Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (49) GO Terms (23) Nucleotides (495) Proteins (58) Interactants (972) Wiki
XB-GENEPAGE-6258352
Gene Symbol:
col2a1

Gene Name:
collagen, type II, alpha 1

Synonyms:
col11a3 , xcol2a1 , X-col II , col2a1-a , col2a1-b ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive fo...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
otospondylomegaepiphyseal dysplasia, autosomal recessive [+]

OMIM:
COLLAGEN, TYPE II, ALPHA-1; COL2A1 [+]

External Links:
1/4
 
Xenbase Gene ID XB-GENE-6258353 XB-GENE-6252613 XB-GENE-6252612
Gene Symbol col2a1 col2a1.L col2a1.S
Chromosome Chr02 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 394828
397738
397739
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine col2a1 col2a1.L col2a1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, COL2A1 Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Col2a1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Col2a1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR col2a1a col2a1b ZFIN Ensembl
chicken
GEISHA COL2A1 Ensembl
fruit fly
worm
Publications
First Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts., J Cell Biol 1991                  
Most Recent Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome., Hum Mol Genet 2020                    
All View All Papers 3 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 4 terms 3 terms
PANTHER col2a1
KEGG Pathways K19719 K19719 K19719
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks col2a1
Antibodies Col2a1 Ab1 , Col2a1 Ab2 Col1a1 Ab1 , Col2a1 Ab1 , Col2a1 Ab2 Col1a1 Ab1 , Col2a1 Ab1 , Col2a1 Ab2
ORFs col2a1.L ORF1 col2a1.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
Xenbase: The Xenopus Model Organism Knowledgebase.
Version: 4.15.0
Major funding for Xenbase is provided by grant P41 HD064556