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Summary Expression Gene Literature (2) GO Terms (19) Nucleotides (138) Proteins (43) Interactants (184) Wiki
XB-GENEPAGE-943657
Gene Symbol:
optn

Gene Name:
optineurin

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
ER-Golgi vesicle tethering

Protein Function :
Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
primary open angle glaucoma

OMIM:
GLAUCOMA, PRIMARY OPEN ANGLE; POAG [+]

External Links:
 
Xenbase Gene ID XB-GENE-943658 XB-GENE-943661 XB-GENE-17335375
Gene Symbol optn optn.L optn.S
Chromosome Chr03 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100144665
496250
100036954
mRNA NCBI Nucleotide RefSeq RefSeq
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine optn optn.L optn.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards OPTN OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Optn MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Optn Ensembl
zebrafish
ZFIN, AGR optn ZFIN Ensembl
chicken
GEISHA OPTN Ensembl
fruit fly
worm
Publications
First The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy., PLoS Pathog 2015                  
Most Recent Identification of new regulators of embryonic patterning and morphogenesis in Xenopus gastrulae by RNA sequencing., Dev Biol 2017                      
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 8 terms 7 terms
PANTHER optn
KEGG Pathways K19946 K19946
KOG [U] ER-Golgi vesicle-tethering protein p115
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks optn
ORFs optn.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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