Gene Symbol: nkx3-2 Gene Name: NK3 homeobox 2 Synonyms: Xbap, bapx1, bagpipe homeobox homolog 1, nkx3.2 Add Xenopus synonyms Gene Function: homeodomain transcription factor Interactants: nkx3-1(10) , hoxa2(4) , bapx(3) , slc12a3(3) , bmp4(2) , gsc(2) , hand2(2) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		NCBI Nucleotide >XM_002940741|PREDICTED: Xenopus (Silurana) tropicalis homeobox protein Nkx-3.2-like (LOC100497965), mRNA ATGTTCAGAGGCCCACTGGATACCCCCTGGGCAGCCGATGTTCCCCCCAGTGGCCCACACAGGATCAAGGCTGGCCGCTCTGCCCTGCTAGTGCCTATCTTGGGATCCATTTGGGGAGCTTGGTGCCCAGAGCCAGGAGCCACCCGGTGCCGGACACTGGATCCGATGGCAGCTGTGCGAAGCTCGGGCAGCCTGACCCCATTCTCCATACAGGCTATTCTGAACAGGAAAGAGGAGCGTGCCCGCACCTTCCCCAGGCTGGGCTCCGCAGTCTCTCCCGCCTGTTGCTGGAGGATCTTTGGGGAGACAGAGGCAGATGGACTGGGCTCCCTTTGCGGAGGGACACCTGGGACAGGAGCCGGAGGAGAGCCAGCCGGGTGGGATTCAGACTCTGCCCTGAGTGAGGAGGGAGAACTGGGGAGGCCGGGGGACACCGGGGAGAGGAAGAAGCAGAGGCCGCTGGAGGCCAGAACCAAGGGGGAGGATGAGGAGGAAACCCCAGGCTGCAGCGACTGTGAGATAGGAGCAGGCGTCCCAGATCCCAGCCCCCCAGATGAGGACCCCAAGTGTGAGCAGCTGATGCTGGAACCCCCCAAGCAGAGAAAGAAGCGCTCCCGGGCTGCATTCTCTCATGCCCAGGTTTTCGAGCTAGAGAGACGCTTCAACCACCAGCGATACCTGTCCGGGCCCGAGCGGGCCGACCTGGCTGCCTCCCTTAAGCTAACAGAAACCCAGGTGAAGATATGGTTCCAAAACAGGCGCTACAAGACCAAGCGCAGGCAGATGGCCGCTGACCTTCTTGCTGCAGCCCCTGCAGCAAAGAAAGTAGCTGTGAAAGTGCTGGTGAGGGACGATCAGAGACAATACCAGCCTGGGGAAGTCCTGCGCCCCTCACTGCTTCCCCTTCAGACCCCCTACTTCTACCCTTATTACTGCGCCCTGCCTGGCTGGACACTCTCAGCAGCTGCCTGCAGTGGGGGGACTCCATAA	Refseq >NM_001085813|Xenopus laevis NK3 homeobox 2 (nkx3-2), mRNA ATGTTCAGAGGCCCTCTGGATACCCCCTGGGCAGCAGATGTTTCCCCCAGTGGCCCACGCGGGATCAAGGCTGGACGCTCTGCCCTGCTAGTGCCCATCTTGGGATCCATTTGGGGAGCTTGGCGCCCAGAGCCAGGAGCCACCCGGTACCGGACACTGGATCCAATGGCAGCTGTGCGAAGTTCCAGCAGGCTGACTCCATTCTCTATCCAGGCTATTCTGAACAGGAAAGAGGAGCGTGCCCACACGTTCCCCAGGCTGGCCACTGCAGTCTCACCCGCCTGTTGCTGGAGGATCTTTGGGGAGAGTGAAGCAGAAGGACTGGGCTCCCCATGTGGAGGGGCCCCTGGGGCAGGAGCCGGGGGAGAGCCATCCGGGTGGGACTCGGATTCAGCCCTCAGTGAGGAGGGAGAACTGGGAAGGCCGGGGGATATCGGGGAGAGGAAGAAGCAGAGGCCGCTGGAGGCCAGAGCCAAGGGGGAGGATGAGGAGGAAACCCCAGGCTGCAGCGACTGCGAGATAGGAGCCAGTGTCCCAGATCCCAGCCCTCCAGATGAGGATCCCAAGTGTGAGCAGCTGATGCTAGAGCCCCCCAAGCAGAGAAAGAAGCGCTCCCGGGCTGCATTCTCCCATGCCCAGGTCTTTGAGCTGGAGAGACGCTTCAACCACCAGCGATACTTGTCTGGCCCTGAGCGAGCTGACCTGGCTGCCTCCCTTAAACTAACAGAGACCCAGGTGAAGATATGGTTCCAGAACAGGCGCTACAAGACCAAGCGCAGGCAGATGGCTACCGACCTTCTTGCTGCAGCCCCTGCAGCAAAGAAAGTTGCTGTGAAAGTGCTGGTGAGGGACGATCAGAGACAGTACCATCCTGGGGAGGTCCTTCACCCTTCACTGCTTCCCCTTCAGGCCCCTTATTTCTACCCTTATTATTGTGCCCTGCCTGGCTGGACGCTCTCCGCAGCTGCCTGCAGTAGGGGGACGCCATAA
Protein		NCBI Protein >XP_002940787|PREDICTED: homeobox protein Nkx-3.2-like [Xenopus (Silurana) tropicalis] MFRGPLDTPWAADVPPSGPHRIKAGRSALLVPILGSIWGAWCPEPGATRCRTLDPMAAVRSSGSLTPFSIQAILNRKEERARTFPRLGSAVSPACCWRIFGETEADGLGSLCGGTPGTGAGGEPAGWDSDSALSEEGELGRPGDTGERKKQRPLEARTKGEDEEETPGCSDCEIGAGVPDPSPPDEDPKCEQLMLEPPKQRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLAAAPAAKKVAVKVLVRDDQRQYQPGEVLRPSLLPLQTPYFYPYYCALPGWTLSAAACSGGTP	Refseq >NP_001079282|homeobox protein Nkx-3.2 [Xenopus laevis] MFRGPLDTPWAADVSPSGPRGIKAGRSALLVPILGSIWGAWRPEPGATRYRTLDPMAAVRSSSRLTPFSIQAILNRKEERAHTFPRLATAVSPACCWRIFGESEAEGLGSPCGGAPGAGAGGEPSGWDSDSALSEEGELGRPGDIGERKKQRPLEARAKGEDEEETPGCSDCEIGASVPDPSPPDEDPKCEQLMLEPPKQRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMATDLLAAAPAAKKVAVKVLVRDDQRQYHPGEVLHPSLLPLQAPYFYPYYCALPGWTLSAAACSRGTP UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene			Xl.226
Unigene EST Profile			EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	NKX3-2
mouse		MGI	Nkx3-2	All(14) Targeted, knock Out(3) Targeted, other(5)
zebrafish		ZFIN	nkx3.2

Publications
First:		Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle. [Dev Biol 1997]
Most recent:		Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. [Development 2011]
		View All Papers 3 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		DNA binding transcription factor activity
Biological:		regulation of transcription, DNA-dependent
Cellular Component:		nucleus
EC:
KOG:		[K] Transcription factor tinman/NKX2-3, contains HOX domain

Reagents		tropicalis	laevis
Clones			open biosystems
			geneservice/RZPD imagenes
Affymetrix 1.0		StrEns.8486.1.S1_at	Xl.226.1.S1_at
Affymetrix 2.0			Xl2.226.1.S1_at

Symbol legend[+]

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