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Summary Expression Gene Literature (35) GO Terms (8) Nucleotides (59) Proteins (20) Interactants (96) Wiki
XB-GENEPAGE-6447551
Gene Symbol:
scn2a

Gene Name:
sodium channel, voltage gated, type II alpha subunit

Synonyms:
nav1.2 , na(v)1.2 ( Add synonyms , Nomenclature history )

Gene Function:
Voltage-gated Ca2+ channels, alpha1 subunits

Protein Function :


InterPro :
Leu-rich rpt , Leu-rich rpt typical-subtyp , EPTP , EAR [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
West syndrome [+]

OMIM:
GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1; GEFSP1 [+]

External Links:
 
Xenbase Gene ID XB-GENE-6447552 XB-GENE-17342821 XB-GENE-17342822
Gene Symbol scn2a scn2a.L scn2a.S
Chromosome Chr9 chr9_10L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model
Entrez Gene 100486750
mRNA NCBI Nucleotide
Protein NCBI Protein NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine scn2a scn2a.L scn2a.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards SCN2A OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Scn2a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Scn2a Ensembl
zebrafish
chicken
GEISHA SCN2A Ensembl
fruit fly
Publications
First A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities., Neuroscience 2001  
Most Recent Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience., Neuron 2021  
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 8 terms 0 term 0 term
PANTHER scn2a
KEGG Pathways
KOG [PT] Voltage-gated Ca2+ channels, alpha1 subunits
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks scn2a
Clones Horizon Source BioScience
Plasmids Addgene Addgene

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