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Summary Expression Gene Literature (34) GO Terms (12) Nucleotides (93) Proteins (23) Interactants (98) Wiki
XB-GENEPAGE- 943035

Gene Symbol: nbn

Gene Name: nibrin

Synonyms: nibrin , nbs , nbs1
Add Xenopus synonyms , Nomenclature history


Gene Function: Transcription initiation factor IIF, large subunit (RAP74)

Protein Function:
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand b...[+]


Interactants: Loading ...

OMIM Disease Associations: NIJMEGEN BREAKAGE SYNDROME
 
Xenbase Gene ID XB-GENE-943036 XB-GENE-943040 XB-GENE-17337690
Gene Symbol nbn nbn.L nbn.S
Chromosome Chr06 chr6L
Molecules tropicalis laevis.L laevis.S
Gene GBrowse 8.0 JBrowse 8.0 GBrowse 7.1 JBrowse 7.1 GBrowse 4.1 JGI Genome 4.1 Ensembl 4.1 GBrowse 9.1 JBrowse 9.1 GBrowse 7.2 JBrowse 7.2 GBrowse 6.0
Entrez Gene
Entrez Gene
mRNA NCBI Nucleotide Refseq
Protein NCBI Protein Refseq TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus   Metazome
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.23333 Xl.9528
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 14 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine nbn nbn.L nbn.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards NBN OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI Nbn MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN nbn ZFIN Ensembl
chicken
GEISHA NBN Ensembl
fruit fly
worm
WORMBASE
Publications
First: The cell nucleus in early bovine and caprine preimplantation embryos: fine structural cytochemistry and immunoelectron microscopy. [Eur J Cell Biol 1996]
Most recent: Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma. [Dis Model Mech 2015]
View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs
Functional Ontologies tropicalis laevis.L laevis.S
GO 0 term 12 terms 0 term
EC
PANTHER nbn
KEGG Pathways K10867
KOG [K] Transcription initiation factor IIF, large subunit (RAP74)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Nbn Ab1 Nbn Ab1
Affymetrix 1.0 Str.23333.1.S1_at Xl.9528.1.A1_at
Affymetrix 2.0 Xl2.9528.2.S1_a_at [+]

Symbol legend[+]

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