIDHFID

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.15019
Unigene EST Profile		EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	DIAPH1	OMIM:124900
mouse		MGI	Diap1	All(5) Targeted, knock Out(2) Targeted, other(2)
zebrafish

Publications
First:		Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. [J Biol Chem 2003]
Most recent:		XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. [Mol Cell 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		actin binding
Biological:		cellular component organization and biogenesis
Cellular Component:
EC:
KOG:		[TZ] RhoA GTPase effector DIA/Diaphanous

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		Str.15019.1.S1_at
Affymetrix 2.0

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