Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (37) GO Terms (0) Nucleotides (48) Proteins (3) Interactants (428) Wiki
XB-GENEPAGE-855943

Gene Symbol: h2axl

Gene Name: H2A.X variant histone-like

Synonyms: h2a/x , h2a.x , h2afxl ( Add synonyms , Nomenclature history )

Gene Function: chromatin structure

Protein Function :
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central ro...[+]

Interactants: Loading ...
Disease Ontology:

OMIM Diseases:

 
Xenbase Gene ID XB-GENE-22066268 XB-GENE-17331618 XB-GENE-6493983
Gene Symbol h2axl h2axl.L h2ax.lS
Chromosome Scaffold82179
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence
CDS
Entrez Gene
mRNA RefSeq
Protein RefSeq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine h2axl h2axl.L h2ax.lS
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards H2AX OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR H2afx MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR h2ax ZFIN Ensembl
chicken
GEISHA H2AFX Ensembl
fruit fly
worm
WORMBASE
Publications
First DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: involvement of protein phosphorylation in nucleosome spacing., EMBO J 1991  
Most Recent Nuclear ARP2/3 drives DNA break clustering for homology-directed repair., Nature 2018                                
All View All Papers 2 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 0 term terms
PANTHER h2axl
KEGG Pathways K11251
KOG
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Dharmacon Dharmacon
Antibody H2afx Ab1 , H2afx Ab2 H2afx Ab1 , H2afx Ab2 , Hist1h4a Ab4
ORF h2afx.L ORF1
Affymetrix 1.0 Xl.19141.1.S1_x_at [+]
Affymetrix 2.0 Xl2.19141.1.S1_at [+]

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.4


Major funding for Xenbase is provided by grant P41 HD064556