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Summary Expression Gene Literature (29) GO Terms (6) Nucleotides (323) Proteins (54) Interactants (847) Wiki
XB-GENEPAGE-956214
Gene Symbol:
ezh2

Gene Name:
enhancer of zeste 2 polycomb repressive complex 2 subunit

Synonyms:
enx1 , ezh1 , kmt6 , enx-1 , xez , xtezh2 , ezh2-a , ezh2-b ( Add synonyms , Nomenclature history )

Gene Function:
Transcriptional repressor EZH1

Protein Function :
Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
Weaver syndrome

OMIM:
WEAVER SYNDROME; WVS

External Links:
1/8
 
Xenbase Gene ID XB-GENE-956215 XB-GENE-956220 XB-GENE-6252001
Gene Symbol ezh2 ezh2.L ezh2.S
Chromosome Chr06 chr6L chr6S
Molecules tropicalis laevis.L laevis.S
Genomic Sequence Version 9.1 Version 9.2 Version 9.2
CDS Gene model Gene model Gene model
Entrez Gene 550047
399174
100381148
mRNA RefSeq RefSeq RefSeq
Protein RefSeq Swiss-Prot RefSeq Swiss-Prot Swiss-Prot RefSeq Swiss-Prot
Genomic
tropicalis laevis.L laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics tropicalis laevis.L laevis.S
Embryonic Protein Expression Stage profile:
Data Mining tropicalis laevis.L laevis.S
XenMine ezh2 ezh2.L ezh2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards EZH2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Ezh2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Ezh2 Ensembl
zebrafish
ZFIN, AGR ezh2 ZFIN Ensembl
chicken
GEISHA EZH2 Ensembl
fruit fly
worm
Publications
First The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos., Mol Cell Biol 2001  
Most Recent RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis., Oncogene 2020            
All View All Papers 3 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies tropicalis laevis.L laevis.S
GO 6 terms 5 terms 5 terms
PANTHER ezh2
KEGG Pathways K11430 K11430 K11430
KOG [K] Transcriptional repressor EZH1
Reagents tropicalis laevis.L laevis.S
CRISPRscan Tracks ezh2
Mutants Xtr.ezh2emHorb
Antibodies Ezh2 Ab1 Ezh2 Ab1 Ezh2 Ab1
Morpholinos ezh2 MO1 , ezh2 MO2 ezh2 MO1 , ezh2 MO2 ezh2 MO1 , ezh2 MO2
ORFs ezh2.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list
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