Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (44) GO Terms (18) Nucleotides (146) Proteins (31) Interactants (178) Wiki
XB-GENEPAGE- 964547

Gene Symbol: mastl

Gene Name: microtubule associated serine/threonine kinase like

Synonyms: greatwall , gwl , mast-l , thc2 , gw
Add Xenopus synonyms , Nomenclature history


Gene Function: cAMP-dependent protein kinase catalytic subunit (PKA)

Protein Function :
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: d...[+]


Interactants: Loading ...

Disease Ontology:
   THROMBOCYTOPENIA

OMIM Diseases:
   THROMBOCYTOPENIA 2; THC2
 

Xenbase Gene ID XB-GENE-964548 XB-GENE-964551 XB-GENE-17339965
Gene Symbol mastl mastl.L mastl.S
Chromosome Chr06 Scaffold17434
Molecules tropicalis laevis.L laevis.S
Gene Genomic sequence
CDS Gene model
Entrez Gene
Entrez Gene
mRNA Refseq Refseq
Protein Refseq Swiss-Prot TrEMBL Refseq Swiss-Prot
Genomic tropicalis laevis.L laevis.S
Genome Browser
Links
Genomic Synteny Genomicus PANTHER
Expression tropicalis laevis.L laevis.S
Ensembl Ensembl
UniGene Str.3977 Xl.3201
RNA-Seq profile Stage profile: Stage profile:       Tissue heatmap:
Experimental regulation Regulation heatmap:
Images 0 expression image(s) for tropicalis and laevis
Data Mining tropicalis laevis.L laevis.S
XenMine mastl mastl.L mastl.S
Phenotype tropicalis laevis.L laevis.S
Smith Morpholino Screen    
Orthology
MOD Entrez Gene Genetic Phenotypes Gene Expression
human
OMIM:Gene, HGNC, GeneCards MASTL OMIM, MalaCards, KEGG Disease, DECIPHER Ensembl, Protein Atlas, Allen Brain Atlas
mouse
MGI, AGR Mastl MGI, IMPC Ensembl, Eurexpress, MGI, Allen Brain Atlas
zebrafish
ZFIN, AGR mastl ZFIN Ensembl
chicken
GEISHA MASTL Ensembl
fruit fly
worm
WORMBASE
Publications
First: Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. [Mol Cell 2006]
Most recent: The greatwall kinase is dominant over PKA in controlling the antagonistic function of ARPP19 in Xenopus oocytes. [Cell Cycle 2017]
View All Papers
Functional Ontologies tropicalis laevis.L laevis.S
GO 16 terms 16 terms 0 term
PANTHER mastl
KEGG Pathways K16309 K16309
KOG [T] cAMP-dependent protein kinase catalytic subunit (PKA)
Reagents tropicalis laevis.L laevis.S
CRISPR / TALEN CRISPR tools CRISPR tools CRISPR tools
Clones
GE Dharmacon GE Dharmacon GE Dharmacon
Source BioScience Source BioScience
Antibody Mastl Ab1 , Mastl Ab2 Mastl Ab1 , Mastl Ab2
ORF mastl.L ORF1
Affymetrix 1.0 Str.3977.1.S1_at Xl.3201.1.A1_at
Affymetrix 2.0 Xl2.3201.1.S1_at

Symbol legend[+]
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.2
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556