[provisional- machine annotated only] Gene Symbol: itk [Predicted: Source is Human Entrez Gene] Gene Name: IL2-inducible T-cell kinase [Predicted: Source is Human Entrez Gene] Synonyms: emt, lyk, psctk2 Add Xenopus synonyms Gene Function: Tyrosine kinases Interactants: cdh1(4) , snai1(4) , snai2(4) , sox9(2) , twist1(2) , xk81a1(2) , acta1(1) View All

Molecules		tropicalis	laevis
Gene		JGI XT Genome 7.1 JGI XT Genome 4.1
		Entrez Gene
mRNA		NCBI Nucleotide >XM_002939610|PREDICTED: Xenopus (Silurana) tropicalis tyrosine-protein kinase ITK/TSK-like (LOC100492561), mRNA ATGAATAACCCTGTTATCCTGCAACAACAGCTTATTAAGAAGTCCCAGCAGAAGAGAAGGACGTCCCCAGCTAACTACAAGTCCAGGATCTTCATCCTGACCCACTCTTCACTCAACTACTACGAGCATCGGCAAGGGAAAATACGTGCTCTCCGTGGCTCCATTGACTTGGCTCGGATTAAATGTGTCGAGATTGTTACCACTGATCTCAGCATTGCTTGCAGGAACAAATACCCATTTCAGGTTATCCATGATTATTTTCTGTACGTCTTTGCTCCTGACAGAGAGAGTCGTCAAAAGTGGGTGCTGGCACTGAAAGAAGAGACCAAAGACAATGACTTTCTTGTGGCTAAATATCACTCCAACTTCTGGTTGGAAGGGAGATGGAGATGTTGCTTCCAGACAGAGAAAATGGCCACCGGCTGTGCCTTGTACGACAGGAGCAAAGATGTCTCAAAGAAGCCTCTGCCCCCCACACCCAATGACAACATGGTCTTCCAGGCGAACCAAGGCTGGGAGGTGGCACTGTATGATTACAAGGCACAAAGCAGCCAGGAGCTGACGCTTTGTAGAGGGGAAGAATATCTGCCACTGGACACATCAGAACCTCATTGGTGGAAAGTTCTGGATAAAAATGGGTGGGGTAAAGAAGGAGCCTTTATGGTTCGAGACTCAAGGCAGCCGGGGTTGTACACTGTATCCATCTTCACCAAAGCTCTTGGAGAGAACAATCATGCAGTGAAACATTACCATATCCGCCACACAAATGACTCCCCAGCCAAATATTACCTGGCTGAGAAGCACGTCTTCAACTCCATCCCCGAGCTAATTAACTACCACCAGCATAACGGAGCAGTATTGAAAATAATGCTTATTCACGGTTTTAGTTGATGATGCTGTTGACGGGATTCCAAGCCTTTTTTTGTTCTCTGATCCATAGGTAAGTGGGAAATTGACCCCACACACCTGACACTCAAGGAAGAGATTGGCAGTGGCCAGTTTGGGGTTGTACAGCTGGCAATATGGCAGGGCACTACCAAAGTGGCAGTAAAGATGATTCGGGAAGGGATGATGTCTGAGGAGGACTTTGTGGAGGAAGCCCAGGTCCTTATGAAACTTTCTCACCCTAAATTGGTGCAGCTTCTGGGAGTTTGCACCCAACAGGTGCCCATTTTTCTAGTGTTTGAGTACATGAAATATGGCTGCCTGTTTAACTACCTGCGCAGTCATCGAGGGACGCTCTCCAAGGAAACAGCTTTGGGGATGTGCCAGGATGTATGTGAGGGGATGCAGTACTTGGAAAGGTCCAATTTTATTCACAGGGACTTGGCTGCACGCAACTGCCTGGTGGGGGAATCATTGGTAGTCAAGGTTTCAGATTTTGGGATGACCAGGTTTGTTCTGGATGATCAGTACACCAGCTCCTCTGGCACCAAATTTCCTGTTAAATGGTCGGCTCCAGAAGTTTTCCGTTTTGGCCTTTACAGCAGCAGATCCGATGTGTGGTCCTTTGGAGTGTTGGTGTGGGAGGTGTTTAGTGAAGGCAAGATCCCATTTGAACACCTTTCCAACTCTGAAGCTGTTGAAAAAATCTCAGCTGGACTGAGGCTTTTCAAACCAAAGATGTCTTCTGAAAGAGTGTACAAGCTGATGAACAACTGCTGGCAAGAGAAAGCAGATTTACGTCCAACATTCCAACAACTACTGAAAGAGGTCATGGACATTGCAGAATGTGACATGTGA
Protein		NCBI Protein >XP_002939656|PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein kinase ITK/TSK-like [Xenopus (Silurana) tropicalis] MNNPVILQQQLIKKSQQKRRTSPANYKSRIFILTHSSLNYYEHRQGKIRALRGSIDLARIKCVEIVTTDLSIACRNKYPFQVIHDYFLYVFAPDRESRQKWVLALKEETKDNDFLVAKYHSNFWLEGRWRCCFQTEKMATGCALYDRSKDVSKKPLPPTPNDNMVFQANQGWEVALYDYKAQSSQELTLCRGEEYLPLDTSEPHWWKVLDKNGWGKEGAFMVRDSRQPGLYTVSIFTKALGENNHAVKHYHIRHTNDSPAKYYLAEKHVFNSIPELINYHQHNGAVLKIMLIHGFSXXCCXRDSKPFFVLXSIGKWEIDPTHLTLKEEIGSGQFGVVQLAIWQGTTKVAVKMIREGMMSEEDFVEEAQVLMKLSHPKLVQLLGVCTQQVPIFLVFEYMKYGCLFNYLRSHRGTLSKETALGMCQDVCEGMQYLERSNFIHRDLAARNCLVGESLVVKVSDFGMTRFVLDDQYTSSSGTKFPVKWSAPEVFRFGLYSSRSDVWSFGVLVWEVFSEGKIPFEHLSNSEAVEKISAGLRLFKPKMSSERVYKLMNNCWQEKADLRPTFQQLLKEVMDIAECDM

Genomic		tropicalis
Genome Browser		Xenbase	Xenbase JGI UCSC
Synteny		Metazome

Expression		tropicalis	laevis
UniGene
Unigene EST Profile
GEO data			GEO
Images		0 expression image(s) for tropicalis and laevis

Orthology		MOD	Entrez Gene	Genetic Phenotypes	Morphants
human		OMIM:Gene, HGNC	ITK
mouse		MGI	Itk	All(5) Targeted, knock Out(2) Targeted, other(3)
zebrafish		ZFIN	itk	1 Lines(s)

Publications
First:		Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. [Mech Dev 2003]
Most recent:		Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migration. [Dev Biol 2012]
		View All Papers 2 paper(s) referencing morpholinos

Functional Ontologies
GO: Molecular:		ATP binding protein kinase activity protein serine/threonine kinase activity More[+] protein tyrosine kinase activity
Biological:		intracellular signaling cascade protein amino acid phosphorylation
Cellular Component:
EC:		now EC:2.7.10.1 and EC:2.7.10.2
KOG:		[T] Tyrosine kinases

Reagents		tropicalis	laevis
Clones
Affymetrix 1.0		StrJgi.4614.1.S1_at
Affymetrix 2.0

Symbol legend[+]

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