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Summary Expression Gene Literature (46) GO Terms (30) Nucleotides (82) Proteins (33) Interactants (219) Wiki
XB-GENEPAGE-957955
Gene Symbol:
mre11

Gene Name:
MRE11 homolog , double strand break repair nuclease

Synonyms:
mre11a ( Add synonyms , Nomenclature history )

Gene Function:
DNA repair exonuclease MRE11

Protein Function :
Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.


InterPro :
PKHA4/5/6/7 PH , PH domain , PH-like dom sf , Metallo-depent PP-like [+]

Interactants:
Loading ...

Diseases: 


OMIM:
ATAXIA-TELANGIECTASIA-LIKE DISORDER 1; ATLD1

External Links:
 
Xenbase Gene ID XB-GENE-957956 XB-GENE-957959 XB-GENE-17332692
Gene Symbol mre11 mre11.L mre11.S
Chromosome Chr2 chr2L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 100135381
394308
mRNA NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mre11 mre11.L mre11.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards MRE11 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mre11a MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mre11 Ensembl
zebrafish
ZFIN, AGR mre11a ZFIN Ensembl
chicken
GEISHA MRE11 Ensembl
fruit fly
FLYBASE mre11 Ensembl
Publications
First Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication., Mol Cell 2001  
Most Recent Conservation and divergence of protein pathways in the vertebrate heart., PLoS Biol 2019                                                      
All View All Papers 2 paper(s) referencing OMIMs 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 26 terms 11 terms 0 term
PANTHER mre11
KEGG Pathways K10865 K10865
KOG [L] DNA repair exonuclease MRE11
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mre11
Antibodies Mre11a Ab1 Mre11a Ab1 Mre11a Ab1
ORFs mre11.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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