Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (10) GO Terms (14) Nucleotides (347) Proteins (19) Interactants (128) Wiki
XB-GENEPAGE- 868336

Gene Symbol: eif6

Gene Name: eukaryotic translation initiation factor 6

Synonyms: itgb4bp , p27BBP , p27(BBP)
Add Xenopus synonyms , Nomenclature history


Gene Function: translational initiation

Protein Function :
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.


Interactants: Loading ...

Disease Ontology:
  

OMIM Diseases:
  
 

Xenbase Gene ID XB-GENE-868337 XB-GENE-17338943 XB-GENE-868348
Gene Symbol eif6 eif6.L eif6.S
Chromosome Chr10 chr9_10L chr9_10S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq TrEMBL TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.5852 [+] Xl.5851
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 4 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine eif6 eif6.L eif6.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards EIF6 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Eif6 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR eif6 ZFIN Ensembl
chicken
GEISHA EIF6 Ensembl
fruit fly
FLYBASE eIF6 Ensembl
worm
WORMBASE
Publications
First: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. [J Biol Chem 1997]
Most recent: Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development. [Dev Biol 2017]
View All Papers 2 paper(s) referencing morpholinos
Functional Ontologies tropicalis laevis.L laevis.S
GO 14 terms 0 term 7 terms
PANTHER eif6
KEGG Pathways K03264 K03264
KOG [J] Translation initiation factor 6 (eIF-6)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Eif6 Ab1 Eif6 Ab1
Morpholino eif6 MO1 eif6 MO1 eif6 MO1
ORF eif6 ORF1 eif6.S ORF1
Affymetrix 1.0 Str.22166.2.S1_a_at [+] Xl.5851.1.S1_at
Affymetrix 2.0 Xl2.5851.1.S1_at

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.1
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556