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Summary Expression Gene Literature (15) GO Terms (18) Nucleotides (86) Proteins (35) Interactants (178) Wiki
XB-GENEPAGE-954189
Gene Symbol:
fbn1

Gene Name:
fibrillin 1

Synonyms:
fibrillin , xf ( Add synonyms , Nomenclature history )

Gene Function:
Fibrillins and related proteins containing Ca2+-binding EGF-like domains

Protein Function :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.



Interactants:
Loading ...

Diseases: 


Disease Ontology:
Weill-Marchesani syndrome [+]

OMIM:
ECTOPIA LENTIS 1, ISOLATED, AUTOSOMAL DOMINANT; ECTOL1 [+]

External Links:
 
Xenbase Gene ID XB-GENE-954190 XB-GENE-6487589 XB-GENE-17346022
Gene Symbol fbn1 fbn1.L fbn1.S
Chromosome Chr03 chr3L chr3S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 100490545
108711397
108712909
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine fbn1 fbn1.L fbn1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards FBN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Fbn1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Fbn1 Ensembl
zebrafish
fbn1 Ensembl
chicken
GEISHA FBN1 Ensembl
fruit fly
worm
Publications
First Identification of the developmental marker, JB3-antigen, as fibrillin-2 and its de novo organization into embryonic microfibrous arrays., Dev Dyn 1998  
Most Recent Conservation and divergence of protein pathways in the vertebrate heart., PLoS Biol 2019                                                      
All View All Papers 4 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 4 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 18 terms 1 terms 1 terms
PANTHER fbn1
KEGG Pathways K06825 K06825
KOG [T] Fibrillins and related proteins containing Ca2+-binding EGF-like domains
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks fbn1
Clones Horizon Horizon Horizon

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