map2k6 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog

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Summary

Gene Literature (10)

Nucleotides (212)

Interactants (44)

XB-GENEPAGE-944182

Gene Symbol: map2k6 Gene Name: mitogen-activated protein kinase kinase 6 Synonyms: SAPKK3, MKK6, MEK6 Add Xenopus synonyms Gene Function: serine/threonine kinase Interactants: mapk1(10) , mapk14(8) , mapk12(3) , mapk8(3) , act3(2) , atf2(2) , creb1(2) View All

XB-GENE-944183

XB-GENE-944189

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001005653\|Xenopus (Silurana) tropicalis mitogen-activated protein kinase kinase 6 (map2k6), mRNA CCCTGGCCCATCATGTAGGTGCAGAGCCCGGGCTCTCGGCTGCAACTGCAAAGGGGATATCAGAGAGAGAGGGAAAAGGAAAGCGACATTGAGAAGGGGAGGGCTGTTTGGCCAGTTTGCATTTGCTACTTGCACTTGTGCAATTCCACAGATCCAGCCGAGCGAGGAGTCCTGCAGCAGCCCGATCCTGCATAAACTAGACTGGGAGCCTGCAGTTTGCATCTTTGTTGTACAACTAGAGAGAGAGAGAGGGGAGAGGCAAAGTCTTTTGTGCACCCCTCCCCCAGCCCAGCACAGGGGAGAGAGAGAGAGAGAGAGAATGGCTCAGCCGAGAGGCAAGAAGAAAAATCCTGGGCTGAAAATTCCAAAGGAGGCATTTGACCAGCCACAAGTCAGCTCTCCGACGCCACCACGGGACTTGGACTCCAAAGCCTGCATCCTCATAGGAGAAAAGAACTTTGAAGTCAAGGCCGATGACTTGGAACCAATAGAAGAGCTAGGCCGGGGAGCCTATGGTGTCGTGGAAAAGATGCGCCATGTTCCCAGTGAGCAGATAATGGCAGTGAAGCGCATCAGAGCAACTGTGAACAGCCAGGAACAGAAAAGGCTGCTGATGGACCTGGATATCTCTATGCGCACAGTGGACTGCCATTTTACTGTCACGTTTTATGGGGCCTTATTTAGAGAGGGGGATGTCTGGATCTGCATGGAGTTGATGGATACGTCACTGGATAAATTTTACAAGAATGTGATTGACAAAGGCCTGACCATCCCCGAGGACATACTAGGAAAAATAGCAGTTTCGATTGTTAGAGCATTAGAACATCTGCATAGTAAACTCTCAGTGATCCACAGAGATGTGAAACCCTCCAACGTACTGATAAACAAAGAAGGCCAGGTGAAGATGTGTGACTTTGGAATCAGCGGTTATCTTGTTGACTCTGTAGCCAAAACCATGGATGCTGGCTGCAAACCCTACATGGCTCCTGAAAGAATAAACCCAGAGCTGAACCAGAAAGGGTATAGTGTAAAATCGGACATTTGGAGCCTTGGAATAACATTGATTGAACTGGCCATTCTGCGGTTTCCATATGACTCCTGGGGGACCCCTTTCCAACAGCTAAAACAAGTGGTCGAAGAGCCCTCCCCACAGCTGCCTGCAGACAAGTTTTCTGCTGAGTTTGTTGACTTTACCTCAAAGTGCTTGAAGAAAAATTCCAAAGAGCGTCCAACTTATCCAGAGCTTATGCAACACCATTTCTTTGTGCTGCATGAATCCAAGAACACTGATGTGGCATCTTTCGTTAAACGCATCTTGGGAGATTAAGTATATGCAGTATAGCCGGTCTCACCTTCTCATGGACTTTTCCTCTGACAGGACACACGGAATGGCTTAAATTGGCTGTCCTACTTAATCAAGCACCAGTAGAAATGCCTCATGGGACTGGGAAAACTGGACTCAATAGTTCTTTCTAATGGCCACTCTTCGCTACGGAACGGTTTTTCCAGCATGGAAAGATGTCTAACCCCTATGCTGCCATAGGTACCCTTATGGCTGTACAGGTGTTACTATAGATGCCTCTTGCCAAAGGGTGTAACTTTGACTGCTGCCGTATGGGGTTTATATTTAGGTTTCCTATTCTTTTTGACCTTTTTGTATTGGTTCTAGGTGCTATTTTAGTTCCTCTTTAACATGGTTTCTTCTTTATTTTTTTCCTTCCTACTTTCATTTTGGAGATATTTATGTTCTGTATTCTGATTAGGTTTGGTTTTTATGAAAGGACGTGTGTGTGATATAAGAGGAGAACAGTGGCAAATATTTATAGGGTTTTGCTGGTGAGAGGGTGAAATCTTTGTGTCCGCTATTATTTAAGTTGTTTTTTTTTTTGTTTTGTTTCTGGAACTGCTAAAGAATTCTGGAATTTTTCTTTGGAATGAGAATAGGTATATGTGCGGAGATTATGACTTGGTCACACATGAATAAATAGTGTTGGCTTGTTGTTGATTACTGAGGGGCAGGCAGTTGTCCCCTCTCAGAAGGAATCCAGACATAGTCTACTGTGTTATCTGAAGCCTTAATAACCTTTAAAAGTGGAGATTTTTTCCTGTAGAATAATCTTGAGGTTCTGTAATAATGTTACGCCTGAAAGAGAAGAGAATTAAAATGATTTACCTCTCCTGTGGTGAGCAATCTTATTGACAGTTTGTGGTTACATGCAGCAGGCCCTTCTAGTTCTCCTACCTCCCTTCTTATTTCATATATCTTGCTACTTTGGATAATTATAGGGCGACATAGGGCCAACCAATCATTTTTTTTTGTCCACGCAGACTTTCACTGTAACCAGTAACATTTGAGGTTTCTGTTGAAGTCGAACTCTTCCCAGAGGTTGTCTTCCTCTTTGTCCTTTGCCCCTTATCTTTCTCATTTTTCCTGTTGGAGGATTTTGCTTGTGCTTTACTCTTTTTAAAGTATTTTACAGCATTTAGAAATTATATATATATTTTTTTTCTGTGTTTTATACCTCTTTTCCCCTGAGGGGTCTGCAACTGATTAGAACTTTTTCCCCTTTCTAGATCTACATGAGGGTGAATCCACCATAAAAACACCTGAGTAAATTGTGATTTCTAATAAATTACACACAGTTTTTTTTTTGTTTTGTTTTTTTTAATTTATAACCATTTTTTGTTGCTGCATGAGGCACCTGCAGGTCTTTGCAAGAGGTAAACCAGTCATGGTATCCATGACAAATAGAAATGTTTGTATTGTGCAGAGGTGAGTTTATTCAGGGCATCATTTTTTTCTGTTTAGTTCAAATTTGGCCATTGTATGTTGTATGACTTCGACAGCGGATACTGTGGGGTTATAATACTATGTATGTCCTTAATGAGCAAAACACAGAGAAAACTAGGAGTATATTTCCAATCCAGTGACATGTCTTGCATACCAATTATATTTTTTAATGTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001086478\|Xenopus laevis mitogen-activated protein kinase kinase 6 (map2k6), mRNA GCGTGCTGAGCTCCTGCCGTTCCAAGTTTGGAGCTTTTCTGCTGGCAGCCCTGGCCCATCATGTAGGTGCAGAGCTCGGCTGCAAGTGGGGATATCAGAGAGAGTGAGAGAAAAAAAAAGAACAGCGAGATTGAGAAGGGGGAGGGCGTTTTGTCCAGTTTGCATTTGCTACTTGCACTTGTGCAATTCCGCAGATCCAGCCGAGCGAGGAGTCCTGCAGCAGCCCGATCCTGCATGAACTAGACTGGCAGTTTGCATCTTTGTTGTACAACTAGAGAGAGAGGGGAGAGGCAAAGTCTTTTGTGCACCCCTCCCCCAGCCCAGCACAGGGGAGTGAGAAAGAATGGCTCAACCGAGAGGCAGGAAGAAAAATCCAGGGCTGAAAATTCCAAAGGAAGCATTTGACCAGCCGCATGCCAGCTCTCCGACGCCTCCACGGGACTTGGACTCTAAAGCCTGTATCCTCATAGGAGAAAAGAACTTTGAAGTTAAGGCTGATGACTTGGAACCAATAGAAGAACTGGGCCGGGGAGCCTATGGAGTCGTGGAGAAGATGCGCCATGTTCCCAGTGAGCAGATAATGGCAGTGAAGCGCATCAGAGCTACTGTGAACAGCCAAGAACAGAAAAGGCTGCTGATGGACCTGGATATCTCTATGCGCACAGTGGATTGCCATTTTACTGTCACATTTTATGGGGCTTTATTTAGAGAGGGGGATGTCTGGATCTGCATGGAGTTGATGGACACGTCACTGGATAAATTTTACAAGGATGTGATTGACAAAGGCCTGACCATCCCCGAGGACATACTAGGAAAAATAGCAGTTTCAATTGTTAAAGCATTAGAACATCTGCATAGCAAACTCTCCGTAATCCACAGAGATGTGAAACCCTCCAATGTACTGATCAACAAAGAAGGTCAGGTGAAGATGTGTGACTTTGGAATTAGTGGTTATCTCGTTGACTCTGTAGCCAAAACCATGGATGCCGGCTGCAAACCTTACATGGCTCCTGAAAGGATAAACCCAGAACTGAACCAGAAAGGATACAGTGTGAAATCTGACATTTGGAGCCTTGGAATCACATTGATTGAACTGGCCATTTTACGGTTTCCATATGACTCCTGGGGGACCCCCTTCCAACAGCTAAAACAGGTGGTCGAAGAGCCGTCCCCACAGCTGCCTGCAGACAAGTTTTCTGCTGAATTTGTTGACTTTACCTCAAAGTGCTTGAAGAAAAATTCCAAAGAGCGTCCAACATATCCAGAGCTTATGCAACACCCTTTCTTTGTGCTGCATGAATCCAAGAACACTGATGTGGCATCTTTCGTTAAACGTATCTTGGGAGACTAAATCTGCCATAAAGGCTGGTCTCACCTTCTCATGGACTTTTCCTCTGACAGGACATGGAATGGCTTAAAGTGGCTGTCCTACTTAATCAAGCACCAGTAGAAATGACTCATGGGACTGGGAAAACTGGACTCGATATTTCTTTCTAATGGCCATTCTTTGCTACAGAACGGTTTTTCCAGCATGGAAAGATTTCTAACCCCTATGCTGCCATAGGTGCCCTTATGGCTGTACAGGTGTTACTATAGATGCCTCTTACCAAATGGTGTAACTTTGACTGCTGCCGTATAGGGTTAATATTTAGGTTTCCTATTCTTTTAGACCTTTTGTATTGGTTCTAGGTGCTATTGTAGTTCCTCTTTAACATGGTTTCTTCTATATTTTTTCTTCCCTTCCTACTATTGTTTTGGAGATATTTATGTTCTGTATTCTGATTAGGTTTGGTTTTTATGAAAGGACGTGTGTGTGGTATAAAAGGAGAACCGTGGCAAATATTTATAGGGTTTTGCTGGTGAGAGGGTGAAATCTTTTGTGTCCTCTATTATTTAAGTTTTTTTTTTTTTTTGGTTTCTAAAATTTTTCTTTGGATCGAGAATAGGTATATGTGCAGAGATTATGACCTGGTCACACATGAATAAATAGAGTTGGCTTGTTGCTGATTACTGAAGGGCAGGCAGTTGTCCTCATCGTCTACTAGTGTTATCTGAAGCCTTAATAACAATCTTAAAAAGTCAAGATTTGTTTTTTCTGTAGAATAATCACGAGGATCTATAATGATGTTACACCTGAAAGAGAAGATAATTAAAACAATTTACCTCTCCTGTGGTGAGCAATCCTATTGACAGTTTGTAGTTACATAAAGCAGGCCCATCTGTCGCTCCTATCTCCCTTCTTATTTCAAACATCTTGCAACTTTGGTTAATAATAGGGTAATTTAGGGCCAACCAATCCTTTCCCTTGTCAGCACAGACTTTTGCTGTTACCAGTAACCTTTGAGGTTTCTATTGAAGTCAAACTCTTCCCAGAGGTTGTCTTCCTCTTTGTCCTTTGCCCCCTACTTTTCTAATTTTTCCTGTTGGAGGATTTTGCTTGTGCTTTACTCTTTTTACTTTGTATTTTACAGCATTTAGAAATTATATATATATTTTTTTTCTGTATTTTCTACATTTTTTTCCCTGAAGAGGTCTGCAACTGATTAGCCTTTCCCCCCTATATACATCTACATGAGGGTGAATCCATAAAAACACCTGAGTAATTTCCTTTTTTTTTTTTTTTTTTTTATTATTTATAACCATTTTTTTGCTGCGTGAGGCACCTGCAGGTCATTGCAAGAGGTAAACCAGTCATGGTATCCATGACCAATAGAAATGTTTGTATTGTGCAGAGGTGAGTTTATTCAGGGCATCTTTTTCTGTTTAGTCTAAATTTGGCCATTGTATGTTGTATGCCTTTTACAGGGTCAACAGCAGATACTGTGGGGTTATAATACTATTAGGGATGCACCAAATCCACTATTTTGGATTTGGCCAAATCCTTCGCGAAAGATTCGGCCGAATACCAATCCGAATCCTAATTTGCATATGCACATTAGGGGTGGGAAGGGGAAAACATTTTTTACTTCCTTGTTTTGTGACAAAAAGGCACACGGTTTCCCTCCCCATCCAATATTTGCCTATGCAAATAAGAATTCGGATTCGGTTCGGCCAGGTAGAAGGATTCGGATGAATCCGAATTCTGCTAAAAAAAAGTCCGAATCCCGAACCGAATCATGGATTCGGGGCATCCCTAAATACTAAGTATGTCCTTAATGTGCAAAACACAGAGAAAACTAGTATATTTCCAATCCAGTGATATGTCTTGCATACCAATTATATTTTTTAATGTCAAAAAAAAAAAAAAA
Protein		Refseq >NP_001005653\|mitogen-activated protein kinase kinase 6 [Xenopus (Silurana) tropicalis] MAQPRGKKKNPGLKIPKEAFDQPQVSSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKNVIDKGLTIPEDILGKIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSKCLKKNSKERPTYPELMQHHFFVLHESKNTDVASFVKRILGD	Refseq >NP_001079947\|mitogen-activated protein kinase kinase 6 [Xenopus laevis] MAQPRGRKKNPGLKIPKEAFDQPHASSPTPPRDLDSKACILIGEKNFEVKADDLEPIEELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCHFTVTFYGALFREGDVWICMELMDTSLDKFYKDVIDKGLTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINKEGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITLIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSKCLKKNSKERPTYPELMQHPFFVLHESKNTDVASFVKRILGD

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase

Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.65431 [+] Str.46284	Xl.29871
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	MAP2K6
mouse		MGI	Map2k6	All(3) Targeted, knock Out(3)
zebrafish		ZFIN	map2k6

Publications
First:		Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). [EMBO J 1997]
Most recent:		Neural ectoderm-secreted FGF initiates the expression of Nkx2.5 in cardiac progenitors via a p38 MAPK/CREB pathway. [Dev Biol 2009]
		View All Papers 2 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		3-phosphoinositide-dependent protein kinase activity AMP-activated protein kinase activity ATP binding More[+] DNA-dependent protein kinase activity G-protein coupled receptor kinase activity IkappaB kinase activity JUN kinase activity JUN kinase kinase activity JUN kinase kinase kinase activity Janus kinase activity MAP kinase 1 activity MAP kinase 2 activity MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP/ERK kinase kinase activity MP kinase activity NF-kappaB-inducing kinase activity SAP kinase activity atypical protein kinase C activity cGMP-dependent protein kinase activity calcium-dependent protein kinase C activity calmodulin-dependent protein kinase activity casein kinase I activity casein kinase activity cobinamide kinase activity cyclic nucleotide-dependent protein kinase activity cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein kinase activating kinase regulator activity cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity diacylglycerol-activated phospholipid-dependent protein kinase C activity elongation factor-2 kinase activity eukaryotic elongation factor-2 kinase activator activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic translation initiation factor 2alpha kinase activity galactosyltransferase-associated kinase activity glycogen synthase kinase 3 activity multifunctional calcium- and calmodulin-regulated protein kinase activity non-membrane spanning protein tyrosine kinase activity phenol kinase activity phosphatidylinositol phosphate kinase activity phosphofructokinase activity phosphoinositide 3-kinase activity phosphorylase kinase activity phosphorylase kinase regulator activity phosphotransferase activity, alcohol group as acceptor protein kinase C activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein serine/threonine kinase activity receptor signaling protein tyrosine kinase activity ribosomal protein S6 kinase activity transmembrane receptor protein kinase activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein tyrosine kinase activity
Biological:		protein amino acid phosphorylation
Cellular Component:
EC:		Phosphotransferases with an Alcohol Group as Acceptor
KOG:		[T] Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.44206.1.A1_at [+] Str.44206.1.A1_s_at Str.46284.1.A1_at Str.25571.1.S1_at
Affymetrix 2.0			Xl2.29871.1.S1_at

Symbol legend[+]