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Summary Expression Gene Literature (18) GO Terms (14) Nucleotides (71) Proteins (33) Interactants (500) Wiki
XB-GENEPAGE-946234
Gene Symbol:
rspo2

Gene Name:
R-spondin 2

Synonyms:
CRISTIN2 , R-spondin 2 ( Add synonyms , Nomenclature history )

Gene Function:
Subtilisin-like proprotein convertase

Protein Function :
Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptor...[+]



Interactants:
Loading ...

Diseases: 


OMIM:
HUMEROFEMORAL HYPOPLASIA WITH RADIOTIBIAL RAY DEFICIENCY; HHRRD [+]

External Links:
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Xenbase Gene ID XB-GENE-946235 XB-GENE-946240 XB-GENE-17333621
Gene Symbol rspo2 rspo2.L rspo2.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 496854
496383
108719754
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. NCBI Protein
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine rspo2 rspo2.L rspo2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards RSPO2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Rspo2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Rspo2 Ensembl
zebrafish
rspo2 Ensembl
chicken
GEISHA RSPO2 Ensembl
fruit fly
worm
Publications
First R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis., Dev Cell 2004                            
Most Recent R-spondins are BMP receptor antagonists in Xenopus early embryonic development., Nat Commun 2020                                              
All View All Papers 4 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 6 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 13 terms 5 terms 0 term
PANTHER rspo2
KEGG Pathways K23097 K23097
KOG [O] Subtilisin-like proprotein convertase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks rspo2
Morpholinos (on-target & off-target) rspo2 MO3 , rspo2 MO2 , rspo2 MO1 rspo2 MO2 , rspo2 MO3 , rspo2 MO1
ORFs rspo2 ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info