plk1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (89)

Nucleotides (357)

Interactants (98)

XB-GENEPAGE-941539

Gene Symbol: plk1 Gene Name: polo-like kinase 1 Synonyms: PLK-1, Plx1, plk, polo-like kinase 1 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: cdk1(42) , cdc25c(30) , pold1(28) , ccnb1.2(23) , rasgrf1(17) , mapk1(14) , mos(8) View All

XB-GENE-941540

XB-GENE-941545

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_213679\|Xenopus (Silurana) tropicalis polo-like kinase 1 (plk1), mRNA CAGAAGGAGTAGGAGCTACACGGCTTCCCAGCAGCCTCGGATACTCTGCCACGTCTTGTCCCATTGCGCACCCCTCATCTGCCCAGCGCTTTCCCTTTCATCAGTAGCATCAAGCAGCTTGAGCCTTATCGCTGTCACACCGCACTATGGCTCAAGTAGCCGGTAAGAAACTGACTGTGGCCCCAGAGGCCGGTAAACCCCCGGGGATCCCCGGTTCCTCGTCATCCGTCAAAGAGATTCCAGAGATTCTGGTGGATCCCCGCACCCGGAGGCGATACCTGAGGGGGAGATTTCTGGGCAAAGGTGGGTTCGCTAAATGCTACGAGATCACCGACCTGGAGAGCCGGGAGGTATTTGCTGGGAAGATTGTGCCCAAGACCATGCTGCTCAAGCCCCACCAGAAGGACAAAATGACCATGGAGATCGCCATCCAGCGCAGTCTTGACCACCGGCATGTCGTGGGCTTCCATGGCTTCTTTGAGGACAATGACTTCGTGTATGTGGTACTTGAGCTGTGCCGACGGAGGTCTCTATTGGAGCTGCACAAGAGGAGGAAAGCTGTAACAGAGCCAGAAGCTCGCTACTATTTGAAACAGACCATTTTGGGGTGCCAGTATCTCCATAGCAACAGAGTCATTCACAGAGACCTCAAGCTTGGCAACTTGTTCCTTAATGATGAAATGGAGGTCAAAATAGGTGACTTTGGGCTGGCAACCAAAGTGGAATATGATGGCGAGCGCAAGAAAACCCTCTGTGGCACTCCAAACTACATTGCACCTGAAGTGTTGGGCAAGAAGGGCCACAGTTTTGAAGTGGACATATGGTCAATAGGATGCATCATGTACACGCTGCTGGTGGGAAAACCCCCCTTTGAAACATCATGCCTAAAAGAAACCTACATGAGGATTAAAAAGAATGAATACTCTGTCCCCAAGCACATTAACCCCATGGCGACAGCACTTATACAGAAGATGCTTCGTTCCGAACCAACCTCAAGGCCCACGATAGATGACTTGCTAAATGATGAGTTCTTTACTACTGGCTACATTCCTTCCCGGCTCCCCACAACCTGCTTAACTGTGCCCCCAAGGTTTTCCATTGCACCCAGCACTATTGATCAAAGCTTAAGGAAGCCACTTACTGCAATCAATAAAGGACAAGACTCTCCACTGGTGGAGAAGCAGTCGGTTCCTGCAAAGGAAGAAGAAATGCAGCAGCCGGAGTCCACAGAGCCTGCAGACTGTTACCTATCTGAGATGCTTCAGCAGCTGACTTGTGTGAATGCAGTCAAGCCTTCTGAGAGAGCGGTTATCCGCCAAGAGGAAGCAGAGGATCCAGCATCCGTCCCCATATTCTGGGTCAGCAAATGGGTGGACTACTCTGATAAATATGGATTAGGATACCAGCTGTGTGATAACAGTGTTGGGGTGCTCTTTAATGATTCAACGCGGTTGATAATGTACAATGACGGAGACAGCCTGCAGTACATTGAGAGGAATAATTCAGAGTCTTACCTCAACGTGCGCTCCTACCCTGCTGCTTTAACCAAAAAGATCACATTGCTCAAGTACTTCAGAAATTACATGAGTGAGCACCTACTGAAGGCCGGTGCAAACATAACACCCCGGGAGGGGGATGAACTGGCTCGTCTACCCTTCTTACGAACCTGGTTCAGGACACGCAGCGCCATCATCCTCCACCTGAGCAATGGGACTGTTCAGATAAACTTCTTCCAGGATCACACAAAGATAATCCTGTGCCCCCTTATGGCTGCTGTGTCCTACATTGATGAAAAGCGTGAGTTCCATACGTACAAGCTGAGCCTCATTCAAGAATTTGGCTGCTGCAAGGAGCTCGCCAGCCGTCTCCGCTACGCACGCACAATGGTGGAGAAACTACAGAGCTCCAAGTCCGGTGTTGCACATGTGAAGGCCTCTGCATAGCCGGCCTGGCAAACTGTGGACTCAGAAACCAGAAACTAGTCCATATTCTTAGGTTTCTGGAAGCACCAGACCTTGTTTCGGGGTCCGAGGAGCACTCGCCTTTTCAATTTTAAGCCGAAGCTGACATGTTCTAGGGTGAGATGGATCGCTAAGCTCGCCAAGACTGTACAGTACTCGCGTAATGTTTCCATAAATATATATCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001087319\|Xenopus laevis polo-like kinase 1 (plk1), mRNA GGGCCCCAGGGACTGAGCAGCAGAAGGAGTAGCAGCTACACGGCTTCCCTCAGCCTCGGACAACCTGCCACGTCCTGCCCCATCGATCTCCCCTGATCTGCCCAGCACTTCCCCATTCATCAGGCGCCTCAATACTCGAGCTTTAATAGCCGGCACCCCGCACTATGGCTCAAGTGGCCGGTAAGAAACTGACTGTGGCCCCAGAGGCCGCTAAACCCCCAGGAATTCCCGGGAGCTCCTCGGCCGTCAAAGAGATCCCAGAGATTCTAGTGGATCCCCGAACCCGGAGGCGATACCTGAGAGGTCGATTCCTGGGCAAAGGTGGATTCGCCAAGTGCTACGAGATCACCGACCTGGAGAGCCGGGAGGTATTTGCTGGGAAGATTGTGCCCAAGACCATGTTGCTCAAGCCCCACCAGAAGGATAAGATGACCATGGAGATCGCCATCCAGCGCAGCCTGGACCACCGGCATGTCGTGGGCTTCCATGGCTTCTTTGAGGACAATGACTTCGTGTATGTGGTACTGGAGCTGTGCAGGAGGAGGTCTCTGTTGGAGCTGCACAAGAGGAGAAAAGCGGTTACAGAGCCAGAAGCTCGCTACTATTTGAAACAGACCATTTCGGGATGTCAGTATCTCCATAGCAACCGAGTCATTCACAGAGACCTCAAGCTCGGAAACTTGTTCCTTAATGATGAAATGGAGGTCAAAATAGGTGACTTTGGGCTGGCAACCAAAGTGGAATATGATGGCGAGCGCAAAAAGACCCTCTGTGGCACTCCAAACTACATTGCACCTGAGGTGTTGGGCAAGAAGGGCCACAGTTTTGAAGTGGACATATGGTCAATAGGATGCATCATGTACACACTGCTGGTGGGGAAACCTCCCTTTGAGACATCATGCCTGAAAGAAACCTACATGAGAATTAAAAAGAATGAATACTCCATCCCCAAGCACATTAACCCTGTGGCAGCAGCACTTATACAGAAGATGCTCCGTTCTGACCCAACCTCAAGGCCCACAATAGACGACTTGCTGAATGACGAGTTCTTTACTTCTGGCTACATTCCTTCCCGGCTCCCCACAACCTGCTTAACTGTGCCCCCAAGGTTTTCCATTGCGCCCAGCACTATTGATCAAAGCTTAAGGAAGCCACTTACTGCAATTAATAAAGGGCAAGACTCTCCACTGGTTGAAAAGCAGGTGGCTCCTGCAAAGGAAGAGGAGATGCAGCAGCCGGAGTTCACGGAGCCTGCAGATTGTTACCTATCTGAGATGCTCCAGCAGCTGACATGTTTGAATGCAGTCAAGCCTTCTGAGAGAGCGCTTATCCGCCAAGAGGAAGCCGAGGATCCGGCATCCATTCCCATATTCTGGATCAGCAAATGGGTGGATTACTCGGACAAATACGGATTAGGATATCAGCTGTGTGATAACAGTGTAGGGGTGCTCTTCAATGACTCCACACGGTTGATAATGTACAATGATGGAGACAGCCTGCAGTACATTGAGCGGAACAATACAGAATCCTACCTCAACGTGCGCTCCTACCCTACTACCTTAACCAAAAAGATCACACTGCTGAAGTACTTCAGAAACTACATGAGTGAGCACCTATTGAAGGCCGGTGCCAACACGACTCCTCGGGAGGGTGATGAACTGGCTCGTCTCCCCTTCTTGCGCACCTGGTTCCGGACACGCAGTGCCATTATCCTTCACCTGAGCAATGGAACTGTTCAGATCAACTTCTTCCAGGATCACACCAAGATAATCCTGTGCCCCCTTATGGCTGCGGTGTCCTACATAGATGAAAAGCGTGAGTTCCGCACGTACAAGCTGAGCCTGATTCAAGAATTTGGCTGCTGCAAAGAGCTCGCAAGCCGTCTCCGGTACGCACGCACAATGGTGGAGAAACTTCAGAGCTCAAAGTCAGCCGTTGCACACGTAAAGGCCTCGGCATAGCCGGCCAAGCAAACTATGGACTCCCCAGAAACAAACCCATATTCTTGGGTTTCTGGAAGCACAAGACCTTGTTTCAAGTCCTAGGAGCACCCGTCTTTTTAATTTTAAGCCGAAGCTGACATGTTCTAGGGTGAGATGGTTCGTTAAGCTTGCCAAGACTGTACAGTACTCGCGTGACGTTTCCATAAAAATATATCTTAAGTGCCACTCGTTGCGTCTGGGTAATCATGGATATGTGATGTAGATACCTGCTGGGCTCTGTATGAACCTGTGTCCTCCTGTTTTTCTCTGTCAACGTTGTCTGGTTTTTAATGTAAAAATATAATCTTTAATACTTTTGTATATTATCAGATTAAAGTTCTTTGTATAGCCGTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAG
Protein		Refseq >NP_998844\|serine/threonine-protein kinase PLK1 [Xenopus (Silurana) tropicalis] MAQVAGKKLTVAPEAGKPPGIPGSSSSVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTILGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSVPKHINPMATALIQKMLRSEPTSRPTIDDLLNDEFFTTGYIPSRLPTTCLTVPPRFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQSVPAKEEEMQQPESTEPADCYLSEMLQQLTCVNAVKPSERAVIRQEEAEDPASVPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNSESYLNVRSYPAALTKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFHTYKLSLIQEFGCCKELASRLRYARTMVEKLQSSKSGVAHVKASA UniProtKB	Refseq >NP_001080788\|serine/threonine-protein kinase PLK1 [Xenopus laevis] MAQVAGKKLTVAPEAAKPPGIPGSSSAVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEARYYLKQTISGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSIPKHINPVAAALIQKMLRSDPTSRPTIDDLLNDEFFTSGYIPSRLPTTCLTVPPRFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQVAPAKEEEMQQPEFTEPADCYLSEMLQQLTCLNAVKPSERALIRQEEAEDPASIPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNTESYLNVRSYPTTLTKKITLLKYFRNYMSEHLLKAGANTTPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFRTYKLSLIQEFGCCKELASRLRYARTMVEKLQSSKSAVAHVKASA UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.26747	Xl.28141
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	PLK1
mouse		MGI	Plk1	All(3) Gene Trapped(1) Targeted, other(2)
zebrafish		ZFIN	plk1	4 Lines(s)

Publications
First:		Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. [Science 1996]
Most recent:		Dynamic Regulation of Emi2 by Emi2-Bound Cdk1/Plk1/CK1 and PP2A-B56 in Meiotic Arrest of Xenopus Eggs. [Dev Cell 2012]
		View All Papers

Functional Ontologies
GO: Molecular:		ATP binding cAMP-dependent protein kinase activity cAMP-dependent protein kinase regulator activity More[+] protein binding protein kinase CK2 activity protein kinase CK2 regulator activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:		cAMP-dependent protein kinase complex protein kinase CK2 complex
EC:		now divided into EC:2.7.11.1, EC:2.7.11.8, EC:2.7.11.9, EC:2.7.11.10, EC:2.7.11.11, EC:2.7.11.12, EC:2.7.11.13, EC:2.7.11.21, EC:2.7.11.22, EC:2.7.11.24, EC:2.7.11.25, EC:2.7.11.30 and EC:2.7.12.1
KOG:		[D] Polo-like serine/threonine protein kinase

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.26747.1.S1_at	Xl.4535.1.S1_at [+] Xl.4535.2.S1_a_at Xl.4535.2.S1_at
Affymetrix 2.0			Xl2.28141.2.S1_a_at [+] Xl2.28141.2.S1_at

Symbol legend[+]