Gene Symbol: dkk3 Gene Name: dickkopf WNT signaling pathway inhibitor 3 Synonyms: dkk-3 Add Xenopus synonyms Gene Function: secreted protein, negative regulator of Wnt receptor signaling pathway Interactants: dkk1(7) , dkk2(4) , kremen1(2) , nodal(2) , cdh1(1) , ctnnb1(1) , dvl1(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001123476|Xenopus (Silurana) tropicalis dickkopf 3 (dkk3), mRNA GGCGGAGGAAGTCTTGGCTCACCGCTTACCGGGATGGGCCCAATTACCTAATAATCATAACGAGTCCGTCACAGAGATGGAGATGGGAAATGAAACGATCCACTCGCAGAAGGAAATGACTAAGAATACAGATAATCACACAGGATCCACATTGTACTCTGAGACTGTAATAACTTCACTGAAGAACAACAGCAAGAGGCATCAAGAGTGCATTGTCGACGAGGACTGTAAATCTGGGAATTACTGTTACTTTGCAGATTCCGAATACAAATGTCTCCCGTGTAAAGCGACGGAGCCGTGCACGAGGGACGGCGAATGCTGCGAGGGGCTCTGTGTTTGGGGTCAGTGCGCCCACGTTACTAAGGGAGAAGGGGGGACCATCTGCGAGAGCCAAGAGGACTGTAACCCCGGATTCTGCTGCGCAGTTCATTCAGATCTCCTGTTCCCCGTTTGCACCCCCCTGCCAGGGGAAGGGGAACCCTGCTTGGACCCTTCCAACAAACTCCTGGACATAATGAACTGGGACGTACAGCCGGCCGGAGTGCTGGGCCGGTGCCCCTGCTCCCAAGGACTAGTGTGCCAGCCTCAGAGTCATGCCTTGGTATCCACGTGCCAAGAGCCTTCACCCGACGACAGCAAAAGATCTGATTTGGAGGTGCCCGAGGTGATCCCCCCATTCATAGGCATAATGCCCCAGGAGGGGCAGTACTATGAAGATGGAACTCAACTGTCGGATGGACCGTATGCCAGCCCTTCAGAGGAGAGTCGCAGCTTGGAATCGCGCTATGGAGATCCGTTACTGGCCGCGGCCAAGAGAGTCAGCGTGGATGTCCCAGAGGAGGTGCTGCCATTCGTTGGCATCATGGAAGAGCGAGATTACGAGGACAGTGACGTAGTGCCAACATCAGACAGCGTGCCAACATCAGACGGAGTGGACGCCGGCCCATTAGAGGAAACATACGAGACAGAACCAGGGTTGGTTGAGAAGAGTCCATTTGATGATTATAAATAAGACCATTAACTCGAATCCAGACGCCCAACGACCTCATCAGTGGCCAATTTGACCTATATCGCCTATCGATTCGGTTGCCTTAGGACTGGATAATGGGTGGGTAATGTGGTTGGCTGGTAAATGCATAGAGACTGGTGTTACCACAATACTAGAACTAAGCGACCACTCAAGACCCGGTGACTGTCTAGGACACTCACTGGGCAAGGGGTTGAAGTTGATGGACAGTTGCCTTTTTCATAGCTTGCACCTCCATCTAATCGGACACACGAACCAGGTCATAGCGCCGTAACCCCCAGCAACCAGTCACTGTCTACGTTGCACTTCAAGGTTAATGGCCGACTGGCTGCTCTAGGTAACCGCACTCATTCTGGGTCAGAACCTGGTTTAGCCAGCAGGATTAGGAACCAGATTCTGTAACCTCGGAACACTAGCCCTAAACAGTAGCCATTTTAGCACCTAAACTAATGGGATGGGGATTGTCATCCACCAAGGCCATATTGCTTGCTGCATCACGCTTAATGACCACTAGATGGAGTATAGACCACGAGTCTATGTAGAACAGGGGTCCTCAAACTTCTTAAGCAAGGGTCCCTCAGACTGGGCTGGACCCAGCTCCCCCCCCTCCCACTCAATCCTCTCTCAGCCAGTGCCGTCCGTCCTCCCTCTCAGCTCCCCGCTGAGTCCTCTCTCTCCGCTGCCAGGGGTGAGGACGCAGCGGGGGCCGGGTAAATTAACCTGGGGGGCTGGATCCGGCCCGCGGGCCTTAGTTTGAGGATCCCTGATGTAGAACGTCTCAGCCGAGGCAAGTAATATGGCTCCCATTGTAGCAATCACCCTGTAAATGGGCAAATGCATGACGCTGCCGTTGGATGTGAACCGGCCAGCAGGGGGCGACTCCAACTGGCGATCCTTTCAAGCAAAGGCGTCACATCCAACGGGAAAAGATTCTGAGCAACTTCCCCAGTCGTAATGGGGACGTTGCCCGGTTTGGCATCACCATAGAGGGAATGATATATTTATGTACAAGCAGAATGGCAGCTTCTTGGTCTTCACCGATGTTCCAGAACCGTACGCTGTATTGCTTCAGAACTTTCTCTCTGTTGGACACTTGCAATAATAAAGCGAATGTCAATTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001127818|Xenopus laevis dickkopf 3 (dkk3), mRNA CGGAGTCCTCGGCTGCGCATTATTCTCTGTCCTCCTCCCGAGACCCGGGTCTCTCCTCTGCAGGTCTGATCCTGGGCACGACTGGCACTAACTCTGTGTCTCTGCTCTGCCCACACCATGCCCACCTGCCTGCTCCTCATTCTGCCCCTGCTCTTCTTGGGCACCGTGACCCCTTCCCCAACCAGGAGCCCCTCAGAGAGTGAAGAATTCCTGGAGGCTGGTGGTGCCTCCCAAATGGATCCTATGTTCAGCTTTACAGAGGAGGAGGAGAGCCTGAATGACATGTTCAGGGAAGTGGAAGAGTTAATGGAGGACACTCAGTCTAAGCTGCAGAATGCAGTCAAAGAGATGGAGGCAGAGGAGGCTCACGGGTTACCAGGATGGGCCCAGCTACCTCCTAATTATCATAATGACTCCATCGTGGAGACGGAGGTTGGAAATGAAACCATCAGCATGCAGAAAGAAATCATTAAGAACACGGATAATCGCACAGGTTCCACGTTGTACTCACAGACTGTTATCACTTCTGTGAAGAGTAAAGAGAAACAGCAGCAAGAGTGCATTGTTGACGAGGACTGTAAAGCTGGGAATTACTGTCATTTTGGAGATTCAGAATACAGATGTCTCCTTTGCAAAGTGATGAAGCCGTGCACAAGGGACGGGGAATGCTGCGAGGGTCTCTGTGTTTGGGGTCAGTGCGCCAATGTTTTGAAAGGAGAGGGGGGAACCATCTGTGAGAGCCAAGAGGATTGCAACCCCGGATTCTGCTGCTCAGTTCACTCAAATCTCCTGTTCCCTGTTTGCACCCCTCTGCCAGTTAAAGGGGAACCTTGCTTCGACCCATCCAATAAATTCGTAGACATACTGAACTGGGACGTGCAGCCTGCCGGAGTTTTGGGCCGGTGCCCCTGCTCCCTCGGACTAGTGTGCCAGCCTCTTTCTCTCGACAACTTCCTTGACTGCTTATTGGTCGGACTGGTGAGAAAATGACCAGGTGGTGCTATGGAGAAAAGACCACATGGCTATGTAGCATGTCTCAGCTGAAGCAAGCAATAAGGCAAAACTGTGAGGGTTTCTGCTCATCCCTCTGCACCAACGTTCGAGAACCTTACATTGTATTATTTCTCTCTATGGGACACATGCAATAAAAGCATATCAATTAAAAAAAAAAAAAAA
Protein		Refseq >NP_001116948|dickkopf 3 [Xenopus (Silurana) tropicalis] MEMGNETIHSQKEMTKNTDNHTGSTLYSETVITSLKNNSKRHQECIVDEDCKSGNYCYFADSEYKCLPCKATEPCTRDGECCEGLCVWGQCAHVTKGEGGTICESQEDCNPGFCCAVHSDLLFPVCTPLPGEGEPCLDPSNKLLDIMNWDVQPAGVLGRCPCSQGLVCQPQSHALVSTCQEPSPDDSKRSDLEVPEVIPPFIGIMPQEGQYYEDGTQLSDGPYASPSEESRSLESRYGDPLLAAAKRVSVDVPEEVLPFVGIMEERDYEDSDVVPTSDSVPTSDGVDAGPLEETYETEPGLVEKSPFDDYK	Refseq >NP_001121290|dickkopf 3 precursor [Xenopus laevis] MPTCLLLILPLLFLGTVTPSPTRSPSESEEFLEAGGASQMDPMFSFTEEEESLNDMFREVEELMEDTQSKLQNAVKEMEAEEAHGLPGWAQLPPNYHNDSIVETEVGNETISMQKEIIKNTDNRTGSTLYSQTVITSVKSKEKQQQECIVDEDCKAGNYCHFGDSEYRCLLCKVMKPCTRDGECCEGLCVWGQCANVLKGEGGTICESQEDCNPGFCCSVHSNLLFPVCTPLPVKGEPCFDPSNKFVDILNWDVQPAGVLGRCPCSLGLVCQPLSLDNFLDCLLVGLVRK

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.21927 [+] Str.62993	Xl.70054
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	DKK3
mouse		MGI	Dkk3	All(4) Targeted, knock Out(2) Targeted, other(2)
zebrafish		ZFIN	dkk3 dkk3b

Publications
First:		Dickkopf genes are co-ordinately expressed in mesodermal lineages. [Mech Dev 1999]
Most recent:		Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus. [Evol Dev 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:
Biological:		multicellular organismal development negative regulation of Wnt receptor signaling pathway
Cellular Component:		extracellular region
EC:
KOG:		[T] Proteins containing Ca2+-binding EGF-like domains

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.21927.1.S1_at
Affymetrix 2.0			Xl2.52883.1.S1_at

Symbol legend[+]

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