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Summary Expression Gene Literature (5) GO Terms (3) Nucleotides (38) Proteins (24) Interactants (44) Wiki
XB-GENEPAGE-960721
Gene Symbol:
mc4r

Gene Name:
melanocortin 4 receptor

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Glycoprotein hormone receptor

Protein Function :
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediat...[+]


InterPro :
GPCR Rhodpsn 7TM , Melcrt ACTH rcpt , Mcort rcpt 4 , GPCR Rhodpsn [+]

Interactants:
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Diseases: 


Disease Ontology:
obesity

OMIM:
OBESITY

External Links:
 
Xenbase Gene ID XB-GENE-960722 XB-GENE-17343871 XB-GENE-17343872
Gene Symbol mc4r mc4r.L mc4r.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100486677
108719094
108695258
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein NCBI Protein TrEMBL
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mc4r mc4r.L mc4r.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards MC4R OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mc4r MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mc4r Ensembl
zebrafish
ZFIN, AGR mc4r ZFIN Ensembl
chicken
GEISHA MC4R Ensembl
fruit fly
Publications
First Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein., Science 1997  
Most Recent Pharmacological modulation of dual melanocortin-4 receptor signaling by melanocortin receptor accessory proteins in the Xenopus laevis., J Cell Physiol 2021  
All View All Papers 1 paper(s) referencing OMIMs
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 0 term 3 terms 3 terms
PANTHER mc4r
KEGG Pathways K04202 K04202
KOG [T] Glycoprotein hormone receptor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mc4r
Morpholinos mc4r MO2
Clones Horizon Horizon Horizon
Plasmids Addgene Addgene

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