Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (285) GO Terms (22) Nucleotides (160) Proteins (221) Interactants (220) Wiki
XB-GENEPAGE-964547
Gene Symbol:
mastl

Gene Name:
microtubule associated serine/threonine kinase like

Synonyms:
greatwall , gwl , mast-l , thc2 , gw ( Add synonyms , Nomenclature history )

Gene Function:
cAMP-dependent protein kinase catalytic subunit (PKA)

Protein Function :
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: d...[+]



Interactants:
Loading ...

Diseases: 


Disease Ontology:
thrombocytopenia

OMIM:
THROMBOCYTOPENIA 2; THC2

External Links:
 
Xenbase Gene ID XB-GENE-964548 XB-GENE-964551 XB-GENE-17339965
Gene Symbol mastl mastl.L mastl.S
Chromosome Chr6 chr6L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2
CDS Gene model Gene model
Entrez Gene 100145700
414585
mRNA NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mastl mastl.L mastl.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards MASTL OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mastl MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mastl Ensembl
zebrafish
ZFIN, AGR mastl ZFIN Ensembl
chicken
GEISHA MASTL Ensembl
fruit fly
worm
Publications
First Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts., Mol Cell 2006  
Most Recent Bistable, Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation., Curr Biol 2020                                
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 20 terms 14 terms 0 term
PANTHER mastl
KEGG Pathways K16309 K16309
KOG [T] cAMP-dependent protein kinase catalytic subunit (PKA)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mastl
Antibodies Mastl Ab1 , Mastl Ab2 Mastl Ab1 , Mastl Ab2
ORFs mastl.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list