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Summary Expression Gene Literature (307) GO Terms (33) Nucleotides (49) Proteins (22) Interactants (337) Wiki
XB-GENEPAGE-853971

Gene Symbol: cftr

Gene Name: cystic fibrosis transmembrane conductance regulator

Synonyms: xcftr , mrp7 , abc35 , abcc7 , cftr/mrp , tnr-cftr , cftr-a , cftr-b ( Add Xenopus synonyms , Nomenclature history )

Gene Function: ABC transporter

Protein Function :
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Chan...[+]

Interactants: Loading ...
Disease Ontology: cystic fibrosis

OMIM Diseases: PANCREATITIS, HEREDITARY; PCTT [+]

 
Xenbase Gene ID XB-GENE-853972 XB-GENE-866530 XB-GENE-6466536
Gene Symbol cftr cftr.L cftr.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide NCBI Nucleotide
Protein TrEMBL NCBI Protein TrEMBL Swiss-Prot Swiss-Prot TrEMBL Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine cftr cftr.L cftr.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards CFTR OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Cftr MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR cftr ZFIN Ensembl
chicken
GEISHA CFTR Ensembl
fruit fly
worm
WORMBASE
Publications
First Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients., Cell 1990  
Most Recent Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations., Elife 2019  
All View All Papers 15 paper(s) referencing OMIMs 16 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 18 terms 5 terms 25 terms
PANTHER cftr
KEGG Pathways K05031 K05031
KOG [Q] Multidrug/pheromone exporter, ABC superfamily
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon Dharmacon
Affymetrix 1.0 Str.50540.1.S1_at [+] Xl.21454.1.S1_at [+]
Affymetrix 2.0 Xl2.21454.1.A1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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