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Summary Expression Gene Literature (31) GO Terms (19) Nucleotides (142) Proteins (52) Interactants (463) Wiki
XB-GENEPAGE-852890
Gene Symbol:
dlx2

Gene Name:
distal-less homeobox 2

Synonyms:
X-dll4 , tes1 , tes-1 , Xdll4 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain and LIM zinc binding domain transcription factor

Protein Function :
Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sproutin...[+]



Interactants:
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Diseases: 


External Links:
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Xenbase Gene ID XB-GENE-852891 XB-GENE-852896 XB-GENE-17342444
Gene Symbol dlx2 dlx2.L dlx2.S
Chromosome Chr09 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 493423
399264
734247
mRNA RefSeq RefSeq RefSeq
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine dlx2 dlx2.L dlx2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards DLX2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Dlx2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Dlx2 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR dlx2a dlx2b ZFIN Ensembl
chicken
GEISHA DLX2 Ensembl
fruit fly
worm
Publications
First Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals., Development 1993            
Most Recent Latrophilin2 is involved in neural crest cell migration and placode patterning in Xenopus laevis., Int J Dev Biol 2019                      
All View All Papers 8 paper(s) referencing morpholinos 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 15 terms 7 terms 3 terms
PANTHER dlx2
KEGG Pathways K18488 K18488 K18488
KOG [K] Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks dlx2
Antibodies Dlx2 Ab1 Dlx2 Ab1
ORFs dlx2 ORF1 dlx2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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