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Summary Expression Gene Literature (63) GO Terms (7) Nucleotides (275) Proteins (33) Interactants (162) Wiki
XB-GENEPAGE- 950934

Gene Symbol: pam

Gene Name: peptidylglycine alpha-amidating monooxygenase

Synonyms: pal , phm , pam-a , pam-b , AE-I
Add Xenopus synonyms , Nomenclature history


Gene Function: Peptidylglycine alpha-amidating monooxygenase

Protein Function :
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated t...[+]


Interactants: Loading ...

Disease Ontology Associations:

OMIM Disease Associations: PEPTIDYLGLYCINE ALPHA-AMIDATING MONOOXYGENASE; PAM
 
Xenbase Gene ID XB-GENE-950935 XB-GENE-950939 XB-GENE-6252615
Gene Symbol pam pam.L pam.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence Genomic sequence Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
Entrez Gene
mRNA Refseq Refseq Refseq
Protein Refseq TrEMBL Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.65164 Xl.417 Xl.536
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine pam pam.L pam.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards PAM OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Pam MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR pam ZFIN Ensembl
chicken
GEISHA PAM Ensembl
fruit fly
worm
WORMBASE
Publications
First: Peptide C-terminal alpha-amidating enzyme purified to homogeneity from Xenopus laevis skin. [Biochem Biophys Res Commun 1986]
Most recent: An analysis of MyoD-dependent transcription using CRISPR/Cas9 gene targeting in Xenopus tropicalis embryos. [Mech Dev 2017]
View All Papers 1 paper(s) referencing Disease Ontologies
Functional Ontologies tropicalis laevis.L laevis.S
GO 1 terms 7 terms 7 terms
PANTHER pam
KEGG Pathways K00504 [+] K00504 [+]
KOG [O] Peptidylglycine alpha-amidating monooxygenase
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience Source BioScience
Affymetrix 1.0 Str.40574.2.S2_at [+] Xl.417.1.S1_at [+] Xl.536.1.S1_at
Affymetrix 2.0 Xl2.417.1.S1_at [+] Xl2.536.1.S1_a_at

Symbol legend[+]
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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556