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Summary Expression Gene Literature (46) GO Terms (12) Nucleotides (122) Proteins (30) Interactants (416) Wiki
XB-GENEPAGE-6049694
Gene Symbol:
clcnkb

Gene Name:
chloride channel, voltage-sensitive Kb

Synonyms:
clckb , clk-k2 , clc-kb , xClC-k , ClC-k , clcnka ( Add synonyms , Nomenclature history )

Gene Function:
Cl- channel CLC-2 and related proteins (CLC superfamily)

Protein Function :
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, the stabilization of membrane potential, signal transduction and transepithelial transp...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
Bartter disease type 3 [+]

OMIM:
BARTTER SYNDROME, TYPE 3; BARTS3 [+]

External Links:
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Xenbase Gene ID XB-GENE-6049695 XB-GENE-6252397 XB-GENE-17335868
Gene Symbol clcnkb clcnkb.L clcnkb.S
Chromosome scaffold_523 chr7L
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2
CDS Gene model Gene model
Entrez Gene 100487225
378616
mRNA NCBI Nucleotide RefSeq
Protein NCBI Protein RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine clcnkb clcnkb.L clcnkb.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CLCNKB OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Clcnkb MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Clcnkb Ensembl
zebrafish
chicken
GEISHA CLCNKB Ensembl
fruit fly
worm
Publications
First Expression and targeting to the plasma membrane of xClC-K, a chloride channel specifically expressed in distinct tubule segments of Xenopus laevis kidney., Biochem J 1999  
Most Recent Analysis of CLCNKB mutations at dimer-interface, calcium-binding site, and pore reveals a variety of functional alterations in ClC-Kb channel leading to Bartter syndrome., Hum Mutat 2020  
All View All Papers 6 paper(s) referencing morpholinos 5 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 7 terms 0 term
PANTHER clcnkb
KEGG Pathways K05018
KOG [P] Cl- channel CLC-2 and related proteins (CLC superfamily)
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks clcnkb
ORFs clcnkb.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience

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