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Summary Expression Gene Literature (13) GO Terms (14) Nucleotides (56) Proteins (26) Interactants (406) Wiki
XB-GENEPAGE-946234
Gene Symbol: rspo2

Gene Name: R-spondin 2

Synonyms: CRISTIN2 , R-spondin 2 ( Add synonyms , Nomenclature history )

Gene Function: Subtilisin-like proprotein convertase

Protein Function :
Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptor...[+]


Interactants: Loading ...
OMIM Diseases: HUMEROFEMORAL HYPOPLASIA WITH RADIOTIBIAL RAY DEFICIENCY; HHRRD [+]

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Xenbase Gene ID XB-GENE-946235 XB-GENE-946240 XB-GENE-17333621
Gene Symbol rspo2 rspo2.L rspo2.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.1 Version 9.1
CDS Gene model
Entrez Gene: 496854
Entrez Gene: 496383
Entrez Gene: 108719754
mRNA RefSeq RefSeq NCBI Nucleotide
Protein RefSeq TrEMBL Swiss-Prot RefSeq Swiss-Prot TrEMBL NCBI Protein
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression
Data Mining tropicalis laevis.L laevis.S
XenMine rspo2 rspo2.L rspo2.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards RSPO2 OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Rspo2 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
rspo2 ZFIN Ensembl
chicken
GEISHA RSPO2 Ensembl
fruit fly
worm
WORMBASE
Publications
First R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis., Dev Cell 2004                            
Most Recent ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia., Cell Rep 2019                                
All View All Papers 4 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 13 terms 5 terms 0 term
PANTHER rspo2
KEGG Pathways K23097 K23097
KOG [O] Subtilisin-like proprotein convertase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
Horizon Horizon Horizon
Morpholino rspo2 MO1 rspo2 MO1 rspo2 MO1
ORF rspo2 ORF1
Affymetrix 1.0 Str.5159.1.S1_at
Affymetrix 2.0 Xl2.49496.1.S1_at

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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Version: 4.12.3


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