Gene Symbol: acan Gene Name: aggrecan Synonyms: aggrecan, agc1, xagc1, sedk, agcan, cspg1, msk16, cspgcp Add Xenopus synonyms Gene Function: proteoglycan core protein Interactants: cd44(2) , sox9(2) , axin2(1) , bcan(1) , bmp7.1(1) , col2a1(1) , dkk1(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene
mRNA		NCBI Nucleotide >XM_002932251|PREDICTED: Xenopus (Silurana) tropicalis aggrecan core protein-like (LOC100491091), partial mRNA TGGCTGGTACAGTATGTTCAACATTTATTAATACAGCATTTATAGGCATATTCTTTTTCAAGGAGAACTAAACTTCTAAACTTAGTAAACTATGACCACTTTACTATTAGTGTTCGTTTGCTTGCGGGTCATCGCTGCAGCGATATCCACCATCACAACGCACTGAGTGTGATTATACCTGTAGAAGCTCCACTGAAAGTCCAGCTTGGACATTCCCTTACCATCCCTTGTTTCTTCATAAATGCTTTGGAAGATGTGACTGTGGCTCCCTCAACAGCACCCTTAACACCAAGGATCAAGTGGAGCAAACATGTCAAAGGAAAGGAAACCGTCCTGCTGGTAGCCACAGATGGACATGTTCGTGTAAATGACATCTACCAAGGCCGTGTCTCTATGCCCACCTACCCACTTGCCCCTACAGATGTCAGCCTGGAAATTTCCAACATACTGTCTAATGATTCAGGAATCTACCGCTGTGAAGTGATGCATGGGATAGAAGACAGCCAAGCTACAGTAGAGGTTAATGTGAAAGGTGTCGTTTTCCACTACAGAGCAATCTCGACCAGATATACTTTGGACTTTGAAAATGCCAAAAAAGCCTGCATACAAAACAGTGCCACCATTGCCACCCCCGAGCAGCTCCAGGCAGCATATGATGATGGTTACCACCAATGTGATGCTGGGTGGCTTTCCGACCAGACCGTTCGTTATCCAATTCATAATCCACGTGAAGCCTGCTACGGAGACAAGGACATGTTTCCAGGAGTGAGAACATATGGAGTTCGCGAAACAGATGAAACATATGATGTGTATTGCTATGTTGAGGATATGCAGGGTGAAGTGTTTTATGCAACATCTCCTGAAAAGTTCACCTTTGATGAAGCAGAAAAGCAATGTAAGAGCCTTGGTGCCAGATTGGCCACAACTGGAGAGCTCTATGTGGCATGGAAAAGTGGAATGGATATGTGCAGTGCGGGTTGGTTGGGAGACCGCAGTGTTAGGTACCCCATATCCTTTGCTCGGCCAAACTGTGGTGGAAATTTAGTAGGCGTAAGAACAGTTTATCTCCACCCCACCAACCAGACTGGATATCCTAATCCACTATCTCGGTATGATGCTATCTGCTACAAAGCTGGACCAGATGAGGAAATCACTATTCAAACCATTACACAGCCAAGTTTAGAGATCATCCTTCCCCGTAATGAGACAGAAGAGGAGGCTCGTGGCAGTATTGCTTCTCTTGAACCAACAGACTTTACCCTTACACCTACTGATTTTGAGGAATTTTTCACAGCAACCCCTGAGCTTGTGCTAACAGAAGGGCAATTTGAAAATGTCACAGAAGAAGTATTTCCCCTTGAAAATATTACAGCATCACTCCAAACAGAAGCCCCTGGTACAGCAGATGTGACATTCTCTGAGGGTCCAGAGTTTAATGCAACAACATCTTTAGGAGAGCAAATAGTTCCTGCAACAGCTGCTCCTGCTGAAGCTGGGCCAGAAAAAGACATTTCTAAGACTGGTGTTGTCTTTCATTACCGAGCTGCTTCCAGTCGATATTCCCTTAACTTCACCGAGGCTAAACAGGCATGTCTGGACAACAATGCTATCATTGCAAGCCCTGCTCAGCTCCAGGCTGCCTATGAAGCTGGATTTGATCAATGTGATGCTGGATGGATATCAGACCAAACTGTCAGATACCCAATAGTCACTCCAAGAGAAAACTGTCATGGAGACAAGAATGGATTTCCTGGGGTTAGAAATTATGGAGTGGTAAACCCAAATGCACATTTTGATGTGTACTGCTACATTGATAAACTTCATGGAGAGGTGTTTTTTGCCACTCAACCAGACCAGTTTACTTTCCAAGAAGCAAAAGAATTTTGTGATGGACAAAATGCCTCATTGGCCTCCACTGGACAGCTCTATATGGCCTGGAGGTTGGGGTTGGACAAGTGTAGAGCAGGCTGGTTGTCAGATGGAAGTGTCCGCTACCCCGTTGTGACACCTCGCAGAGCCTGTGGAGGAGACGTACCTGGAGTGCGGACAGTCTACATTCATCCTAATCAAACAGGATTCCCTGATCCTCTGTCAAAATACCACGCCTTTTGTTTCCGAGAAGAGATTCCAGGTTTTCCATCAATTGAGGAGGAGCTTATTGTGCCTGAGGTAGTCCCAGAAGTAGAGAAATTACCTTCTGGAGAAGGACCAACTTCCGAAATTGAAACTGTGACTGAATTTGAAAATCAGACAGATATCTGGCTGGCAAATGTCACTGTAATTCCTACTATTGATTCATCAGTAACAGTCAGTCCTTCAGTTGTTCCAATTGTGAGCCCAGATCCAGAAGATATAAGTGGAGAGACATCAGCAATAGGCAGTGGAGTAAGTGGAGAACTATCTGGATTGCCATCTGGAGTATCTAGTGGAGATGTGTCTGGTGCTGATCTAAGTGGACAACCATCAGGAGCTGAAGAAAGTGGATTTCCATCTGGCACTGACATTTCTGGAGTGAGTGGACTGCCATCTGGTGACATATCTGGTGACATATCAGGTGAACCTGATATTAGTGGACTGCCATCTGGATTTCCTTCAGGAGTTGAAGACATATCAGGTCAAGGTTCTGGAGTTCCAGATATAAGTGGGTTGTCTTCTGTACCAATTGAAACAAGTGGTCTCCCTTCTGGAGAGCCATCTGGAGATGAGATAATTAGTGGTTCAGCTTCTGGAATTGAGATAATTAGTGGCCTTTTTTCTGGTACAGAAGATTTCAGTGGCATTGCCTCAGGCTTCCCAACAATTACACATGTAGATACAACTTGGGAAGAAGCTGTTACAAAACCAACAGAAACTGAACTAGAAGGAAAGGGAGAAATTGAATTAAGTGCATCAGGAATAGAATTAAGTGGAGATCTTTCTGGCTTAGAGCCCAGTGGAGAGGTCTCTGGATTTGACCTTAGTGGGGTTACTTCATCAGTAGTAGAAAGCAGTGGAGATCTCTCTGGAATTATTTCTAGTGGTGATATTAGTGGAGAGCCATCAGGTATAATTGATTTGAGTGGTGAAGTGTCAGGAGTAACTGATATTAGTGGAGATTTGTCAGGATTAAAGGATTTTAGTGGTGAGACATCAGGAATATTGGATTTTAGTGGTGAGCTATCTGGCCTAAGTGGAGAATCATCAGGAATTATTTCTGTAAGTGGTGGATTTTCTGGAGATATAGATTTTAGTGGGGAGATTTCTGGAGTAAGAGAGATTAGTGGGGAGCTTTCTGGAGTTCCTGACATCAGTGGCTCGGCCTCCGGTATCTTAGAGATACCATCAGGTGTTTTTCTTATTGACCAAGCTTTGACAGAACTCTCTCAGCCATCAACAAAAGAAGAGGAAGGAAAAGGGTCTGTTGGAATAAGTGGCTTTTATTCAGGAGATGTTGACAGCTCTGGAGACATATCTGGCATCTTGGATGTCAGTGGTGGACCTTCAGGTTTTATAGACATTAGTGGTTTTGTTTCAGGGGCTGTTCCTAGTGGTGATATAGATATTAGTGGTGTATCAGACATAAGTGGTGCAACATCTGGAGTTGAATATGTTAGTGGCTTACAATCTGGATTTGATGATCTAAGTGGAGTCCCTACTGTTTCTCATATTGATTTCACATTAAAAGAGCCACCAACTCAAGGTCCTGATACTCAAGAAGCAGGAGAAGGTCCATCAGTAATACTTGAGATCAGTGGAATATCTGGAGAATCTTTGCCATCAGGAACTCATGAAGGCAGTCTAGAAAGTTCAGGCATATATACATCAGGATTTTCTCAAGTCACACTTGTTACTGATGATACTGTAGAAGCCATCACAAAACCAGCAGTTTCACAAGAGCTAGGTGGTGTTACTTTTGCATACCCAATAGAAACATCAGCATCTGGTGATATTAGCACCGAGGCATCTGCAACTCATGAAACCAGTGGAAAACAAGAAACATCTCTAGAAGGAAGCACTGAACCAAGCTCTGGACAGCTGACATTTTTGCCACCAGAAATATCTGAAACATCAGAATCTGAAATAACTCATTCTCCTGAGGAAGCACAACAGGAAACAGAATTAGTTACTTCAGTTGAACTGGGTGAAGTAACAGATGAACCCACGATTGAAGCAGCCAGTCCTTCAAGTCTAATTGCAACTGAGTCTGAAGGAATAATTGGATCATGTGCTGATCAACCCTGCGGAGCTGGAACATGTACAGAAAAGGAAGGAAGAATATACTGTGCCTGCCTGCCAGGCTATGGTGGAGAACTTTGTAATATAGACATTGATGAGTGCCACTCAAGCCCCTGTGTGAATGGAGCTACCTGCGTTGATGGCATCGACTCATTCAAATGCTTATGCCTTCCCAGCTACGGAGGGGACCTATGTCAGATCGATCTAGAGGTGTGTGAGGATGGATGGACCAAGTTCCAGGGTCACTGCTACAAACACTTTTCAGAGAGAGAAACTTGGGTGGATGCAGAAAACGTCTGTCGGTATCACCAGTCCCATCTAGCGAGCATTCTCACACCTGAAGAGCAAGAATTTGTGAATGGTAACGCTCAGGACTATCAATGGATTGGGCTGAATGATAAGACAATTGAAAATGATTTCCGCTGGTCAGATGCAAACCCCTTGCAATATGAAAACTGGAGGCCAAACCAACCAGATAACTTCTTCACCACGGGAGAAGATTGTGTTGTTATGATCTGGCATGAACGTGGAGAATGGAATGATGTTCCCTGTAACTACCACCTGCCATTTACATGCAAAAAGGGAACAGTGGCTTGTGGTGATCCTCCAGCAGTGCAAAATGCCTACACACTAGGAAAAAAGAAAGCACGTTATGAAATCAGCTCCTTAGTGCGGTATCAATGTAACCAAGGCTACCTACAACGTCATGTTCCTATAATCCGATGTCTACCAACTGGGCACTGGGATGAGCCCAGGATACAGTGCATAGATCGTGTAAGTGTTATAGCTCCACTAGGGTCCAGAGTCCTGAGAAAAGCATATAAACAGTTGGATCTTTACCACAAAAAGTTGTGGCGTAAAGAACCCAACACACAATCCTAA
Protein		NCBI Protein >XP_002932297|PREDICTED: LOW QUALITY PROTEIN: aggrecan core protein-like, partial [Xenopus (Silurana) tropicalis] WLVQYVQHLLIQHLXAYSFSRRTKLLNLVNYDHFTISVRLLAGHRCSDIHHHNALSVIIPVEAPLKVQLGHSLTIPCFFINALEDVTVAPSTAPLTPRIKWSKHVKGKETVLLVATDGHVRVNDIYQGRVSMPTYPLAPTDVSLEISNILSNDSGIYRCEVMHGIEDSQATVEVNVKGVVFHYRAISTRYTLDFENAKKACIQNSATIATPEQLQAAYDDGYHQCDAGWLSDQTVRYPIHNPREACYGDKDMFPGVRTYGVRETDETYDVYCYVEDMQGEVFYATSPEKFTFDEAEKQCKSLGARLATTGELYVAWKSGMDMCSAGWLGDRSVRYPISFARPNCGGNLVGVRTVYLHPTNQTGYPNPLSRYDAICYKAGPDEEITIQTITQPSLEIILPRNETEEEARGSIASLEPTDFTLTPTDFEEFFTATPELVLTEGQFENVTEEVFPLENITASLQTEAPGTADVTFSEGPEFNATTSLGEQIVPATAAPAEAGPEKDISKTGVVFHYRAASSRYSLNFTEAKQACLDNNAIIASPAQLQAAYEAGFDQCDAGWISDQTVRYPIVTPRENCHGDKNGFPGVRNYGVVNPNAHFDVYCYIDKLHGEVFFATQPDQFTFQEAKEFCDGQNASLASTGQLYMAWRLGLDKCRAGWLSDGSVRYPVVTPRRACGGDVPGVRTVYIHPNQTGFPDPLSKYHAFCFREEIPGFPSIEEELIVPEVVPEVEKLPSGEGPTSEIETVTEFENQTDIWLANVTVIPTIDSSVTVSPSVVPIVSPDPEDISGETSAIGSGVSGELSGLPSGVSSGDVSGADLSGQPSGAEESGFPSGTDISGVSGLPSGDISGDISGEPDISGLPSGFPSGVEDISGQGSGVPDISGLSSVPIETSGLPSGEPSGDEIISGSASGIEIISGLFSGTEDFSGIASGFPTITHVDTTWEEAVTKPTETELEGKGEIELSASGIELSGDLSGLEPSGEVSGFDLSGVTSSVVESSGDLSGIISSGDISGEPSGIIDLSGEVSGVTDISGDLSGLKDFSGETSGILDFSGELSGLSGESSGIISVSGGFSGDIDFSGEISGVREISGELSGVPDISGSASGILEIPSGVFLIDQALTELSQPSTKEEEGKGSVGISGFYSGDVDSSGDISGILDVSGGPSGFIDISGFVSGAVPSGDIDISGVSDISGATSGVEYVSGLQSGFDDLSGVPTVSHIDFTLKEPPTQGPDTQEAGEGPSVILEISGISGESLPSGTHEGSLESSGIYTSGFSQVTLVTDDTVEAITKPAVSQELGGVTFAYPIETSASGDISTEASATHETSGKQETSLEGSTEPSSGQLTFLPPEISETSESEITHSPEEAQQETELVTSVELGEVTDEPTIEAASPSSLIATESEGIIGSCADQPCGAGTCTEKEGRIYCACLPGYGGELCNIDIDECHSSPCVNGATCVDGIDSFKCLCLPSYGGDLCQIDLEVCEDGWTKFQGHCYKHFSERETWVDAENVCRYHQSHLASILTPEEQEFVNGNAQDYQWIGLNDKTIENDFRWSDANPLQYENWRPNQPDNFFTTGEDCVVMIWHERGEWNDVPCNYHLPFTCKKGTVACGDPPAVQNAYTLGKKKARYEISSLVRYQCNQGYLQRHVPIIRCLPTGHWDEPRIQCIDRVSVIAPLGSRVLRKAYKQLDLYHKKLWRKEPNTQS

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.62654
Unigene EST Profile		EST Profile
GEO data			GEO
Images		4 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	ACAN	OMIM:608361
mouse		MGI	Acan	All(8) Targeted, other(5) Spontaneous(2) Chemically Induced(1)
zebrafish		ZFIN	acana

Publications
First:		The formation of human synovial joint cavities: a possible role for hyaluronan and CD44 in altered interzone cohesion. [J Anat 1994]
Most recent:		The protein kinase MLTK regulates chondrogenesis by inducing the transcription factor Sox6. [Development 2012]
		View All Papers 1 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		hyaluronic acid binding sugar binding
Biological:		cell adhesion
Cellular Component:
EC:
KOG:		[TV] C-type lectin

Reagents		tropicalis	laevis
Clones		open biosystems
		geneservice/RZPD imagenes
Affymetrix 1.0		StrJgi.428.1.S1_at [+] StrEns.721.1.S1_s_at
Affymetrix 2.0

Symbol legend[+]

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