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Summary Expression Gene Literature (2) GO Terms (11) Nucleotides (36) Proteins (17) Interactants (80) Wiki
XB-GENEPAGE-6462751
Gene Symbol:
ago3

Gene Name:
argonaute 3, RISC catalytic component

Synonyms:
Argonaute3 , argonaute 3 ( Add synonyms , Nomenclature history )

Gene Function:
Translation initiation factor 2C (eIF-2C) and related proteins

Protein Function :
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and d...[+]


InterPro :
Ig-like fold , Ig-like dom sf , FAM187A/B , Ig-like dom

Interactants:
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Diseases: 


External Links:
 
Xenbase Gene ID XB-GENE-6462752 XB-GENE-17336810 XB-GENE-6488275
Gene Symbol ago3 ago3.L ago3.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model
Entrez Gene 100486574
mRNA NCBI Nucleotide
Protein NCBI Protein NCBI Protein
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ago3 ago3.L ago3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards AGO3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ago3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ago3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR ago3b ago3a ZFIN Ensembl
chicken
GEISHA AGO3 Ensembl
fruit fly
FLYBASE AGO3 Ensembl
worm
Publications
First Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability., Nat Cell Biol 2009          
Most Recent Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes., Curr Biol 2018                    
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 0 term 0 term
PANTHER ago3
KEGG Pathways
KOG [J] Translation initiation factor 2C (eIF-2C) and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ago3
Clones Horizon
Plasmids Addgene Addgene

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