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Summary Expression Gene Literature (2) GO Terms (13) Nucleotides (126) Proteins (21) Interactants (46) Wiki
XB-GENEPAGE-954419
Gene Symbol: letm1

Gene Name: leucine zipper-EF-hand containing transmembrane protein 1

Synonyms: ( Add synonyms , Nomenclature history )

Gene Function: Ca2+-binding transmembrane protein LETM1/MRS7

Protein Function :
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Required for the maintenance of the tubular shape and cristae organization.

Interactants: Loading ...
Diseases:  Disease Ontology: Wolf-Hirschhorn syndrome

OMIM: WOLF-HIRSCHHORN SYNDROME; WHS

External Disease Links: ClinVar, MalaCards, KEGG Disease, DECIPHER
 
Xenbase Gene ID XB-GENE-954420 XB-GENE-17338407 XB-GENE-6485788
Gene Symbol letm1 letm1.L letm1.S
Chromosome Chr01 chr1L chr1S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 780254
108697680
108706514
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot NCBI Protein TrEMBL NCBI Protein TrEMBL
Genomic tropicalis laevis.L laevis.S
Genome Browser
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine letm1 letm1.L letm1.S
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards LETM1 OMIM Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Letm1 MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR letm1 ZFIN Ensembl
chicken
GEISHA LETM1 Ensembl
fruit fly
FLYBASE Letm1 Ensembl
worm
WORMBASE
Publications
First Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis., Front Physiol 2019                            
Most Recent The Many Faces of Xenopus: Xenopus laevis as a Model System to Study Wolf-Hirschhorn Syndrome., Front Physiol 2019            
All View All Papers 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 12 terms 4 terms 4 terms
PANTHER letm1
KEGG Pathways K17800
KOG [S] Ca2+-binding transmembrane protein LETM1/MRS7
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks letm1
Morpholinos letm1 letm1 letm1
Clones Horizon Source BioScience Horizon Horizon Source BioScience

Symbol legend: - Blast this sequence    - View this sequence       - Literature or expression images  
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