Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (150) GO Terms (14) Nucleotides (239) Proteins (80) Interactants (914) Wiki
XB-GENEPAGE-6069999
Gene Symbol:
grb2

Gene Name:
growth factor receptor bound protein 2

Synonyms:
Grb3-3 , MST084 , MSTP084 , EGFRBP-GRB2 , grb2-a , grb2-b ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation.


InterPro :
SNCAIP SNCA-bd , Ankyrin rpt , Ankyrin rpt-contain sf , SNCAIP [+]

Interactants:
Loading ...

Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-6070000 XB-GENE-6253891 XB-GENE-6070021
Gene Symbol grb2 grb2.L grb2.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 493492
399458
444095
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine grb2 grb2.L grb2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GRB2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Grb2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Grb2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR grb2b grb2a ZFIN Ensembl
chicken
GEISHA GRB2 Ensembl
fruit fly
worm
Publications
First Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes., J Biol Chem 1994  
Most Recent Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis., Cell Rep 2020                  
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 11 terms 11 terms
PANTHER grb2
KEGG Pathways K04364 K04364 K04364
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks grb2
ORFs grb2 ORF1 grb2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list