[provisional- machine annotated only] Gene Symbol: rpa1 [Predicted: Source is Human Entrez Gene] Gene Name: replication protein A1, 70kDa [Predicted: Source is Human Entrez Gene] Synonyms: rp-a, hssb, rf-a, repa1, rpa70, mst075, rpa Add Xenopus synonyms Gene Function: Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins Interactants: atr(13) , cdc45(10) , chek1(10) , antxr1(9) , cdk2(9) , wrn(7) , pcna(6) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001015732|Xenopus (Silurana) tropicalis replication protein A1, 70kDa (rpa1), mRNA CGCCAGTAGGTTGAGTGTTGGTAGAAGGCAAGCGGGCGGGTAAGAGTGTTGCGCACACAAGGAGCCTGTAGTGTGACTTGGCTGCACTCTTCTACCGGGGGAACAGCAGCATGGCACTTCCAGTCCTCAGCGAGGGGGCTATCTCGGCTATATTGGGGGGCGATTCTTCTTGCAAGCCAACTCTGCAAGTAATTAATATCCGCTCAATCAACACTGGGAATGGTCCTCCACGTTACCGCCTTTTAATGAGTGATGGCTTGAATACCCTTTCTTCTTTTATGTTGGCTACCCAGCTGAACTTCCTTGTGGATAACAATCTTCTTGCCACAAACTGTATATGTCAAGTGTCACGGTTTATTGTAAATAATCTGAAAGATGGAAGGAGAGTCATCATTGTGATGGAGATGGAAGTTCTGAAATCTGCTGATTTAGTTAAGGGGAAGATTGGCAATCCACATCCTTATAATGATGGGCAAGGACCACCACAGCCTGCTGCACCTGCTCCAGCTTCAGCCCCACCGCCTAGCAAACCACAGAACATTTCAGCTCCTCCTCCTCCATCAATGAACAGAGGAGCATCTAAATTGTTTGGGGGGGGAAGTGTTGTAAACACACCTGGGGGCTCTCAGTCCAAGGTAGTGCCTATTGCAAGTCTCAATCCTTACCAGTCCAAGTGGACTGTTCGTGCTAGAGTTACCAATAAAGGTCAGATCCGCACATGGAGCAACTCCCGAGGGGAAGGGAAGCTATTTTCAATTGAGATGGTGGATGAGAGTGGTGAGATCCGAGCTACAGCTTTCAATGAGCAAGCTGACAAGTTCTTTTCCCTTATTGAAGTCAACAAGGTGTATTACTTCTCCAAAGGCACACTAAAAATTGCTAACAAGCAGTACACCTCTGTGAAGAACGACTATGAGATGACTTTCAACAGTGAGACGTCTGTTATTCCCTGTGATGACTCTGCTGATGTCCCAATGGTGCAGTTTGAATTTGTACCCATTGGTGAATTAGAAAGCAAGAATAAAGATACTGTATTAGATATCATAGGGATATGCAAAAACGCTGAAGAGGTAACCAAGGTCACAATAAGATCTAACAACAGAGAAGTTTCTAAGAGAAACATTAATTTAATGGATTCATCTGGTAAAGTGGTCTCAACAACTCTGTGGGGTGAAGATGCAGATAAATTTGATGGATCCCGACAACCTGTTGTTGCAATCAAAGGAGCAAGGCTTTCCGACTTTGGAGGGCGATCACTTTCAGTCTTATCGTCTAGCACTGTAATGATCAATCCTGATATTCCTGAAGCATTCAAACTCCGTGCATGGTTCGACTCTGAGGGGCAAGTTGTAGAAGGAACATCTATCTCTGAATCTCGTGGTGGAACAGGAGGTGGAAACACAAATTGGAAGTCATTGTTAGAAGTGAAAACTGAAAACCTTGGGCATGGTGAAAAGGCAGATTATTTCACTAGCGTTGCTACAATTGTGTATCTTCGAAAGGAAAACTGTCTTTATCAGGCATGCCCTTCACAAGACTGCAACAAAAAGGTGATAGATCAACAGAACGGGCTTTTCCGCTGTGAAAAATGTGACAAAGAATTTCCAAACTACAAATATCGTCTCATCCTTTCAGCTAACATCGCAGACTTTGGGGAGAATCAGTGGATTACCTGCTTCCAAGAATCAGCAGAGAGTATTCTGGGCCAGAATGCAACTTATCTTGGTGAACTTAAGGAGAAGAACGAGCAAGCCTATGATGAGGTGTTTCAGAATGCCAACTTCCGTTCTTACACGTTTAGGATTCGAGTTAAGCTAGAGACATACAATGATGAATCTCGTATAAAGGCCACAGCAATGGATGTGAAGCCCGTTGACCACAAAGAATACTCTAGAAGGCTGATTATGAACATTAGGAAAATGGCAGCTCAAGGTGTCTGATTTGCCATAAAGACCGTGATAAATCACTTAAAAGATATGGGAACGAAAATAAAATGTTTCATGGATGGACCAATACTAAAGCACTGAAGCTTAAACTGCATCATCTTCAAAATGATATAACCATTAGCACTTGCTCCCCAGAGTGTCCAGCTAGACCAAGTGAGCCGGAATAGATATAAGCATACATTCTTTTCATTCTGCTTTCCTTAAAACTCTCATCAACAAAGCAAAGCGTTCTCTACTGCTCTCATGGATGAGAAAAGGCCCCCAGCAGAATCCCCAAGGGGGGGTGGTCATTTGCATTTGTCATTGCTTACTGTTTAATTCTGTATGTATCCCAGATGCAGAGGAGGTAATGGAAGAACTGGATTGGACATTTGTTTGCTTCATTTTAATTTTGAATGCATAATTTGTGAGTGCCCTTCCTTTTGTGCAAGTATGTAGTTACCTTTAAGGAAGGCTTCCTTTCTTTTGGCTTTAGGTGCCATGAGTAGTATATTGTTTGGGGACTCCCTGTCTTCCTGTAAAAGACCTGGGGCTCCCAACCTCCTCTGCAAGTTTCTGCATCAGCCGGATGGATGTGCCATACTGTTTGCTAACGCTTGGAATGACAATATGGAAGAATTATTAATCAAAGACCTATCTTTTCTATCTGAAGACTTTCCTTCGGGGTTTAATAGACTGAGTCAGATGGCCCTGATATTAATCAAAATTCTCTCTTCTGAGGAGCTCTGATAAGCATTGACTCTCTGCCCCCTGGGGAAATCTGGCCAACTACAAAGCTTTGCTTTATTTTTCATTTAAATTAATATTTTGCTTTCTTACTCTCCCCTTTTCTTGACAGTGTGTAATTGCCAAAGTTTGCCGTTTGTACATTTACTGCTTCTCCTACACTTAAACTACTTTGCTATTTTTTTTTTCTTTTCTCAATGACTGAATTAATCGCTGTAGTTATAATGCAAAGAAAGGGGTTTCCTTTTATCCCCTAAACAAAATTAAAAGAAAAAGTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAA	Refseq >NM_001088116|Xenopus laevis replication protein A1, 70kDa (rpa1), mRNA GAATTCCGGCGTCGTCGGTCCCAAAGTTCCTGTGCGTGGGATTTGGCGGCAGGTTGAGTGGAGGCGCGCGCGGGTAATACGCACAGAAGGAGTCGGTAGTGTGAGTTGGCCGCGGTCTTGTCCTGGGAAAACAACAAGCAGTATGGCACTTCCACAACTGAGCGAGGGCGCTATCTCGGCTATGTTGGGTGGCGATTCTTCTTGCAAGCCAACTCTGCAAGTGATTAATATCCGCCCAATCAACACTGGAAATGGCCCTCCACGTTACCGTCTCTTAATGAGCGATGGCCTGAATACCCTTTCATCTTTTATGTTGGCAACCCAGCTGAACTCCCTTGTGGATAACAATCTTCTTGCCACAAACTGTATTTGTCAGGTGTCACGGTTTATTGTAAATAATCTGAAAGATGGAAGGAGAGTCATCATTGTAATGGAGTTGGACGTTCTGAAATCTGCTGATTTGGTTATGGGAAAGATTGGCAATCCACAGCCTTACAATGATGGGCAACCGCAGCCTGCAGCACCTGCACCAGCATCTGCTCCTGCTCCAGCACCTAGCAAACTACAGAACAATTCAGCTCCTCCTCCTTCAATGAACAGAGGAACGTCTAAATTGTTTGGAGGGGGAAGTTTATTGAACACACCTGGGGGATCTCAGTCCAAGGTAGTGCCCATTGCAAGTCTCAATCCTTACCAGTCCAAGTGGACGGTTCGTGCTAGAGTTACCAATAAAGGTCAGATCCGCACGTGGAGCAACTCCCGAGGGGAAGGGAAGCTATTTTCAATTGAGATGGTGGATGAGAGTGGTGAGATCCGAGCTACAGCTTTCAATGAGCAAGCTGACAAGTTCTTTTCCATTATTGAAGTCAACAAGGTGTATTACTTCTCCAAAGGCACACTAAAAATTGCCAACAAGCAGTACACCTCTGTGAAGAACGACTATGAGATGACTTTCAACAGCGAGACGTCTGTTATTCCCTGTGACGACTCTGCTGATGTCCCAATGGTGCAGTTTGAATTTGTATCTATTGGCGAATTAGAAAGCAAGAATAAAGATACCGTTTTAGATATCATAGGCGTTTGTAAGAATGTTGAAGAGGTAACCAAGGTCACAATAAAATCCAACAACAGAGAAGTTTCTAAGAGGAGCATCCATCTAATGGATTCATCTGGCAAAGTGGTCTCAACAACTCTGTGGGGTGAAGATGCCGATAAATTTGATGGCTCCCGACAGCCTGTTGTTGCAATCAAAGGAGCAAGGCTTTCAGATTTCGGAGGGCGATCACTTTCAGTCTTGTCGTCTAGCACCGTAATGATCAATCCTGATATTCCTGAAGCATTCAAACTCCGTGCATGGTTTGACTCGGAGGGGCAAGTGGTAGAAGGAACATCAATCTCTGAATCTCGCGGTGGTGGAACGGGAGGTGGAAACACTAATTGGAAGTCTTTGTTAGAAGTGAAAAATGAAAACCTTGGCCATGGTGAAAAGGCAGATTATTTCACCAGCGTTGCTACAATCGTGTATCTTCGGAAGGAAAACTGTCTCTATCAGGCCTGCCCCTCACAAGACTGTAACAAAAAGGTGATAGATCAACAGAATGGCCTTTTCCGCTGTGAAAAATGCAACAAAGAATTTCCAAACTTCAAATATCGTCTCATCCTTTCAGCTAACATTGCTGACTTTGGGGAGAATCAGTGGATTACCTGCTTCCAAGAATCTGCTGAGAGTATTCTGGGCCAGAATGCTACTTATCTTGGAGAACTTAAGGAAAAAAACGAACAAGCCTATGATGAGGTGTTTCAGAATGCCAACTTCCGTTCTTACACGTTCAGGGCTCGAGTCAAGCTGGAGACATACAATGATGAATCTCGTATAAAGGCCACGGCCGTGGATGTGAAACCTGTTGACCACAAAGAATACTCTAGGAGGCTAATTATGAACATTAGGAAAATGGCAACTCAAGGTGTCTGATTTGCCATAAAGACCCTTTGATGAATCACTTAAAAGATGCAGGAGCAAAAAATAAAATGTCCCAATACTAAAGCACTGAAGCTT
Protein		Refseq >NP_001015732|replication protein A 70 kDa DNA-binding subunit [Xenopus (Silurana) tropicalis] MALPVLSEGAISAILGGDSSCKPTLQVINIRSINTGNGPPRYRLLMSDGLNTLSSFMLATQLNFLVDNNLLATNCICQVSRFIVNNLKDGRRVIIVMEMEVLKSADLVKGKIGNPHPYNDGQGPPQPAAPAPASAPPPSKPQNISAPPPPSMNRGASKLFGGGSVVNTPGGSQSKVVPIASLNPYQSKWTVRARVTNKGQIRTWSNSRGEGKLFSIEMVDESGEIRATAFNEQADKFFSLIEVNKVYYFSKGTLKIANKQYTSVKNDYEMTFNSETSVIPCDDSADVPMVQFEFVPIGELESKNKDTVLDIIGICKNAEEVTKVTIRSNNREVSKRNINLMDSSGKVVSTTLWGEDADKFDGSRQPVVAIKGARLSDFGGRSLSVLSSSTVMINPDIPEAFKLRAWFDSEGQVVEGTSISESRGGTGGGNTNWKSLLEVKTENLGHGEKADYFTSVATIVYLRKENCLYQACPSQDCNKKVIDQQNGLFRCEKCDKEFPNYKYRLILSANIADFGENQWITCFQESAESILGQNATYLGELKEKNEQAYDEVFQNANFRSYTFRIRVKLETYNDESRIKATAMDVKPVDHKEYSRRLIMNIRKMAAQGV UniProtKB	Refseq >NP_001081585|replication protein A 70 kDa DNA-binding subunit [Xenopus laevis] MALPQLSEGAISAMLGGDSSCKPTLQVINIRPINTGNGPPRYRLLMSDGLNTLSSFMLATQLNSLVDNNLLATNCICQVSRFIVNNLKDGRRVIIVMELDVLKSADLVMGKIGNPQPYNDGQPQPAAPAPASAPAPAPSKLQNNSAPPPSMNRGTSKLFGGGSLLNTPGGSQSKVVPIASLNPYQSKWTVRARVTNKGQIRTWSNSRGEGKLFSIEMVDESGEIRATAFNEQADKFFSIIEVNKVYYFSKGTLKIANKQYTSVKNDYEMTFNSETSVIPCDDSADVPMVQFEFVSIGELESKNKDTVLDIIGVCKNVEEVTKVTIKSNNREVSKRSIHLMDSSGKVVSTTLWGEDADKFDGSRQPVVAIKGARLSDFGGRSLSVLSSSTVMINPDIPEAFKLRAWFDSEGQVVEGTSISESRGGGTGGGNTNWKSLLEVKNENLGHGEKADYFTSVATIVYLRKENCLYQACPSQDCNKKVIDQQNGLFRCEKCNKEFPNFKYRLILSANIADFGENQWITCFQESAESILGQNATYLGELKEKNEQAYDEVFQNANFRSYTFRARVKLETYNDESRIKATAVDVKPVDHKEYSRRLIMNIRKMATQGV UniProtKB

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.23569	Xl.3957
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		1 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	RPA1
mouse		MGI	Rpa1	All(4) Targeted, other(3)
zebrafish		ZFIN	rpa1	5 Lines(s)

Publications
First:		Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A. [J Cell Biol 1992]
Most recent:		The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. [Mol Biol Cell 2013]
		View All Papers

Functional Ontologies
GO: Molecular:		DNA binding nucleic acid binding
Biological:		DNA replication
Cellular Component:		nucleus
EC:
KOG:		[L] Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.10339.1.S1_s_at	Xl.3957.1.S1_at
Affymetrix 2.0			Xl2.3957.1.S1_at

Symbol legend[+]

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   - Literature Or Expression Images