Gene Symbol: sp7 Gene Name: Sp7 transcription factor Synonyms: osx, osterix Add Xenopus synonyms Gene Function: zinc finger, C2H2 type Interactants: runx2(2) , col1a1(1) , dkk1(1) , gdf5(1) , mid1(1) , mmp1(1) , myc(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1 Ensembl 4.1	JGI XL Genome 6.0
		Entrez Gene	Entrez Gene
mRNA		Refseq >NM_001135118|Xenopus (Silurana) tropicalis Sp7 transcription factor (sp7), mRNA GATCTCCAGGAGCGCTCACTCACACACAGGGGGGGTATGGCTTCTCCCATGCTAGAGGAAGAAGCTCGTTATGTTTCCAGCCCTTTAGCAATGCTCACTGCTGCTTGCAACAAGTTTGGGGGTTCCAGCCCTATCAGGGATTCCACCTCCTCATCTAAGTCTGGAGTGAAGAAGCCATACAGCCAAACCAATGAATTCAGTGCCTCAAAACTAATGGGGGACGGATATTCTTCTGCATACTTGGGGGGAAGCAATATAATGACACCGTGTGGGACACCCCCTGCACCTTCAAACTATGGAGGAGACTTTGGATCCTTCTCTCATTCCTTCTCTTCCTCTTCAGGATGCCAAGAGCCCAAGAGTCTCTCTCCAGCAGAGTGTGTGCCTAGTGTGTACACTTCATTAGATATGGGACATCCGTATGGCTCATGGTACAAAACAGGCATACATCATCCTTCTCTGTCTAGTTCACCCCCAGGCAGTGGTGGTTCATGGTGGGACATGCATCCAAATACAAACTGGCTAGGAAACCAGTCACAGCCAGATGGGCTGGCAGCTTCCATGCCACCAGTAACAAGTCCAGTAGGCATGAGCAGCCAGTATAGTGCAGAATACACCACTCTTACCCCTGCTACATACCCTTCTGTGGGGTTTCCCTCAATCTCTCCATCCTCAAGCCCATCCCCATCTTCACACCTTCTGTCACCTTCCCAGCACACATTGGCCCCGGAAATGTACAAGCCAAAGCTTTTGGCTGCTAACCCCTTGCTAGAAACACCAGGATCTTTAAAGGCCCAAAGGGGAACATCATATGGAAACTCTGGCCGTCCGTCATGTGACTGTCCAAACTGCCAAGAGCTGGAGAGGCTAGGAGCTTCTGCTGCCAGTCTGAAAAGGAAGCCGGTGCACAGCTGTCACATTCCTGGGTGTGGGAAAGTGTACGGTAAAGCTTCACATCTCAAAGCTCACCTACGCTGGCACACAGGAGAGCGTCCTTTTGTTTGCAACTGGCTTTTCTGTGGAAAACGTTTCACACGTAGTGATGAGCTTGAACGCCATGTGCGCACCCACACACGTGAGAAAAAGTTCACTTGCCCACTCTGTGCAAAAAGATTCACACGCAGCGACCACTTAAGCAAGCACCAGCGCAGCCATGTTGATCAGCCAGGAGCAAAAGATGATGGAGTTCAAGGAGATGGGGGGGCAGTGGGCGAGAGCTCTGCTGAAAAGGGCATAGTGTTATCTGACAGCTCACCTGCAGGTGGTAGCCAAGAAAGGGCATCTGGTAGCCCTGGCCAAGGAGGTTTGTTAGAAATATGATTCTGGAGAATCTCTGATAATGGGCCAG	Refseq >NM_001099905|Xenopus laevis Sp7 transcription factor (sp7), mRNA CTCACAGACAGGAGGGGAATGGCATCTCCCATGCTAGAGGAAGAAGCTCGTTATGTTTCCAGCCCTTTAGCAATGCTCACTGCTGCCTGTAACAAGTTTGGGGGTTCCAGCCCTATCAGGGATTCAACAGCTTCAGCCAAATCTGGAGTGAAGAAGCCATACAGCCAAGTCAATGACTTCACTGCCTCAAAACTAATGGGGGATGGATATTCTTCTACATACTTAGGGGGAAGCAATATAATGACGTCATGTGGGACCCCCCCTGCATCATCAAACTACGGAGGAGAGTTTGGATCTTTCGCTCATTCCTTCCCTTCCTCTTCAGGATGCCAAGAACCCAAGAGTCTCTCACAAGCAGAGTGTGTGCCTGGCGTGTACACTTCATTAGATATGGGACATCCATATGGCTCTTGGTACAAAACAGGCATTCATCATCCTTCTCTGTCTAGTTCACCCCCAGGCAGTGGTGGTTCATGGTGGGACATGCATCCAAATACAAACTGGCTTGGAAACCAGTCACAGCCGGATGGGCTGGCAGCTTCCATGCCACCTGTAACAAGTCCAGTAGGCATGAGCACCCAATATAGTGCAGAATACACCACTCTTACCCCTGCCACATACCCCTCTGTGGGGTTTCCCTCCATCTCTCCTTCATCAAGCCCATCCCCATCTTCACACCTCCTGTCACCCTCCCAGCACACATTGGCCCCAGAAATGTACAAGCCAAAGCTTTTGGCTGCTAACCCCTTGCTAGAAAGCCCAGGGTCTTTAAAGGCCCAAAGGGGAACATCATATGGGAACTCTGGCCGTCCGACATGTGACTGTCCAAACTGCCAGGAGCTGGAGAGACTAGGAGCTTCTGCTGCAGGTCTGAAGAGGAAGCCGGTGCACAGCTGTCACATCCCTGGCTGTGGAAAAGTGTATGGTAAAGCTTCACATCTCAAAGCTCACCTACGCTGGCACACAGGAGAGCGTCCTTTTGTTTGCAACTGGCTTTTCTGTGGCAAACGCTTCACGCGTAGCGATGAGCTTGAACGCCATGTGCGCACCCACACACGTGAGAAAAAGTTCACTTGCCCACTCTGTGCAAAAAGGTTCACTCGCAGTGACCACTTAAGCAAACACCAGCGCAGCCATGTTGATCAGCCAGCAGCAAAAGATGATGGAGTTCAAGGAGATGGAGGAGCAGTGGGCGAGAGCTGTGGCGAAAAAGGCATAGTATTATCCGAAAGCTCACCAGCCGGTGGTACCCAAGAAAGGGCATCTGGTAGCCCTGGCCAAGGAGGCTTGTTAGAAATATGATGCTGAAGAACTTCCATAACAGGCCACAGGCTTATTAGAGCTGTACGGCATCTATAAAACACCTTAGCAGCTGTGCTCTTGCTTTGTGATGCAGGCCGCCTTTTTAAAGATGGGAAAAGTGAAGGACAAACATAGGCTAAAGACTGTGCCTAAACTCTTGGCTCTTGAGCCAGAATGGAGGCAGTGTGTAAACTGTGTATCATGTTTAAATATTTGCAAAATGTATTCCCCCTGGTAGTGTGTGTTCTTTGCACAAGAGGATGAGTTATTTATAGTGTTAACATAGGGAATCTAATTTCAACACATTCAGAAATATGAGCTAACTGGTCTACTACCCCCCTCCACTTCCAGGGTTTTACTGGACAGTGTAACCCAATGGTTCATGAAGCTGAAACAAGCCCCTCTAGCACTAGAGGTGCATCCAGTACAAGTGAAAATAGTGTTATTGTGTGATCTTTATTCTTTATGATGAAATATGAGCAGAGGGGGACTCTTGTGCTATTACCTAAAATGGGAAGTGGAAACTGGCTGCCATGCCACTTAATAGAATACACACAATTGATCAAAACAACCCCTGTGCCATTGTAGAACAAACAGTAAATATGGGGTTCTACTCCCTTGGGTATTCTATATAATTGGCACAAATGCATGGAATGGTTTTATGGTGATGGAGGAACGAAGCTGATCTAGGTTCAGTTTTCCTATTCATGTGTAAAAACTCATTAAAAGGGAAAGTTAACCTTAAACTTAGCCTTTCATTTGACTTAGACATTTGTATTCCAAGACAGTTTACAGTTTTCTTCATTGTTGTTTCATGTAAGTTTATTTATTGATTTTTTTGTTTATAAAATTAATCAACCAAAATATTTTAAGAAATACATGACTTGTAGCATTTTCTCTGTATAAAAATGCCAGATCTCATATGTGTCTCCTGTTGTTGACTATAATGGACAACTGCCAACAGATTTCCATTATAGTCAATTACAGGTTGCAGGGCTAGGTTCTGGCATTTTTCTGCCAGTAATAAAATGTTGTACGGTGCCCTTGCCCCATGGTCATGAATGGCCCCTTTTATTTATATGTATACAAGACATTTTGTTTTGGTGTCACTGATCCTTTTATGTATTGTTCCCAGCACATCAGGGTGGAATTTTAACATTTTAGCATTGTGTTTGAAGTCAGGCAATGATTTAAACACCTGAAGAGAAAATTATTCATTCAAATCAACATTCAGGTTTCGGTATTTCTGTATTATAATGTCAAAATGCTAAACAAAACCCCACCCTGTCTATTGCATTCGGTGTTGGCATGATACATATTCATGACCTGCCCCCAAAGGCCCAGCAAAACAAAACTAAAAGTATTTTATATAGTATTGTGTTCTGTAGTAAGGCTACACAGGGCATTTTTACTTTATAGTGTTACTTTCCCTTTAAATGAATGGAAAATAAATAGCAGTGGGACACCATAGATTAGTGTCTCTGACTCTAGCAATGAACCATGAGCAGTTTGCATTTTCTTTAATAAATATCCATTTTTATTTTTTAACTGAAGGCATAATAGAGATCCTCTTTCATTTAACTGCTCATTTGGACAAAAGAGAGGGGGCAATGTGCCTTTTGCTTGAACGTGTAAGTGCTTTAAGATTTTGCATTCCATAGTGGTGCTAAACAAGCTCGTCCTCTCTGATTCCATTTGTGCGTGGGCCAATGTGCAAACCACAGAGGGTCCCACTGATGGTAAATGGGTTAATGCTGTGGAAATGTTGAAGTGCACTTTCATAAGCTGTATTATTAATATTGCACTCTGTACTGTAAGCTGTGGGGAAGCCATACATTACCATGATTAGTTACCTGTAAAATTAGATGTATTTCCCACAGACATTACTTTGTTTTTTAAGAGGTTTTTTTGCGTGTTTTAAAACATATATGTATTGCTAAAAACATAAGGTTTTATAAGGTTAAGTCACAATGGTGTAACTAGAAGTTAGTAGGCCACACTGAAAAATCATGTTAGGGCCCCATACTTTCCAGAAACTGGCTTTTGTCTAATATGTATAATGTATATAGAACTTCCACATCATTAAATACTACATTGGAAAAAAAAAAAAAAAAAAAAAAAAA
Protein		Refseq >NP_001128590|Transcription factor Sp7 [Xenopus (Silurana) tropicalis] MASPMLEEEARYVSSPLAMLTAACNKFGGSSPIRDSTSSSKSGVKKPYSQTNEFSASKLMGDGYSSAYLGGSNIMTPCGTPPAPSNYGGDFGSFSHSFSSSSGCQEPKSLSPAECVPSVYTSLDMGHPYGSWYKTGIHHPSLSSSPPGSGGSWWDMHPNTNWLGNQSQPDGLAASMPPVTSPVGMSSQYSAEYTTLTPATYPSVGFPSISPSSSPSPSSHLLSPSQHTLAPEMYKPKLLAANPLLETPGSLKAQRGTSYGNSGRPSCDCPNCQELERLGASAASLKRKPVHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCPLCAKRFTRSDHLSKHQRSHVDQPGAKDDGVQGDGGAVGESSAEKGIVLSDSSPAGGSQERASGSPGQGGLLEI	Refseq >NP_001093375|Transcription factor Sp7 [Xenopus laevis] MASPMLEEEARYVSSPLAMLTAACNKFGGSSPIRDSTASAKSGVKKPYSQVNDFTASKLMGDGYSSTYLGGSNIMTSCGTPPASSNYGGEFGSFAHSFPSSSGCQEPKSLSQAECVPGVYTSLDMGHPYGSWYKTGIHHPSLSSSPPGSGGSWWDMHPNTNWLGNQSQPDGLAASMPPVTSPVGMSTQYSAEYTTLTPATYPSVGFPSISPSSSPSPSSHLLSPSQHTLAPEMYKPKLLAANPLLESPGSLKAQRGTSYGNSGRPTCDCPNCQELERLGASAAGLKRKPVHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCPLCAKRFTRSDHLSKHQRSHVDQPAAKDDGVQGDGGAVGESCGEKGIVLSESSPAGGTQERASGSPGQGGLLEI

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI Ensembl UCSC		Xenbase
Synteny		Metazome

Expression		tropicalis	laevis
UniGene		Str.84042 [+] Str.10975	Xl.73455 [+] Xl.8933
Unigene EST Profile		EST Profile	EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	SP7
mouse		MGI	Sp7	All(6) Targeted, other(4)
zebrafish		ZFIN	sp7

Publications
First:		Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. [Proc Natl Acad Sci U S A 2008]
Most recent:		Effects of fluoride on expression of bone-specific genes in developing Xenopus laevis larvae. [Biochem Cell Biol 2011]
		View All Papers

Functional Ontologies
GO: Molecular:		nucleic acid binding zinc ion binding
Biological:
Cellular Component:		nucleus
EC:
KOG:		[R] FOG: Zn-finger

Reagents		tropicalis	laevis
Clones		open biosystems	open biosystems
		geneservice/RZPD imagenes	geneservice/RZPD imagenes
Affymetrix 1.0		Str.10975.1.A1_at [+] StrEns.4935.1.S1_at	Xl.8933.1.A1_at
Affymetrix 2.0			Xl2.50523.1.S1_at [+] Xl2.8933.1.A1_at

Symbol legend[+]

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   - Literature Or Expression Images