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Summary Expression Gene Literature (308) GO Terms (37) Nucleotides (69) Proteins (36) Interactants (810) Wiki
XB-GENEPAGE-853971
Gene Symbol:
cftr

Gene Name:
cystic fibrosis transmembrane conductance regulator

Synonyms:
xcftr , mrp7 , abc35 , abcc7 , cftr/mrp , tnr-cftr , cftr-a , cftr-b ( Add synonyms , Nomenclature history )

Gene Function:
ABC transporter

Protein Function :
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Chan...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
cystic fibrosis [+]

OMIM:
PANCREATITIS, HEREDITARY; PCTT [+]

External Links:
 
Xenbase Gene ID XB-GENE-853972 XB-GENE-866530 XB-GENE-6466536
Gene Symbol cftr cftr.L cftr.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100486085
373725
108712361
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining tropicalis laevis.L laevis.S
XenMine cftr cftr.L cftr.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards CFTR OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Cftr MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Cftr Ensembl
zebrafish
ZFIN, AGR cftr ZFIN Ensembl
chicken
GEISHA CFTR Ensembl
fruit fly
worm
Publications
First Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients., Cell 1990  
Most Recent Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations., Elife 2019            
All View All Papers 15 paper(s) referencing OMIMs 16 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 23 terms 26 terms 7 terms
PANTHER cftr
KEGG Pathways K05031 K05031
KOG [Q] Multidrug/pheromone exporter, ABC superfamily
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks cftr
Clones Horizon Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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